ID A0A158NY68_ATTCE Unreviewed; 1660 AA.
AC A0A158NY68;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN Name=105625766 {ECO:0000313|EnsemblMetazoa:XP_012062476.1};
OS Atta cephalotes (Leafcutter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=12957 {ECO:0000313|EnsemblMetazoa:XP_012062476.1, ECO:0000313|Proteomes:UP000005205};
RN [1] {ECO:0000313|Proteomes:UP000005205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21347285; DOI=10.1371/journal.pgen.1002007;
RA Suen G., Teiling C., Li L., Holt C., Abouheif E., Bornberg-Bauer E.,
RA Bouffard P., Caldera E.J., Cash E., Cavanaugh A., Denas O., Elhaik E.,
RA Fave M.J., Gadau J., Gibson J.D., Graur D., Grubbs K.J., Hagen D.E.,
RA Harkins T.T., Helmkampf M., Hu H., Johnson B.R., Kim J., Marsh S.E.,
RA Moeller J.A., Munoz-Torres M.C., Murphy M.C., Naughton M.C., Nigam S.,
RA Overson R., Rajakumar R., Reese J.T., Scott J.J., Smith C.R., Tao S.,
RA Tsutsui N.D., Viljakainen L., Wissler L., Yandell M.D., Zimmer F.,
RA Taylor J., Slater S.C., Clifton S.W., Warren W.C., Elsik C.G., Smith C.D.,
RA Weinstock G.M., Gerardo N.M., Currie C.R.;
RT "The genome sequence of the leaf-cutter ant Atta cephalotes reveals
RT insights into its obligate symbiotic lifestyle.";
RL PLoS Genet. 7:e1002007-e1002007(2011).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_012062476.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; ADTU01003247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADTU01003248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012062476.1; XM_012207086.1.
DR STRING; 12957.A0A158NY68; -.
DR EnsemblMetazoa; XM_012207086.1; XP_012062476.1; LOC105625766.
DR GeneID; 105625766; -.
DR KEGG; acep:105625766; -.
DR eggNOG; KOG1215; Eukaryota.
DR InParanoid; A0A158NY68; -.
DR OrthoDB; 2877710at2759; -.
DR Proteomes; UP000005205; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 11.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 11.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 11.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00192; LDLa; 12.
DR SMART; SM00135; LY; 8.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 11.
DR SUPFAM; SSF63825; YWTD domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 7.
DR PROSITE; PS50068; LDLRA_2; 11.
DR PROSITE; PS51120; LDLRB; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005205};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1368..1389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 221..260
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 390..433
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 434..476
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1002..1036
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 1220..1262
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 23..41
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 35..50
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 62..74
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 69..87
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 109..127
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 121..136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 156..174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 168..183
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 225..235
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 717..729
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 724..742
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 736..751
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 800..812
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 807..825
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 819..834
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 864..879
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 882..894
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 889..907
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 901..916
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 934..952
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1590..1608
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1660 AA; 187927 MW; 465BE66BFA447C12 CRC64;
MRLDSNFKTQ KCQNLHGKNS FICNNGQCIL LSYRCDGTDD CTDGSDEEDC DDYSDSNSSI
KCSKHEYKCK SNNCIPIAKF CDVIQDCPDG SDEYDDCVKD LNCSGRFQCA DEHCVFHDWV
CDSNKDCPDG SDEWNCNANK TSSASYCKIE NSQYLCENQL CIPLKLVCNG KDDCGDKSDE
AGCTSSCSVK CDHECKQTPK GSICFCKPGY KLQNDNRTCI DIDECQIYGV CDQECINTPG
SYSCRCQTDY FLQQDKKTCK AIAGEATIVF SAKTEIVGMY LDSQINFIVA KHLNRVIGVA
MNGDHTYWSD IEEDREVIVR STPQNKHEVI VMMGLKEISA IAVDWITQNI YFTDTGYNRI
GVCKDDGTYC TILINDTDKP TGLALLPTHG KMYWCDWSSN PHIAVAGMDG KNIRIFVSTN
LKAPQSLTID YPTNRLYWAD IKLKKIETIR LDGTDRRVVL HDIIEDPFSL AVFENKLYWS
DWESKSVESC NKFTGKDWNI LHLGQHSHFS VHIDHSAIKP KVDNPCHFNP CSELCMLNQE
NGYTCACTLD KKLNADNHTC QEVTKNLLIL HDTIFTNYYH GMLGKLKTRI ASKVLLPQDI
VSDPTSGQVI CYIMTERFEK AIVLFDPVSD TFKNTILHNV SYFSMAFDHV GNNLYMTNKP
SSSINVYNVK TLAMTVFYFK EYVPYYITLV PEERCDGNVH CPNGEDETIG CHXKKKCKKD
EFTCTNGECV SIKSHCNWHY DCTDQSDEEN CIKPKCTNDE FQCRNGVTPC ISKSLLCDGD
FDCEDGSDER PEACKSNASC LNDKFQCNDG NCISLSLKCN GIDDCLDGSD ERHCLAKSVY
LTNCTADKYR CLDTYLCLPK KVKCDGKSDC PKNDDEHNCV FCFDNEFTCD NAECIPENWV
CDQSDDCGDN SDEKNCDGSK KTIMESTKCD EFKCSIGTCL PYSKVCDGNR DCPDGSDENG
KCQIACMVNN FCKGLCYKTP KGDVCGCPYG YRLAADATSC EDINECENDV CSQFCRNTVG
SFECSCQEGY YLRNKVSCKA IGPAMEFITV TDNDIRKISS NLHSIDKIYS LSGLSINGLD
VNAVHDSIYW SNGEFGTIKK LNIKTKKVTT IMIVEHPQSL AVDWITDNVY VNDNGYLNTI
KVCNLEKEKC ATLIEIEEKA KVVSIVVDSI NRWLFWTQIT WQMDVPFSKI CRTDMMGADM
KIIGSDVSFV SGIAIDHIKS KLYWSDSFSK TIESSNFDGS QRSMFLRTNM YYPFGISIYE
QSLYWLMDTS GQLQSCKLYG KKSCETINIG KNNVHKQFAI LHISRQPVDK NPCNEKYCDY
MCVLKKDNAT CICLDGKSIE SNNICTNMNN GRTSFKNLTR NARYTSGLYS LIIIVLLIIV
LSLCIYYYYQ KNRLKSKSMN NLSCSSIHFH NPSYDRSNEV EVTLNSIVAG LSPGQHEYVN
PIDNKFLNLK DAMENSENRQ KSDPYSKERD IEEIEKQDSL IYFSKLRMLN QENGYTCACT
LDKELNRQSH LSSRDEMYCL VTPDSLVNCS KHEYQYLSTN LCLSKQVRMK CIPKSWECEK
HDCDDNSDKK SCVDSKKTIM ESTECDGFKC SIGTYLPYLK VCDGIQDCPD DSDENATPRG
DVYYPDGYHL AADATSCEDE RRINECEKDD EFARNFVEIQ
//
