ID A0A158P0I0_ATTCE Unreviewed; 3408 AA.
AC A0A158P0I0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Histone-lysine N-methyltransferase trithorax {ECO:0008006|Google:ProtNLM};
GN Name=105626604 {ECO:0000313|EnsemblMetazoa:XP_012063288.1};
OS Atta cephalotes (Leafcutter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=12957 {ECO:0000313|EnsemblMetazoa:XP_012063288.1, ECO:0000313|Proteomes:UP000005205};
RN [1] {ECO:0000313|Proteomes:UP000005205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21347285; DOI=10.1371/journal.pgen.1002007;
RA Suen G., Teiling C., Li L., Holt C., Abouheif E., Bornberg-Bauer E.,
RA Bouffard P., Caldera E.J., Cash E., Cavanaugh A., Denas O., Elhaik E.,
RA Fave M.J., Gadau J., Gibson J.D., Graur D., Grubbs K.J., Hagen D.E.,
RA Harkins T.T., Helmkampf M., Hu H., Johnson B.R., Kim J., Marsh S.E.,
RA Moeller J.A., Munoz-Torres M.C., Murphy M.C., Naughton M.C., Nigam S.,
RA Overson R., Rajakumar R., Reese J.T., Scott J.J., Smith C.R., Tao S.,
RA Tsutsui N.D., Viljakainen L., Wissler L., Yandell M.D., Zimmer F.,
RA Taylor J., Slater S.C., Clifton S.W., Warren W.C., Elsik C.G., Smith C.D.,
RA Weinstock G.M., Gerardo N.M., Currie C.R.;
RT "The genome sequence of the leaf-cutter ant Atta cephalotes reveals
RT insights into its obligate symbiotic lifestyle.";
RL PLoS Genet. 7:e1002007-e1002007(2011).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_012063288.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; ADTU01005041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012063288.1; XM_012207898.1.
DR STRING; 12957.A0A158P0I0; -.
DR EnsemblMetazoa; XM_012207898.1; XP_012063288.1; LOC105626604.
DR GeneID; 105626604; -.
DR KEGG; acep:105626604; -.
DR eggNOG; KOG1084; Eukaryota.
DR InParanoid; A0A158P0I0; -.
DR OrthoDB; 5490909at2759; -.
DR Proteomes; UP000005205; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd15506; PHD1_KMT2A_like; 1.
DR CDD; cd15508; PHD3_KMT2A_like; 1.
DR CDD; cd15489; PHD_SF; 1.
DR CDD; cd19170; SET_KMT2A_2B; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR047219; KMT2A_2B_SET.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45838:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE TRITHORAX; 1.
DR PANTHER; PTHR45838; HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00249; PHD; 4.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005205};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 537..650
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 904..954
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 951..1003
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1031..1092
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1384..1492
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 3270..3386
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 3392..3408
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 332..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1153..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1899..1964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2231..2301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2969..2996
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 349..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1904..1950
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2231..2297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3408 AA; 378260 MW; B12994A15E7B12F4 CRC64;
MGRSKFPGKP PKTATRKRIK VLGQPEAAQN DPVTVAENIY YGLSLFNETF GDNEKEHPPF
HGFSTKEANL SASYIKTQQH DAEKTSDKLP SVTVENLAPR SSTKKDVIDI KNSPTDIENS
TEKFTNSNPK PVKDITRLQS VTNPNTKHSK IHRAKSRKNC KNIKFSNYLK NPVLKSVNNI
LDQHQRTRQL RNSTAKRLLQ RAKSGSNTRN LVVQSGEKPS TVRKFVLPVR SVHSSRVIKP
NKRFIEELEE ISTTEYSENE IGVHVKKTKL NPDKLSNLES KLKGNTVNKL CTKFKEARSK
PKRVIQSVNS NAEIITQSVK NIEKSANSVQ NAQISKSAHR EVKKSHTVSC KNKISNSTSD
NYNSNQECSQ NSSRTTQTVK STISRNQKQI SIPTKVLPDS NVPHFESSRV QTRSGTQNEI
ASDLSNNQVS FNSGAGLTEG GCAEIENQLG HGNKTAVNTL NNFETENNLS ENESEHSNQE
GESPDFSGMK LNGGKVILRK ARLKLDNKCL AGTEGPFSTT STSNTMGGST NLGLTGTIKC
GVCGAVRFYR FVKQARKFGI HSCESCRKFI SKMIKRQACA KSSNNVLPIL QCHKGDGLCL
VPPVVRSQQW NLMRCVYKAR CPACWLKMCL KCYNIPPPLR TGLNALLPPL MRDPLSISLP
LGQDEDGQGQ KLCSSKLSWP AEDSSERNLF KSAMSWRNFE MGHKTSYQGT GGFLYTKIDK
FDSSMSISPN KKRRKNNRIK VRKKIKNPVV ASSSASQQSQ PLRQRLELKG PRVKHVCRSA
SVALGQPIAT FPTVDAKEDN EHGKNIPKTV KENERIEKRD DVKEKEIQKH NEDNNLNLNV
NTTQQSHSRR GKPQQNVSTL HFPVSKAVMD TVYTVSIDFW EQYDPSEVGA KGFALIGSEL
FHIPAICYLC GSAGKEPLIH CQCCCEPYHA FCLEPSEWNA CAQPNWCCPR CTICQSCHLR
SGPKLSCIRC RQSFHHSCLS KSGVSSRLYS PDRPYVCQSC IKCKSCGSEG VNVHVGNLPL
CSMCFKLRQQ GNYCPLCQRC YNENDFDTKM MECSECSCWV HARCEGLSDE RYQILSYLPD
SIEFTCSQCS SNSSSSIWRN AIEAELKAGF IGVIKSLSKN RKICTALKWS PRKECLCRPV
LSVRKLEFPE EDKNETNCTK ENEESEECNG DKSIDIDSSS SANYRDGMNK PDLEEHSIDN
PIRKGLRRLR QKFHLKECSV RVKNCVPKDS QDNEKKDLIN QDSLVSSTST DGTECHCSEQ
QIIARPSPTL MSVKRKVNSN EYKSLLQFHC DMMHVINRVG SKDLIETYHE ILQEVFPWFI
PKNFKSSDNN DDTLMPTKDV GEDIALTTKF DDPILEAWKE EVMKAPKAIA AKTANLYNIH
VEDSRSCCLC KGLGDGHETK EGRLLYCGQN EWVHANCALW SNEVFEEIDG SLQNVHSAIS
RGRLIRCSEC GKKGASIGCC AKNCSNTFHF PCARNVGLAF NDDKTVFCIS HSNTSHVYKS
LQNENEFSLK RPVYVELDRK KKKFAEPNKV KLMIGSLMVD CLGTVIPEFS DTAEKIIPCD
YKCSRLYWST VNPYKIVRYY IRTYVQVYMP DVSSDMENNI TIDHSKEQEK DEVPTDYLAV
KQTLDALIDF VCNKEVDENL AEQNNTDLLP PELKEAIFED LPHDLLDGIS MQDIFPKMSY
EDFLAMDLKN DGSFSTDLFK DDMLSSEVEE TIKPSESKIS KIDSSLLELG AHNDLWVRLE
AKTAMQDLMD DLFNSKSQKR GGRELKRSKS EVMSNNPLIV GGQRHHQRSC SLTWSCKLDN
TYGSNIKRRK LPRNPSSTKS SETGLIVLDA QNERTSMFHE LRIPESIMVT VGRGNTPNIL
SDSVRELKYC IEDSAGLNRR VLPARDDVKE HKRLLWHPRQ QQPRIVQVDG SVDANSASEC
SSPEYNAEEK NANLQTSESL SIPQLDGIND EHSSDASESS SEMELGLYAR PSNLLHSKRI
FGFIRSHVSS NCDKKTKSGN SNFITAPTIR CTSHKAEVLF KEKNLKMNLQ IPQVDGAGDI
SSDDECVSSQ HMMTHERLLH TSYESSPFED IDVTCKRCGL TYRNEESYNR HLNNCDTMIT
SDSDSETMDN KLASPESGFS PNMGSMSSQF ITLSPSEGHT LTTDYSDIQA TSPIEASVAS
PHPSIQIEPI AQAIITPQIH ATHATVETVH QTVLTSNDVI VQTQYTRRTT TLPNPAVLPP
QESTVQITEI TDPPSISSDS NATAHGIVNT PMSSPDSTSS QTVPSPEMSP SFSSMGVQTA
HESMQTNAQI TRTSSKKNLR VAKPKTKNIK PQQHVLKNVI QSPQNIAHNV KFQPTTMSNG
PPVIQLHQTT PRPPTVILQQ VASPGIVSAY VEALQQQSGQ NLQYITTIGD GQHETGFKPQ
LIAANSLVPG TYIQAPSTDN LLLQNGGISI LPSVQIAQTQ PTVLGTIIQQ QPNAIQCGVI
SSEQLLLSST PTLEMFADPT GGMFVSNQPM YYGLETIVSN TVMSSSQFMT GTVPQVLASS
YQTTTQVFQA SKLMEPIVDV QAMSGVPTVT TMQNVSSMPN ISGMPNITGV SNIASMQNVS
GMSNMSGVPY VVVNQSAPSL PPAAAPVPSP APTLASAPMP ASASIPAPMS IPTPVSIPTP
VSIPTPVSLP TPMSIPTPVS IPTPVSIPTS VSMPAPISIS ASTLAVEPIV TPPQINISAT
SPERAYGGIA CNVVTPVPCQ NATIEHPMAS IQVADVCSSN ATSISVMTPT KLSSSALPTI
PRVAVRPSPV THLVQANHGA WKITEPLFGA EQPMNNSVRP YFDSKHVSEN TSMIKSSISS
SKIPPLSNHY VTQRNLVLNH KSNHDVNSIH KSYSNGIALN PNSMNTCINN NNPIIVSNSN
SVQNKITMPT NNMPTSRPMN RVLPMQAVTL KQDPAKKDDL AIEEPTKPVI KPAEPEIVES
KKEIIEQIVQ IKKPETALSN ISDNIKLNTE TIEKVKENLK LELDKEKLQN TSLKIVLQKQ
LQDGSYKITR NMKAVTQSKK TPQVTSVEIL PSKQVPQIAS LQLLPIKTFT LKANKFEDKV
KPMDAKVNIL KAKAPPVAVK KPRIVTKSIR PLRNNPQQNP PQMHNCSKGP ILMYEIKSQD
GFTHTASSMT EVWETVYQAV QNARKVHNLS PLPHNPLSEG LGLENNAAIY LIEQLPGVNR
CSKYKPKFHT LEPPKPDEME NELPAACANG AARAEPFKGR KVHDMFSWLA SQHRPHPNII
TISETESRRA VSTNLPMAMR FRILKETSKA SVGVYYSHIH GRGLFCLRDI EPGEMVIEYA
GEVIRSSLTD KREKYYDSKN IGCYMFKIDD HLVVDATMKG NAARFINHSC EPNCYSRVVD
ILGKKHILIF ALRRIIQGEE LTYDYKFPFE DIKIPCTCGS RKCRKYLN
//
