ID   A0A158PEM4_ANGCS        Unreviewed;       887 AA.
AC   A0A158PEM4;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=SSD domain-containing protein {ECO:0000313|WBParaSite:ACOC_0000217401-mRNA-1};
GN   ORFNames=ACOC_LOCUS2175 {ECO:0000313|EMBL:VDM53760.1};
OS   Angiostrongylus costaricensis (Nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae;
OC   Angiostrongylus.
OX   NCBI_TaxID=334426 {ECO:0000313|Proteomes:UP000050601, ECO:0000313|WBParaSite:ACOC_0000217401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ACOC_0000217401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDM53760.1, ECO:0000313|Proteomes:UP000267027}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Costa Rica {ECO:0000313|EMBL:VDM53760.1,
RC   ECO:0000313|Proteomes:UP000267027};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; UYYA01000402; VDM53760.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A158PEM4; -.
DR   WBParaSite; ACOC_0000217401-mRNA-1; ACOC_0000217401-mRNA-1; ACOC_0000217401.
DR   OMA; VCAIFIP; -.
DR   Proteomes; UP000050601; Unplaced.
DR   Proteomes; UP000267027; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   PANTHER; PTHR10796:SF90; SSD DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000267027};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        39..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        305..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        338..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        408..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        473..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        688..708
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        714..735
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        742..763
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        797..818
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        825..849
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          273..434
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   887 AA;  100730 MW;  3CD64B52B29FA31E CRC64;
     MLTRVSENQS HRKLPRFSRN FSLHGLFYLL GKSVATYPYA YLLVGALICM NSGGMYWMNL
     RDRIRDGYTP VNAPSRYETD VMREFWNSTS DPMMTIVLLL ARDQGSMHRK PHLDEAERLV
     DFLYTNFTVD HKGTKLRFKN LCSPYCNMNE VFKTFKSAFD VQYSHAVNNE SLSTHIQLKY
     PVAKYFGISL HLERCFFGVR LKVFVENSTQ LYLSYIVVTI FASWEIAAYE WSVEYNSCSN
     ESDSLVEIQM RINVIGTEIL DMEMIRDTRK ITPFFAAGFA FMITFVSVCV FCSALYYNAL
     DAGKILVGVG ATFCPIIAIT CSYGIVSMLG CRVNSFMLVM PFLIMGIGVD DSFLMIHTWQ
     RMIRDGYNVK ERLGMVYEHV GPSITITSLT NFLSFGIGAY TPTPEIRLFC FATALAMALT
     FIFQLIVFGP ILAIATGFEK AGTVEEHSSW RNVLDASSNK LLHYYCCLLG HKVFISFVVA
     ATFVYWYFAI IGILEIKTRL DTVKILPKNS PLQRPNYILS NIVWAEYHAV TVVISTPFDV
     TNKTHTTLFW DMIHNFETLP HSKGSSSSLI WLRDYIDYYY NGDPANIISV FLRRDDINPY
     LANITLNKLN DFLESKVYRH WEAFMRIRNY NDAPIVERFW LTVAYENTSQ WETLLVANCS
     INQYPDLNAS VWEPNGMFVD QMLSLKSGAL QTSVLTLACM AVVCALFIPN PCSVITAGIS
     IASISLGVIG FLSIWKFDLD PVVMAALLMS IGMSVDFIAH VAYHYQLTVR KEFRDGRVVK
     IPVRGPQQKL EHTLRSVGWP MLQAAISTVC CTLPLLLLAS YSPSVFVTAI FLVVTWGALH
     GLVVLPSFLG CLPDYLTNGN CCRTFISPSS KRSCRYSEYS HESMRRM
//