ID A0A158PIY8_ANGCS Unreviewed; 952 AA.
AC A0A158PIY8;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Alpha-actinin, sarcomeric {ECO:0000313|WBParaSite:ACOC_0000811001-mRNA-1};
GN ORFNames=ACOC_LOCUS8111 {ECO:0000313|EMBL:VDM59696.1};
OS Angiostrongylus costaricensis (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae;
OC Angiostrongylus.
OX NCBI_TaxID=334426 {ECO:0000313|Proteomes:UP000050601, ECO:0000313|WBParaSite:ACOC_0000811001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ACOC_0000811001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM59696.1, ECO:0000313|Proteomes:UP000267027}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Costa Rica {ECO:0000313|EMBL:VDM59696.1,
RC ECO:0000313|Proteomes:UP000267027};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the alpha-actinin family.
CC {ECO:0000256|ARBA:ARBA00010255}.
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DR EMBL; UYYA01004116; VDM59696.1; -; Genomic_DNA.
DR STRING; 334426.A0A158PIY8; -.
DR WBParaSite; ACOC_0000811001-mRNA-1; ACOC_0000811001-mRNA-1; ACOC_0000811001.
DR OMA; CYEGVEV; -.
DR Proteomes; UP000050601; Unplaced.
DR Proteomes; UP000267027; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd21214; CH_ACTN_rpt1; 1.
DR CDD; cd21216; CH_ACTN_rpt2; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 1.10.418.10; Calponin-like domain; 3.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF442; ALPHA-ACTININ, SARCOMERIC-RELATED; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00435; Spectrin; 3.
DR SMART; SM00033; CH; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00150; SPEC; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000267027};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 42..146
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 155..259
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 810..844
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 850..885
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 952 AA; 111122 MW; 6DF60A10647431CF CRC64;
MVDYYNAPPA FHQQQQHMSG YDYTQQEEEW DREGLLDPAW EKQQKKTFTA WCNSHLRKAG
TSIDLIEEDF RNGLKLMLLL EVISGEPLPR PDRGKMRFHK IANVNKALEY IESKGVKLVS
IGAEEIVDGN VKMTLGLIWT IILRFAIQDI NVEELSARDG LLLWCQRKTA PYNNVNVQNF
HTSWKDGLAF CALIHRHRPE LLDYHQLHKG DPLHNLNLAF DIAEKHLDIP RMLDAEDTAN
NPDEKSIMTY VSCFYHAFRN APEIRAAPVP SRAIPIQPER DWRKDVIFSD MVNSHPDEKA
VMTYVSCYYH YFSGMRKAET AANRICRVLK VNQENEKMMQ EYEHLASDLL AWINHWMPWL
ANRTTDDNLA MAQKKLDDYR NYRRHEKPPR IEDKGRLETL FNTLQTRLRL SNRPAFLPRD
GHLVKDISNA WKNLEDSEKG FEEWLLSEIM RLERLEHLAE KFRRKCTLHE EWAHGKEEAL
RSQDWKSCGL YKIKALRKRH EAFESDLGAH QDRVEQIALI ARELNNLRYP DIVPINSRCQ
HICSQWDRLG QLAAQRRVTL EEAERVAERL DSLYLDFAKR AAPFNNWLDG AREDLADLVI
VHEMREIEEL CTAHDQFKST LGDADKEFAS ISGIEQEIER LVESHGLDRE LLRNPYTDLV
AADIRRKWGE VQQAVPRRDG QLQSELRRQQ NNERLRTVFA EKANQVGPWL ERELEQVLAI
GLGGRGRLED AVYQLRGIYQ DALTHKPNLD ELERIHQEMQ ENFVFENRKS RYSMESLRVG
WESLITSINR TMSELENQIL MRDSKGITEE QINEYRASFN HFDKDRQGLD PEQLRSCLIS
IGYNIRPGRE GDVDLHRILS HVDPNRMGRV PFDAFLDFMT LETADSDTVE QMIDSFRILA
AGKPFITADE LRRELPSDQA AYCMQRMAPY NDPHAPPGSF DYVTFSRSLY SQ
//
