ID   A0A158PN67_ANISI        Unreviewed;       585 AA.
AC   A0A158PN67;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Long-chain-fatty-acid--CoA ligase {ECO:0000256|ARBA:ARBA00041297};
GN   ORFNames=ASIM_LOCUS10716 {ECO:0000313|EMBL:VDK43506.1};
OS   Anisakis simplex (Herring worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC   Anisakis simplex complex.
OX   NCBI_TaxID=6269 {ECO:0000313|Proteomes:UP000036680, ECO:0000313|WBParaSite:ASIM_0001115801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ASIM_0001115801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDK43506.1, ECO:0000313|Proteomes:UP000267096}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate +
CC         tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:65052, ChEBI:CHEBI:456215;
CC         Evidence={ECO:0000256|ARBA:ARBA00036436};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640;
CC         Evidence={ECO:0000256|ARBA:ARBA00036436};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a very long-chain fatty acid + ATP + CoA = a very long-chain
CC         fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:54536,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:58950, ChEBI:CHEBI:138261, ChEBI:CHEBI:456215;
CC         Evidence={ECO:0000256|ARBA:ARBA00036527};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54537;
CC         Evidence={ECO:0000256|ARBA:ARBA00036527};
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; UYRR01031014; VDK43506.1; -; Genomic_DNA.
DR   WBParaSite; ASIM_0001115801-mRNA-1; ASIM_0001115801-mRNA-1; ASIM_0001115801.
DR   Proteomes; UP000036680; Unplaced.
DR   Proteomes; UP000267096; Unassembled WGS sequence.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43107:SF15; FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A; 1.
DR   PANTHER; PTHR43107; LONG-CHAIN FATTY ACID TRANSPORT PROTEIN; 1.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000267096}.
FT   DOMAIN          13..77
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          115..363
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          468..553
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   585 AA;  67064 MW;  A797277085A9EAFF CRC64;
     MIANRPMHEI FLENVRKCPN KEAYVEIGTH RRVTFMQFND LTNRYANFFK DEGYEFGDVI
     SLFMSNSIDY VAVWMGLTLE TVFGNGLMNQ CKIYVIDTTA ENHLNVFHIK DKILKQKADE
     PKSPSSLNFQ SILCYIYTSG TTGHPKPAII KHFSTFCHYV NEMSVIMQAC NEPKLRFYVM
     VMGCGKSFNI MSTDRIYVTM PMYHSSAGII GVGQALLNAS TCVIRKKFSA SNFWIDCINY
     ECTVSQYIGE MCRYLLAQKE IPEEKLHKVR LMYGNGLRIE IWRDFVTRFH IAKIGEFYGS
     TEGNSNIVNI DNRIGACGFF PVYAFLAPVY PVRLLKTDEK TGEILRNKNG LCIACRPGET
     GEMVGLIKNN DLLLRFEGYV NNEETNKKII RNAFRFGDAV FSSGDLIYWD EYGYLYFKDR
     RGDTFRYGTR LGQLPLGRFL ESIENQSERK IPRHHADKWK GENVSTTEVE GILQPIKELS
     NIIVYGVEIP TVIFCVTEQE GRAGMVAVVS KEGTSHDQLI DKISSRLKAN LPQYAIPVFL
     RFCDKLDMTG TFKLKKVNLQ RDGFNLERCC DDAIYLWNSS NAKYM
//