ID A0A158PQ26_BRUPA Unreviewed; 535 AA.
AC A0A158PQ26;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Mesencephalic astrocyte-derived neurotrophic factor homolog {ECO:0000256|ARBA:ARBA00014267};
DE AltName: Full=MANF/CDNF-like protein {ECO:0000256|ARBA:ARBA00032923};
GN ORFNames=BPAG_LOCUS830 {ECO:0000313|EMBL:VDN82016.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000082901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0000082901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN82016.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ARMET family.
CC {ECO:0000256|ARBA:ARBA00005617}.
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DR EMBL; UZAD01000046; VDN82016.1; -; Genomic_DNA.
DR STRING; 6280.A0A158PQ26; -.
DR WBParaSite; BPAG_0000082901-mRNA-1; BPAG_0000082901-mRNA-1; BPAG_0000082901.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd00195; UBCc; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR Gene3D; 1.10.225.10; Saposin-like; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR045333; ARMET-like.
DR InterPro; IPR019345; ARMET_C.
DR InterPro; IPR045332; ARMET_N.
DR InterPro; IPR040463; BAP29/BAP31_N.
DR InterPro; IPR041672; Bap31/Bap29_C.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR000608; UBQ-conjugat_E2.
DR InterPro; IPR023313; UBQ-conjugating_AS.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR12990; ARMET-LIKE PROTEIN; 1.
DR PANTHER; PTHR12990:SF5; MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR HOMOLOG; 1.
DR Pfam; PF10208; ARMET_C; 1.
DR Pfam; PF20145; ARMET_N; 1.
DR Pfam; PF05529; Bap31; 1.
DR Pfam; PF18035; Bap31_Bap29_C; 1.
DR Pfam; PF00179; UQ_con; 1.
DR SMART; SM00212; UBCc; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS00183; UBC_1; 1.
DR PROSITE; PS50127; UBC_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..535
FT /note="Mesencephalic astrocyte-derived neurotrophic factor
FT homolog"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041044406"
FT TRANSMEM 324..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 172..318
FT /note="UBC core"
FT /evidence="ECO:0000259|PROSITE:PS50127"
FT COILED 480..528
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 256
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10133"
SQ SEQUENCE 535 AA; 60966 MW; 5ACE44799BFF9451 CRC64;
MQKMWFANLL VPLFLPYFLY AKRQESCEVC EKVLRDVMNS MAVSDRSDAG RIDEALREHC
GGIKGKENKF CFYVGALPES ATSIMNDVVK PLSWSMPVEK VCEKLRTMDS QICELKFDKD
IDWETVDLKK LRVKELKKIL EDWGEECKGC TEKSEYIAKI VELKSKYIMA GALPRRIAKE
TQRLIADPVP GISAVPDDNN ARYFHVIIAG PEGSPFAGGV FKLELFLPEE YPMAAPKVRF
MTKIYHPNID KLGRICLDIL KDKWSPALQI RTVLLSIQAL LSAPNPDDPL ATDVAEQWKS
NESDAIRIAQ EWTRIHANGQ KMTLQWFVVA LILYLEIAVV LLLLLPWIRP TLWSKFFKSR
IVNTFEKHAT VYFISALCIL LLLFADAIRE VRKYANEVAI EGSIRHTADS ENVVHMRLFR
AQRNLYISGF ALLLFLIIKR LVALLSRGAL LEAAAEAAMK QAESATKMAK SYMYGEGERE
KELERQVEEL GRELKSAQVD RDTMKEQAES LEREYDRVCG LLKLAEKASG DKKED
//