ID A0A158PQE0_BRUPA Unreviewed; 1028 AA.
AC A0A158PQE0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 6 {ECO:0000256|ARBA:ARBA00020973, ECO:0000256|RuleBase:RU365075};
DE Short=COG complex subunit 6 {ECO:0000256|RuleBase:RU365075};
DE AltName: Full=Component of oligomeric Golgi complex 6 {ECO:0000256|ARBA:ARBA00031348, ECO:0000256|RuleBase:RU365075};
GN ORFNames=BPAG_LOCUS1621 {ECO:0000313|EMBL:VDN82807.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000164001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0000164001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN82807.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for normal Golgi function.
CC {ECO:0000256|ARBA:ARBA00003627, ECO:0000256|RuleBase:RU365075}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000256|ARBA:ARBA00011166}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395, ECO:0000256|RuleBase:RU365075};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395,
CC ECO:0000256|RuleBase:RU365075}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000256|ARBA:ARBA00011023,
CC ECO:0000256|RuleBase:RU365075}.
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DR EMBL; UZAD01000141; VDN82807.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158PQE0; -.
DR STRING; 6280.A0A158PQE0; -.
DR WBParaSite; BPAG_0000164001-mRNA-1; BPAG_0000164001-mRNA-1; BPAG_0000164001.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1540.10; Rhomboid-like; 1.
DR InterPro; IPR010490; COG6.
DR InterPro; IPR048369; COG6_C.
DR InterPro; IPR048368; COG6_N.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR PANTHER; PTHR21506; COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6; 1.
DR PANTHER; PTHR21506:SF0; CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6; 1.
DR Pfam; PF20653; COG6_C; 1.
DR Pfam; PF06419; COG6_N; 1.
DR Pfam; PF01694; Rhomboid; 1.
DR SMART; SM01087; COG6; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF144091; Rhomboid-like; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU365075};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365075};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365075};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365075}.
FT TRANSMEM 709..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 788..809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 821..839
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..157
FT /note="Conserved oligomeric complex COG6 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06419"
FT DOMAIN 194..634
FT /note="Conserved Oligomeric Golgi complex subunit 6 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF20653"
FT DOMAIN 745..894
FT /note="Peptidase S54 rhomboid"
FT /evidence="ECO:0000259|Pfam:PF01694"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1028 AA; 116773 MW; 3844EFA856FB729B CRC64;
MLTHGVNIKP TSSSDSSNPI RKKVESLVSQ KLHTDQDFLK MVDYVAPMVN KIDIHVERRL
MYELEERKIK ANREYLKAFG LVNDRVQDFV AKVMQLSSIC QDMTNKIQSN KAKTQDLLSR
TAALQNEKRT LERKQIAIDN FLSRYSLKPE EETALKGSDA DGTVNAKFFA ALQRVKQIHH
DSKQLLRSSG EHLAALEIME EMANKLEEAY EVLYRSIQRE CRLLNVEFLE LKGVLVQSIA
SLQDREVLFK YALDEYSTAR RNYVVRAYID ALTRGGAGGT PKPIEMLSHD PLRYISDMLA
WIHQAMATER ELLQALLKLC NSDVLKENSI SIQSQISEAL CRPFKVRVEQ ALTTETNCIV
LYRLSCLFTF YLETMSSSLN SDSMLIQTFT ELKELTLNLF FSGLHSLVQK LVGKIGTPDY
DLLPVSAVHQ VLVLLKDVLE SHDGGVAAVA DKKENFERIF TAVLDPLNQA VQLSATQLHS
PIDVAVFTLN CLSAINSAIM LYQFTDSRLE MIKAQIDANI DVLVSEQATF IITQTGLIEL
YRKASAHQPS QGALSEIAGM EPSQISSTLL SFDTFLTNPN KYKSDQCVKI SSARLRDTIR
ERTIETVVAA YRIIYNKVID PSNKYSQLPI KTVEEVEICG PRITEGMDVK YGTFQNLDSV
FGESRKFLDT FQFCSKLEMF FHQNRRRQNN YGIYLLAYQL FNSRYIPPVT LAVIIFQMAI
FLGYFPFLAQ HRAEAMCLLP SRILYRCEWL RMLASTIMHV DDMHLYFNMI SLLWKGRRLE
PWLGSNRFLL LLAVFAVATS STMVGLSYLA DEVFSFNGGG YMNQCAIGFS GVLFALKVLH
TTYFPYSDHN LFGWLPIPSQ LACWAELFFL QMLTPNVSFI GHLSGIIVGL AYTMGPLKTV
VDILESIISL LLGSIPKSFS QTRNRTRSNN RNWFTNLSFG GRNSAAYERP SYGWENEQSY
CCFNEILTSI QVVCLKRSSY GEQHREVCMK TVDICPSSKP FLLSIFTYYI LELLAELLLI
TSVNEITK
//
