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Database: UniProt
Entry: A0A158PQQ2_BRUPA
LinkDB: A0A158PQQ2_BRUPA
Original site: A0A158PQQ2_BRUPA 
ID   A0A158PQQ2_BRUPA        Unreviewed;      5139 AA.
AC   A0A158PQQ2;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   13-FEB-2019, entry version 14.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:VDN89344.1, ECO:0000313|WBParaSite:BPAG_0000819601-mRNA-1};
GN   ORFNames=BPAG_LOCUS8158 {ECO:0000313|EMBL:VDN89344.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|WBParaSite:BPAG_0000819601-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000819601-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:BPAG_0000819601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:VDN89344.1}
RP   NUCLEOTIDE SEQUENCE.
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAD01013131; VDN89344.1; -; Genomic_DNA.
DR   WBParaSite; BPAG_0000819601-mRNA-1; BPAG_0000819601-mRNA-1; BPAG_0000819601.
DR   Proteomes; UP000038020; Genome Assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000038020};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000038020};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4695   4712       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4753   4775       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4891   4913       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4933   4958       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5018   5037       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      104    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    209       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    273       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      368    426       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      605    826       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1049   1243       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1499   1710       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4252   4287       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4290   4322       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4265   4276       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4300   4311       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   5139 AA;  585399 MW;  1A77D7508D9059BC CRC64;
     MTDKEGTGDG EQDDISFLRT GDIVAMTCMA SASREGVLGS ERVCLCTEGF GNRMCSLQNV
     SDRDLPADIS MCMLYIDNAL SVRALQEMMS NDKELRGAGS AGGHKTLLYG HAVQLKHVQS
     EMYLACLSSC SSNDKLAFDV GVQENNEGEA CWWTIHPASK QRSEGEKVRV GDDVILVSVA
     TERYLHMTHS KGFMVIASFH QTLWNITSVS SGSVRIRNMG ALFGNDVLRF FHGNDEVLTI
     PENWSEHPQQ NMAIYEGGAA VSQARSLWRI ELIRIKWHGA LVGWEQPFRI RHITSGRYDF
     QLLKKIALKA YYSKREHHIL FRYLGVMENV IQLYDKDKAE FDTTAFVMYQ TKDLKKQLLE
     EKEEGMGIAT IRYGETNAFI QHIKTELWLS YQTSETTKKG LGKVEEKKAV ALKDGHMDDC
     FTFFMALEEE SKSARVIRKC SSVLNRFLRG IEALQREGKQ AQDWNRVDLS EVLKLMEDLI
     DYFAQPDEDD FEASQNRLRA LRSRQDLFQE EGVLNMILDT IDKFSQMEAV RDFAGLLNED
     TQMMWEEIST YLYLLVAAMI KGNHYNCAQF ASAQRLQWLF GRLSNPQSAE GILDVLYCVL
     TESPEALNMI NESHIKSVIS LLEKVGRDPK VLDVLSSLCE GNGMAVRSSQ NTITQYLLPG
     KDLLLQTKMR DHVSSMTPNI LVGVVEGSSQ FRRWYYEAEV EHIERMTKTE PYLRIGWANS
     MGYKPFPGSG DGWGCIGVGD DYYSYGFDGR CIYCATKKHV IWTRTLQKGD VVGCLLDLNI
     PEISFTVNGQ STAGLFKNFN IDGFFFPVMS LSAKVSCRFM FGGIEGRLRF GPPPGFSALI
     EAAANKLEIG ECVSFGDIAK NVYTGPSILR QNTEPFVPKL VDISAVVLPH FAMEIHEKMA
     ENLHELWAMR KIELGWSYGE VRDEKTRRHP CLTSFQQLPP NEKAYNINLA IDTMKTIEAL
     RYHMILDEPP VRLRPVRLPQ NYQQSNGFKP QPLDCHEIVL DDNMFSLIDA LAKNTHNVWA
     REKIRRGWTF GLNEKLLLLQ FVNISQKRSP HLVPYEVVDQ RIKEANRESA TEFIKTLQLF
     GIFLESPVLE HDEGAEKELK VTKAFSRTYR AEALYAVSSG KWYFEFEVLT SGFMKVGWMD
     ISAQSTVDIG TDDRSYGFDG YLARKWHQGA GTYGREWKIG DIVGAFLDLS DHTISFSLNG
     ELLLDPSGSE MAFDNVLVTD GFVPAMTFSA GQRAKLNFGQ DSNSLKYFTT CGLQEGYEPF
     CVNMYRQMPM WYAKRLPQFE DIGLNSTIEV SRIPATGNNP PCLKITQKEV SSAVKCSIDT
     GDMTAQEKTK MEYIRLSLPV KCNEKLQPTK DKESIMRSLH EIEKQLAEEA QPVPTIRHPA
     IPKEFGDDTK KSLGRSLLSA FKHSTEEDEN SARSKPISFD SDHHLTETST IRMSGSMLEL
     SSTGEQRDGK HKRGGLMARF HQRKKEGMSS ENKRTTGMLV DGHVVSVDTI SAENIPPSMP
     KDDQDMPQSG PGRSRRGLMG SDKWKKKNEK LLEQRRPSIA ALEQSVIIDG NVPSDDVRTM
     IELGDKIDEF YYAIRIFPGQ DPANVWVGWV TPKYHFYAER FITGEAIRRC KYQGTSENVN
     EGESLEYRNC YVVNAAELLQ SVPEPGNTKV SGLLIGCIID TSVGELSFLA SKQDTGFRFK
     LEPGAILYPA AFVAPTSAEV LQFELGRIKY TFPLSSAMFK SSHKSLLPFC PPRLTVEKLN
     PVHWARVPNE CLRTTALKLS DFRGWSVLCD DPVRIMSIYI PEKDTSYDIL EMIEHNDLLT
     FHRQTLNLYC KLAAHGNQKV AHILCSHVDE DQILYAVKSH YLSGPLRQGF HDFLIAVHLR
     TYVNARQSTT HEYVIPLKQN HEIKNVFHPE IEDRFPQILG PTISIRPVIV CSEVRSNFGM
     DTESKLLPPA FNFVALKAHV MSALSSATEH AVISCRDLIG GNCLNHFEPL FKLFNSLLVI
     GIFDDDDLKN VMKLIHPIAF DENYVPGLKQ KGLTEIELAE GVKIQLTIIL ENICNIQLRH
     RVESLVSFAA GFVNDLQQDQ FSRYMSIKQT NMTPAEAARR TKEFRCPPRE QMFRLMKCKA
     VPDDSIGIML DDETEYDQCP MNETLQQQLR EFCSLLVGRV GCVKSEERNK LSELVILEEA
     NSWVDQLAQL VIRVPPPFTG EDKSMNHNGT ESFRLMICTM LKSWATSSVI ESNELIRKMF
     SLLLRQYTGV AEMMKALSQT YVLHERNIED VQDFIENLVQ VRELLSVQFE SAEEAILKRG
     LWKLMNNRIF FQHPDLMRLL TVHENVMSIM MNVLTAQQGA TNHGEHTEHV ENMEEIVNAQ
     DSKDASEMVV ACSRFLCYFC RTSRQNQKAM FEHLSFLLDN ATMLLARPSL RGSVPLDIAY
     SSFMDNNELA LALKEEELDK VTVYLSRCGL QPNLELVAKG YPDIGWDPVE GERYIDFLRF
     CVWINGESVE ENANLVIRLL IRRPECLGVA LKGEGQGLFS AFKEAIALSE DIRTLEENKN
     RAVIHSALLR EQPHYPNKET EGEDYVDLGA ATLDFYSSLV DLLAKCAPDK INIQAGKGDC
     MRARAILRSL ISLDDLGQIL ALRFTIPNLI TSVAADDVGP LPGLLPNHKQ SVLLFLDRVY
     GIDSQEMLFH FLEKSFLPDL RAATMMDSPC SVESDTALAL NRYLCNAVLP LLTSHSYYFA
     DAEHHAALLD TTLHTVYSMN HLRSLTKNQR DAVSDFLVAI TRELPPPMMV KLMRKVIIDI
     QEMDENLLVP LRILTLHYER CTKYYGSGNI YGMASETEKR LSMLLFYAIF DSLGSKQYDP
     ELFGKALPCL TAIGSAISPD YTLTTTGDDT DKIQKTKDRG IWNPDPVDVS EVQFDDDLKS
     VVAKFAEHFH DSWASRKIEK GWNYGELYSR QALTHPRLKP FVFLPDFEKN FYQERCAECL
     RALLVWNYSI ELTDHDAADK AVQNNTSLGS SIENFNPKPV DLSNMTLEKD MTGIAEKMAE
     ESHKIWAKKV LADLNRGGTM PPQLVPWDLL TDFERRKDRF RAAEILKFLQ YHGYRVWSSN
     KPEPSAERVK IDSERSSVEK RFAYNLLKKL IQYLEQASLK MKTIKPSQEL TRQNSFRKEG
     QDVKFFEKVV LPLMHAYFNA HKNYFLANSS VVQTGMASDK EKEMVANLFC RLASLLRFKN
     HAFGNVAKIT VRCLQGLIQS LDLRTLVKIN SDIVRTGLLT FFNNCADDLF SAVEELQNGG
     QYSLLRGQNL KSWVSLEFAN QMIIPVLTTM FVHLAINHFG SDLLLDEIQA ACYKILDSAY
     LLNSLAASTS QRKSIAYEMD KHRPALGQCL AAFAGCFPVA FLEDKFNKNN KYSLLAKSQD
     QSVQVQEMLQ NLLAHIPQLD KLLTEVEQVG QSGAMYREQP AAYDVDLPLI CSYLTYWWQL
     GPDSSNRSTV PVTDVGNEHI NRIFRALLQM IHNHIGVENA SWLCRINFFS VQIIPYVSCD
     AVKDYMLPVA ERLRRLAEKA YREEEHMRTH PDDADEGTVA EDNAHLVRDV YAYFPILMKY
     TDLHRAQWLK SPSWETDGVY ENVAIIFKIW SLSQHFKREE LNFMAQYEDE SVAGGTGEMK
     TGKAAIAERK KKRREGQMRK DKHAGSIVIA CLKRLLPVGL NVFGGRELDI VQQAKEKFLA
     KEPEDKIREL VRSLLDIPAK TDPTDKNAWQ LNLYRKIGKS QMRNKDVMTL DGIVDKITSM
     GQVVAILHVV GYFRFIYELT GHTEHPQGSM VNAWKTMLSS QRKRAVVACF RMIPLYGIPS
     KFKKESRWER VLTLQRKRMA ISLITASHLY RVEIHRAINF FLPAFNKLWL EDEDVGQDAL
     IKELTLEDEK QEQAYSKSGD EDVLSDEKDE KPQALPDPLK QLIQCFQRAA TSEQSQTISI
     ANDSLFVNFA QVMSKSIHIE DEDEGDDEGE LDQAQKEEIS QALRAEQAVL ADRGAAIMCL
     MYLSASNGEP SDMVAEALQL GIHLLNGGNS KIQEQYYSLE SLQMLIDYLQ LKKDVRFFTS
     LAGLMNKCSV LNLEMYERQI KAEGLGMGAE LAAAANQNLN DSEFTCSLFR FLQLTCEGHN
     LEFQNYLRAQ PGHTTSVNLI NCTVDYLLRL QESVMDFYWH YSSKDVIDES GKEYFLRAIH
     VCSQVFNTLT ESIQGPCTGN QMTLANSRLW DAINGFFFLF AHMMEKLYKN STQLELLREF
     LNLQKDMIVL MLSMLEGNVL NGSIGKQMVD ALVESEQNVE MILKFSDMFL KLKDLTTSQA
     FQDFDTNRDG WISPKEFQRA MESQKMYSVE EITYLMMCTD VNNDGKVDYM EFTERFHNPA
     RDIGFNVAVL LTNLKEHITN DPRLEKIIKQ ASSLLEYFDP YLGRIEIMGS SKKVEKIYFE
     IQESWLEQWS KQQIRDSKNS FLFNVLQDDG GDQGKLEAFI NFCEDTIFEM QHAAEISAGD
     IADSKIERAK KQRDYFLQQT SAGAQISATF KTGFTYGVNA ANALKPANVK KIFNTANATL
     RSMTWAQLIF AIITLSTKVS VKVTMFIYLV ICTLLRFGYY LMIPDRDELE VEQPALTMLE
     SAGIHHTSPV WPSLQQYRRS CNYDVFGVRL PPTDAQASTT LQAQSKTEAT IAPTSVQQSK
     TVLKPSVVAQ QCPSLYEAQS FSGTDVHYNQ ALSPTVSEYG INDYYEPKIA EQIPPRSRGS
     LLNMLARNFK TIEKTTLYLA FFINVILLFH RIRISDNVTS VNDTDDDMES VYISGVILPY
     TSYEVTGWML AQLLYWISVL HAVASFALLV SFYQLKIPLI TFKREKEVAR RLMFDGCWLT
     EDDDEERSLT NTVFWYIDRI VISSKSFPMK YWDKFVRRKT RQKFRDQTDE ETLVTVLGED
     KSATDTSFDY RYACWLWLGV ILTNGQFLYR VHYLLCSALG VFVSPFFYAF HLIDVVLSFP
     MLKAILQSVT HNLQQLILTI MMTLVVVYLY TVLAFNFFRK FYVQEGEGEE PPDRKCHNML
     TCFIYHFYAG VRAGGGIGDE LESPYGDDLE YWRMLYDISF FFFVIIILLA IMQGLIIDAF
     GELRDQQESA TEKLESSCFI CDIGKETFDR LPRGFEIHTS KEHNFANYLF FLQHLVNKDE
     TEYTGQETYV REKYDNRDWE FFPVGECFMK QYEDQLLQS
//
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