ID   A0A158PQT4_BRUPA        Unreviewed;       844 AA.
AC   A0A158PQT4;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Discoidin domain-containing receptor 2 {ECO:0000313|WBParaSite:BPAG_0000833901-mRNA-1};
GN   ORFNames=BPAG_LOCUS8301 {ECO:0000313|EMBL:VDN89487.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000833901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0000833901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN89487.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   EMBL; UZAD01013133; VDN89487.1; -; Genomic_DNA.
DR   WBParaSite; BPAG_0000833901-mRNA-1; BPAG_0000833901-mRNA-1; BPAG_0000833901.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   CDD; cd00057; FA58C; 1.
DR   Gene3D; 2.60.120.1190; -; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR048525; DDR1-2_DS-like.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR   PANTHER; PTHR24418:SF372; TYROSINE-PROTEIN KINASE SHARK; 1.
DR   Pfam; PF21114; DDR1-2_DS-like; 1.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00231; FA58C; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS01285; FA58C_1; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        381..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        415..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          13..170
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000259|PROSITE:PS50022"
FT   DOMAIN          591..834
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   844 AA;  96056 MW;  72293ABAAB9638D6 CRC64;
     MLNVVYVLAE AECQIIALGM ENGDIEDSQL SASTSFDMIS VGPQNARCEL IELASGAWCP
     KPLIKEGSYE FLEVNFEQIY VITGIETQGR YGNGTGREYT THYTIEYLRL NSSWIKYHNE
     ELIEIFNGND DTSTAVRQNF NPPIIASKIR IIPYSNYART MCLRVEFYGC IYNDGLMFYS
     MNNDGSRIDN YDFRDKTFEK SNMFSHFTNN KKGLGILTDG IIATTNPLDD NTDSDKITPT
     RWIGWNQLIT SKNYRRLLCA VFFDVRNLDG TVEIVFEFSG IRKFTQLEIW TYGISLRTTE
     IFFSHNGKKF SLASQMSSIQ RRPLDAVRNL PIRIPLHNAT GQAVKMKLSY KEQWLFLSEI
     YFTSSIVRKA IESTRITTTT IIATTTTTAT AIIISSVFGM FNITSPTAIE ESTGIIPIIY
     FIGLVILFLL ITCVLCAILI SRRHEPNPKN YNSGRAKVMV TSLGEKGFCT NFCDANDIDY
     HQIQNNGFCA DEKKLATVNK RNKKSPSWSD FHFPPPPSDI YGINESTTME PLLLPKIPVS
     PVVPIVRNIR DDHMKSKKIN ADDSLHYATA AVRIPDFKVK RRIEKFHMDQ IVLGCELGRG
     RFTVIRSCFI NGNNYAAKII TDRNKQTINV FNDEVKILSE INHENLIKLY GIDDNSTMYL
     ELALYGNVRQ YLAHKPEISF LNKLQLVMEI AAGMKYLEQK QIVHGHLSPQ CILIDQNKMI
     KIASPRGHLH HAQLRYSAPE CVIANEWSNK SDVWSFAVAA WEIFNDCTMI PFAKLTNAQL
     LENAKHIFNG HNAIYLELPT HLPQQVSNLI GECWQRISND RPTFLEIQYV LSMIQSGLSI
     SKKM
//