ID   A0A158PR84_BRUPA        Unreviewed;       441 AA.
AC   A0A158PR84;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=IRS-type PTB domain-containing protein {ECO:0000313|WBParaSite:BPAG_0000960001-mRNA-1};
GN   ORFNames=BPAG_LOCUS9562 {ECO:0000313|EMBL:VDN90748.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000960001-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0000960001-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN90748.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAD01013159; VDN90748.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A158PR84; -.
DR   STRING; 6280.A0A158PR84; -.
DR   WBParaSite; BPAG_0000960001-mRNA-1; BPAG_0000960001-mRNA-1; BPAG_0000960001.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd01202; PTB_FRS2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR038742; FRS2_PTB.
DR   InterPro; IPR002404; IRS_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR   PANTHER; PTHR21258:SF56; INSULIN RECEPTOR SUBSTRATE 1; 1.
DR   Pfam; PF02174; IRS; 1.
DR   SMART; SM01244; IRS; 1.
DR   SMART; SM00310; PTBI; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51064; IRS_PTB; 1.
PE   4: Predicted;
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00022707};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Myristate {ECO:0000256|ARBA:ARBA00022707};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627}.
FT   DOMAIN          26..134
FT                   /note="IRS-type PTB"
FT                   /evidence="ECO:0000259|PROSITE:PS51064"
SQ   SEQUENCE   441 AA;  49187 MW;  4AC197D955A6230B CRC64;
     MGNCMSQTGQ REFLKNFQNV ANRGGEARVG GAFMNDDPEA FQVFVKKRNK FIPGTLKVTE
     NEIVFIRSRC ETLNWPLHFL RRYGFTSAGI FFFESGRRCS SGEGLHTFQS HQAEAIFQLV
     QSRIQDNANM GIAIREARAQ SVTGSYHSVH NIPSSYTGTR IQPIQRYSSE GTANVGDCSP
     SAFGVTNYHR PLNRFNHRQL LFQIPKRPRS IAGPAHTAVW PLPPPSYHSP RSCFNRPAFM
     GNIVSEHVLQ RQPSEVSTCD HSYVNVLPQR RSATSSPQCV SPVLREFASS SHFTFGSTEQ
     NLGMTDFGSQ RFNTPVTFNT PVTGLSHRYP PCGFMCSYDR PSLNSYVNAR QDSGVSDRET
     TPPQLDYALV AVGITEEGSP STLRANQSNT RNDLASVGLT TNVNYTKIDL EKTRAIEVAA
     STVEKENPRR RHFTTNGQLD N
//