ID   A0A158PS08_BRUPA        Unreviewed;      1102 AA.
AC   A0A158PS08;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Host cell factor 1 {ECO:0000313|WBParaSite:BPAG_0001178301-mRNA-1};
GN   ORFNames=BPAG_LOCUS11745 {ECO:0000313|EMBL:VDN92931.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001178301-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0001178301-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN92931.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; UZAD01013246; VDN92931.1; -; Genomic_DNA.
DR   STRING; 6280.A0A158PS08; -.
DR   WBParaSite; BPAG_0001178301-mRNA-1; BPAG_0001178301-mRNA-1; BPAG_0001178301.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 6.10.250.2590; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR043536; HCF1/2.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   PANTHER; PTHR46003; HOST CELL FACTOR; 1.
DR   PANTHER; PTHR46003:SF1; HOST CELL FACTOR; 1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   Pfam; PF13415; Kelch_3; 2.
DR   Pfam; PF13854; Kelch_5; 1.
DR   SMART; SM00060; FN3; 2.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF117281; Kelch motif; 1.
PE   4: Predicted;
KW   Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          363..942
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|SMART:SM00060"
FT   DOMAIN          958..1053
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|SMART:SM00060"
FT   REGION          679..713
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          748..775
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          780..799
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        761..775
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1102 AA;  119647 MW;  26C7A39E927F05DB CRC64;
     MNAAKRGRLG NALPTLKWKK VVNTTGPTPR PRHGHRAVSI KDLMIVFGGG NEGIVDELHV
     YNTATNQWFV PAVKGEVPAG CAAYGIVCDG TKIYLFGGMV EYGRYSADLY ELQASKWEWK
     RLRPWPPKTG QPAPCARLGH SFTLASNQVC YIFGGLANAS DDPKNNVPRY LNDLYVLDLN
     KANNLQWEFP DTYGSPPPPR ESHSAVIVEN NGEHRRMIIF GGMNGCRLGD LWFLDLISMT
     WTKPEIGGIP PLPRSLHSAN IIAERMIVFG GWVPLLTPDT KLQQVEKEWK CTNTLASLNL
     HTMCWEDLSL ELLESAVPRA RAGHSAVVIN KRLYIWSGRD GYRKAWNNQV CCKDMWYLET
     DKPDAPGRVQ LIRATVSGLE VCWNAVPTAE AYFLQLRKFE TKPDDIIKSA SSLRVAATGK
     PLAGKVIAIR SGTASGPQVM KVVRSAPRGA AAIMGHGPRG HFLRVLPTPR LTTSNQAAVV
     KHPAAKAILV TKAPGAGCTA PHKLLFLQQA NCPTVSASNV STGDSPRLEV VESVSPHVVQ
     SGNSSAEPAA IATEHTPSIS TQGTTYTTPV MPNVDVGLPQ NLLDETAPDS ETCIIQNADA
     SEQHVKQSSD TATGAYRSSG FITQDTKKTN MSPLGTAHMQ TVTKVQCTQS GDAVASSKII
     RPKTSIIAIA PAHTQLKMLS SDVTPRKSPV EKDVKNKNEA NSASSADSNK PNKTGIAAVI
     ECKEEETDSR DKDNVEVDVI KEMKVEDISE DKETKNDVPL DKMEQSSNLD SSRDNKELQI
     VNTSSEEHSP DIKESEPLKS MSIETSNLVD SPSVSQSITA TSGIGTEIFA DVGITVNTDD
     GAVEVPNAAA MKECPSFTVL KVESGTTQSS RSHRTSPELK AESEWYNVGI IKGTSHLVTH
     YFLPCSAGME DAFGASYLRK AELEAGTAYH FRVAGINACG RGNWSEVTAF KNSLPGYPGA
     PSNIKVTKSS EGAHLTWDPP QSSIGKVTEY SVYLAVRNTH GRETHLSFVR VYVGSDPFCV
     VSLANLHTAH IDKSSKPAIL FRIAARNEKV GYGPATQVRW LQERPLRPVT VIGASAGSHR
     NPQQRTAPAQ TIQVPYKKLR FG
//