ID   A0A158PS71_BRUPA        Unreviewed;       847 AA.
AC   A0A158PS71;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=BPAG_LOCUS12276 {ECO:0000313|EMBL:VDN93462.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001231401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0001231401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN93462.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; UZAD01013279; VDN93462.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A158PS71; -.
DR   STRING; 6280.A0A158PS71; -.
DR   WBParaSite; BPAG_0001231401-mRNA-1; BPAG_0001231401-mRNA-1; BPAG_0001231401.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF58; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 3; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        424..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        468..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        585..604
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        616..637
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        672..691
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        723..744
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        779..805
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          94..125
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   847 AA;  97871 MW;  82C61C2418815F44 CRC64;
     MGSLYRSELM SLCQLFLHSE MAYDEIAKLG ELGVVHFIDL NSEMSSFQRR FVGDLKRCDL
     MAQKLKFIEE QILADSIPIP RLNEFVPAPR PSEMNTLETE IGEIEEQLLE NNKNMKNLMD
     NYAQLNECMQ CINKVQQLLT DGQRQQARQS LLGMENPTSG IGAIRRKLTN VMIGRKDSII
     PDRMSSIFSG ENFVAGIVER CHSTALERLL WRTCGLNVFV RTVTIDFSED PLLNDIPPKD
     VFMVFFSGAV LGLRVRKICK CYQAKIYDYK DPANNRVLHV PSLFGRVAEI KSIIEETRKY
     RNTLLRAAAF KAHEWDTKLQ KMSAIFVVMN MCNVDITQRY LIAECWIPTA DIIRVRKNFE
     KTGMLAQEKN GYVFLCQIET NKVPPTYFRV NKFTKIFQSI VNSYSIATYR EINPAPWTMI
     TFPFLFAVMF GDAGHGLIMF FVALAFILFE NKIKIDDEIM GSFYRGRYII LLMGLFSIYT
     GFIYNDFYSR SMNLFGSSWH NPYKSNLLEL TPVDMQFDLI LPPQYAYDRD KGPYVFGLDP
     VWNLAENRLT FTNSMKMKAS IVFGIIQMTY FRSTIDIYFT FIPQILFLSC VLIYLCIQIT
     VKWLMFSSIP GNVFGFFYPG SHCAPSLLIG LINMCMLKPR KEGFWNRSSS SEFEQCYLHE
     WYPNQGMVEK GLLMLTVLCI PVMLLVKPIY LKFKPQKIGH DEVANTDTYA VKFDFMDVMM
     YQGIHTIEFV LGCISHTASY LRLWALSLAH AQLSEVLWSM VLSMAFSLNT WLGGPVLYLV
     FWLYGMLTFA ILILMEGLST FLHVLRLHWV EFQSKFYDGH GYSFKPFAFT QMKSFEIANK
     KDKNVIC
//