ID   A0A158PS94_BRUPA        Unreviewed;       579 AA.
AC   A0A158PS94;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=MgtE domain-containing protein {ECO:0000313|WBParaSite:BPAG_0001248201-mRNA-1};
GN   ORFNames=BPAG_LOCUS12444 {ECO:0000313|EMBL:VDN93630.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001248201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0001248201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN93630.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC       {ECO:0000256|ARBA:ARBA00009749}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UZAD01013293; VDN93630.1; -; Genomic_DNA.
DR   STRING; 6280.A0A158PS94; -.
DR   WBParaSite; BPAG_0001248201-mRNA-1; BPAG_0001248201-mRNA-1; BPAG_0001248201.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 2.
DR   InterPro; IPR006667; SLC41_membr_dom.
DR   InterPro; IPR036739; SLC41_membr_dom_sf.
DR   InterPro; IPR045349; SLC41A1-3.
DR   PANTHER; PTHR16228; DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41; 1.
DR   PANTHER; PTHR16228:SF7; SOLUTE CARRIER FAMILY 41 MEMBER 1-LIKE PROTEIN; 1.
DR   Pfam; PF01769; MgtE; 2.
DR   SUPFAM; SSF161093; MgtE membrane domain-like; 2.
PE   3: Inferred from homology;
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        147..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        222..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        277..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        318..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        353..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        387..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        478..498
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        510..537
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        549..572
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          188..332
FT                   /note="SLC41A/MgtE integral membrane"
FT                   /evidence="ECO:0000259|Pfam:PF01769"
FT   DOMAIN          419..565
FT                   /note="SLC41A/MgtE integral membrane"
FT                   /evidence="ECO:0000259|Pfam:PF01769"
SQ   SEQUENCE   579 AA;  63943 MW;  4059FBAC18C96AEF CRC64;
     MRKSYITQNG FNFKFNRRQY DESKLLQVKR RRFRGENSKM DVGNVNSDLD GLETKFELNS
     ISVSASRGGP SYKPEVTDSK FNNDIVTDSI PMLKRMREML NSNIARGETS LVFNSGDSIQ
     VASDEDFSFT HANILDSSMS TTSSYSLFLQ ILFPFVPAGL GMVFAGFVLD IVQHWNLFIE
     VPETFILVPA LLGLKGNLEM TFASRLSTLA NMGRMNSNPK KIIVANLALI QVQAIVVAFL
     ASSFAVTLAW IPKGQVILLI SESANVKFQI DWSHASLLCA SSLTTASLTS LVLSTVVICV
     VLISRYFDIN PDNIATPIAA SLGDLTTLGA LSLLGNCLVL KRSIFLHAHL NDTWLNVGVI
     VTFIMATPFW IYLARKDKGT VDVLENGWSP IIFSMLISSA GGFVLESTIK RFPKIAMFQP
     VINGVGGNLA AIQASRLATF YHQHCPFGTL SDTLSSRFSF RRAFFSNGKH IDAHSARVLL
     LFVVPCHMFF NWIIQILHKG SSLPSGSLFT SIYICAALVQ VLSLLYVCQL LVAFLWSIRM
     DPDCAAIPYL TALGDLFGTF LLFLIFASLS WFNKGGNLR
//