ID A0A158PSX1_9BILA Unreviewed; 950 AA.
AC A0A158PSX1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=P/Homo B domain-containing protein {ECO:0000259|PROSITE:PS51829};
GN ORFNames=BTMF_LOCUS5956 {ECO:0000313|EMBL:VDO20518.1};
OS Brugia timori.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=42155 {ECO:0000313|Proteomes:UP000050602, ECO:0000313|WBParaSite:BTMF_0000784201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BTMF_0000784201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO20518.1, ECO:0000313|Proteomes:UP000280834}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
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DR EMBL; UZAG01015459; VDO20518.1; -; Genomic_DNA.
DR STRING; 42155.A0A158PSX1; -.
DR WBParaSite; BTMF_0000784201-mRNA-1; BTMF_0000784201-mRNA-1; BTMF_0000784201.
DR Proteomes; UP000050602; Unplaced.
DR Proteomes; UP000280834; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884:SF3; FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000280834};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 93..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..901
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 692..843
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 352..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 342
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 383
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 587
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 950 AA; 105736 MW; F10224A42E6F5B51 CRC64;
MALSRKCANP TYKHSVWDNQ KSAHGIYRVK INNETSVHTL NSVAKNELAC CSNADVFKFP
IMNEENSVLK GNCTTYQICP LDRNYRSLSR QHFRIPVTSL LFIVLSLAFL SMPQFSSVAA
DELNSSDAVI ELTPVGGSNN HNNGSYGTGT SQSSSTALRK AYTNQFAVRI TGGDTLEADK
LAAKYGFINL GRVLPNDEYF LFESRQTRKR STRRRRNAQT NSIAREPKVE WIEQQIAKKR
VKRDYMLMNT LSSTVHLQRF KGNEISDDLT IIGSDDVQQQ YASSRNRNAD IRSVGNYNLN
DPLWSDMWYL NAAAYDRGLD HNVREAWDLG YTGRGVVVTI LDDGLERTHP DIAPNYDSKA
SYDVNDRDED PTPRYDYTDE NRHGTRCAGE VAAIFNNSLC IVGIAYNARI GGTILPEFIQ
AYRSKKMFFG EKTSTKSQLL IGIRMLDGDV TDAVEATSLA HNSDHIDIYS ASWGPDDDGR
TVDGPAKLTR RAFEKGIREG RRGLGSIFVW ASGNGGKDAD SCNCDGYTNS IYTLSISSAT
EHGNIPWYSE ACSSTLATAY SSGATGEKMI VTTDLHHSCT NAHTGTSASA PLAAGIVALT
LEANPXXXXX XXXXXXXXXX XXXXXXXXXX LEANPKLTWR DMQHIVVRTA RPLNLRAGDW
VTNGVGKKVS HSFGFGLMDA GAMVRLANNW TTVPEQRKCV VFYPARYKLN SLSFNLYFFN
ILLFRIVPHG NRLQLQLYTD GCSSYSRNKV GYLEHVQAII TLTAPKRGDI QIYLTSPSGT
RSTLLAKRAR DTSRTGFREW AFMTTHNWGE MAVGLWTLEI NNDGWDDAEL IRWDLVLYGT
ATEVSNIGGT PSASSSSLTP RSLSSKVRNR YGALWEDTSA ASIITASNII ALFFLLCFIY
LNFPSAEKSV KYYFGVFLLP ANVSLRHSDY FMVPKCYRLG CLTFNLKSEQ
//
