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Database: UniProt
Entry: A0A158PYE4_BRUMA
LinkDB: A0A158PYE4_BRUMA
Original site: A0A158PYE4_BRUMA 
ID   A0A158PYE4_BRUMA        Unreviewed;       799 AA.
AC   A0A158PYE4;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   28-FEB-2018, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|WBParaSite:Bm2484a};
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279 {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm2484a};
RN   [1] {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm2484a}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|Proteomes:UP000006672,
RC   ECO:0000313|WBParaSite:Bm2484a};
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J.,
RA   Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D.,
RA   Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M.,
RA   Wortman J.R., Feldblyum T., Tallon L., Schatz M., Shumway M., Koo H.,
RA   Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J.,
RA   Carlow C.K., Crawford M.J., Daub J., Dimmic M.W., Estes C.F.,
RA   Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J.,
RA   Komuniecki R., Korf I., Kumar S., Laney S., Li B.W., Li W.,
RA   Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
RN   [2] {ECO:0000313|WBParaSite:Bm2484a}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
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DR   EnsemblMetazoa; Bm2484a; Bm2484a; WBGene00222745.
DR   WBParaSite; Bm2484a; Bm2484a; WBGene00222745.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.20.120.350; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01470; ERGCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006672};
KW   Ion channel {ECO:0000256|SAAS:SAAS00920127};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    132    153       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    273    297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    339    360       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    367    391       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      470    570       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      652    679       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   799 AA;  90022 MW;  7AA4576FCC86C58B CRC64;
     MNLHQSELLT PVPESDTEGE SASTRITSSP TLLSSNPQEN HLLHPLSNYA SRKIGRQEPS
     SFHHQQQQRI GHRPSFMRRL SAAIPSLSTD SMPFAAVLSL GADVLPEYKL QPTRIHHCTI
     VHYSPFKAVW DWIILLLVIY TAIFTPYVAA FLLREDSSRK ARFSEPLEII DLIVDIMFIV
     DIIINFRTTY VNENDEVVSH PGKIAIHYFK GWFIIDMIAA VPFDLLLVNT NSDEIGGLNK
     DETTTLIGLL KTARLLRLVR VARKLDRYSE YGAAVLLLLM ATFALIAHWL GCIWYAIGSA
     ELPHKEFTWL HQLARHLNEP YLSTNGSVPT GGPSLKSRYV TSLYFTLSTI TSIGFGNVSA
     TTDSEKIFTI IMMILGSLMY ASVFGNVSAI IQRLYSGTAR YHTEMSRLRE FIRFHQIPNP
     LRQRLEEYFQ HAWSYTNGID MNTVLKGFPD CLQADICLHL NRNLLNNCPA FAGCSPGCLR
     ALSMRFRTTH APPGDTLVHR GDVLTGLNFI ARGSVEILKD DMVVGILGKD DIFGENPLLH
     EDVGKSSCNV RALTYCDLHR ILRDDLLDVL DIYPEFAENF CRNLTITYNL RDEAQSMRKR
     LDRHKLLRMS SSLDKDKISS IQREGSLEKR DDFVTRTERT MSNRSEDDDI RYQMLERRLS
     DIESHLEKME NKINSSLEQI LRVLIPENAL INSSSGRSSK GTSVRTIYSS RSASGIHPVR
     LGNRNEELIP LRMPTSYSGI DDVNSPLIGT STTPPILLST TSRSLQPRRS GHLSLVSAPS
     GQSTPTRSEL SPEDTDTLL
//
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