ID A0A158PYG1_BRUMA Unreviewed; 893 AA.
AC A0A158PYG1; A0A1I9FZZ0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=BMA-LIN-35, isoform f {ECO:0000313|EMBL:CDP91408.1};
GN Name=Bma-lin-35 {ECO:0000313|EMBL:CDP91408.1};
GN ORFNames=BM_Bm2523 {ECO:0000313|EMBL:CDP91408.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDP91408.1};
RN [1] {ECO:0000313|EMBL:CDP91408.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP91408.1};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDP91408.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP91408.1};
RG WormBase Consortium;
RA Ghedin E., Paulini M.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR EMBL; LN856402; CDP91408.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158PYG1; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051172; P:negative regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742:SF36; RE32990P-RELATED; 1.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 84..209
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 385..585
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 671..754
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 763..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 102381 MW; E1415FC9C05DB785 CRC64;
MKSETSSKSP TGQSETVDNL QVEPSTTFLY ICKQLDPKID EDFIEKAWKQ YDTVGKQYVL
EGKQLTWYAC AVYLSMWQGS LLENAVPKKY SLAKLLKICK LSVLEFFDKG TKWVEMINGP
RRLKDHISRV QSSLAVSAVV FKKLLPIFRK IFAPPYSNDD EDDVKGLNCK KLFSLLWTLF
IVMRKQFNSD DLMNSFHLLL CTVDFIFQDL RRSEMTCLLD GDFINAVDIQ HEEDSILETL
CQIFEGVVLD AKHFRTHCWL PKMRRMSEEK TIETGEDLTN FAANEFINKK KLDSIYEELI
VKRGEMDERM FLPADISIVF DEAYDECAVQ RLRRSEDGDN LVDADMLLRI STQSCLERLQ
DQRQQRTPLS GRGYVISAEQ YCPATPVSAS LYNASKLEAL LQDNWRRLDA EVESILCHSC
QDPFEKIMNI VSQLSERLEE VIENEGRLDG AGYDASFRQM FAVRKNNTES LFFRFLHKIA
FSERDRLGSG SIVKLSAVLL REDFLKALYV CALQLVLFTY ESVREFPWSL EIMRLPAIHF
YKVIELIIRA DSSLSREMVK HLNKVEERVL EEFAWSLDSP LWPSLHRRTD GVPSSQAVSL
ETLEGYSVRQ PSLSQRYTLS PVKPLAKRRL EFDDDDSSCI AAKRRVPDAE NSTPTSATLL
FFRKVYYLAA VRLRDLCERV RLDEKGRQRA WTLFEHVLRT ETSLMAGRHL DQNLMCCLYV
VAKIGQQNIS FHDIMYHYRH QPQATSRVYR RVLVENTSSP PIILDDGASH DSVGSASGDK
FRSESSVSGA VTGSGTATPE HQNVEYIDLI KYYNHIFIAH VKSFVQKLQP GIAESGVSLL
SIPVVHCNRL SPQRSVSDRI TVTPMPTSLP SSPSRPYRYI FDKTPVKVGT KFN
//