ID   A0A158Q2S2_DRAME        Unreviewed;       411 AA.
AC   A0A158Q2S2;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=TWiK family of potassium channels protein 7 {ECO:0000313|WBParaSite:DME_0000074201-mRNA-1};
GN   ORFNames=DME_LOCUS5102 {ECO:0000313|EMBL:VDN55129.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000074201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000074201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN55129.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC       1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC       ECO:0000256|RuleBase:RU003857}.
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DR   EMBL; UYYG01001151; VDN55129.1; -; Genomic_DNA.
DR   STRING; 318479.A0A158Q2S2; -.
DR   WBParaSite; DME_0000074201-mRNA-1; DME_0000074201-mRNA-1; DME_0000074201.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR003280; 2pore_dom_K_chnl.
DR   InterPro; IPR003092; 2pore_dom_K_chnl_TASK.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR   PANTHER; PTHR11003:SF333; TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 7; 1.
DR   Pfam; PF07885; Ion_trans_2; 2.
DR   PRINTS; PR01333; 2POREKCHANEL.
DR   PRINTS; PR01095; TASKCHANNEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003857};
KW   Ion transport {ECO:0000256|RuleBase:RU003857};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958};
KW   Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003857};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        117..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        150..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        228..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        252..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        280..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        322..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          108..175
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
FT   DOMAIN          234..304
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
SQ   SEQUENCE   411 AA;  47837 MW;  377725FD8697BAD8 CRC64;
     MDEEMEVQGF KKYAKLILPH VGLVVLTCAY TILGALIFYS VEHPNEMLTK RHQLDMIYNR
     QEEFVNSLLK LSQSNETRSE IWIKLTHEHM HNMSDHLFTA FEKFFLTSTE VRMNDTIQIW
     SFSTSIFFAV TVVTTIGYGN PVPVTRFGRM MCIVFSLFGI PLTLVTIADI GKFLSEHLIW
     IYGHYLRLKK KMLRMHKRRH RQERVCEQCQ RQGISAGMQL IEEQRIPAFL VLTILVLYTA
     LGGILMSHLE PWSFFTSFYW SFITMTTVGF GDLMPRRDAY MYVILLYIIL GLAITTMCID
     LVGVQYIRKI HYFGRKIQDA RSALAVVGGK VVLVSELYSN LIQKRAKYQS REAFIIENLY
     ITKHIIPFIP SDIRWIRYID QNTDSLSSSS TSLEVQSCRF CHSRFSISHH T
//