ID   A0A158Q3S9_DRAME        Unreviewed;      1426 AA.
AC   A0A158Q3S9;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000310101-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000310101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC       {ECO:0000256|ARBA:ARBA00010769}.
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DR   WBParaSite; DME_0000310101-mRNA-1; DME_0000310101-mRNA-1; DME_0000310101.
DR   Proteomes; UP000038040; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00892; PIKKc_ATR; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003152; FATC_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR003151; PIK-rel_kinase_FAT.
DR   InterPro; IPR014009; PIK_FAT.
DR   InterPro; IPR012993; UME.
DR   PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR   PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR   Pfam; PF02259; FAT; 1.
DR   Pfam; PF02260; FATC; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF08064; UME; 1.
DR   SMART; SM01343; FATC; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51189; FAT; 1.
DR   PROSITE; PS51190; FATC; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          446..910
FT                   /note="FAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51189"
FT   DOMAIN          1056..1381
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
FT   DOMAIN          1394..1426
FT                   /note="FATC"
FT                   /evidence="ECO:0000259|PROSITE:PS51190"
SQ   SEQUENCE   1426 AA;  163542 MW;  9DFC35A95E315FCA CRC64;
     LLRFRPAFND DNFFEERRIH IASLCRMMEL IKSEGTNFLD MTAGKMLAVL REALPLGELA
     IEPWKTFITT LSDETLLFLL PRIIVSIIPL FDKAQSRELL EHIFCSNRLS ITRTALVLWN
     NDKVKIDEYL PKYCESAVVS KVLSACTSML KEYSDEVSEL ALHKILLILR KNDFEDEDSR
     DMLAANLVPA LLHNISTSSS AHSRHLACLI FGKIGAVDPG RIGLLSAHGV RVDRRSKPMV
     FIDNMGQFLL ELTRRASKSF SVMLNADLQE ECSYSIQILL RSLFALKDNV GEKLWESLSP
     QCRREVAMFR FSKFTRTHIR AVSVVERHIS DAETKSLFES LYGMVHADAV FARFIMPHLI
     IVAIIENNAA YIADCVSEMI AVFQNALTHD GWPRFAAHTV FSIIDCLERY RDYRAAKRIH
     NDDTLTRMSD LIVSVLNAKS EDGTLYCIAA AEKCQCITRA LRWCEQYAIK RNGENNEIFN
     QKQFYTLERL FASLDDVDGV LGAYKMIESR WVSAIKERIL ALEANGNFWE ALPLYEKLEN
     EQMAWIKCLL RLNESRLALN SSYKVPIMNA EAVDEIRAIQ LEATWRMQNW SGLEELVDKK
     PSVSTWGASS ASLFCNIKRG NVESMNECIN LARLHLIEAL SAMTADDSDT YSQAYKYVVH
     LHILAEIEEA AKELNLIESD HIDSVNLSSL LVKWQKRYPS IMQHTTALEP ILTVRRGILH
     LVKNQNLVQL LLADYELRSG SCSFEDLYIK YKALPHVAEP SEDLYYRVAI FFDNYICLKN
     GNVNTEKISL ILRSYTNVLA QGRSHIFHVM PRMLTVWLDY AEKLDEDADQ ITTPEFDLNR
     EKDIREINAI IHNAFKRLDL YMFYTVFAQL ISRITHRNVE VFSTLKMILS KLLATYPHQC
     LWQSIAVFRS DPLTQKSRFS RCRAVYELAK RTENFSSLKF LISQYEYVAS AFIRVAEDNC
     SVGNQPSFSK RYPYLSRFFS EGYMDSSIKR DPSILVNEPF ESKDRPQIIV PLCEMLQHAV
     PIEIPNSLSQ FPVSAPPDKF KKPFDDSFAN VYIHQIDEEF VVIKSMVHPK KITILASDGN
     RYSLMCKAKD ELRKDSRLMD ISRMVNTLLR QNAEARQRQL SIRTYSVIPL QDSGGLIEWI
     PNLNTFQSIL APLMREKCAN VMDKKEWFLR WIPNGTDLEK LDRLRGEYYT RNPIICCSET
     IMQHSLIASL LIRAFTDPCK WYAARLAFIH TSAVMSMLGF VLGLGDRHGE NLLIDATNGE
     AIHVDFNLLF NKGETLAVPE VVPFRLTRNI ISGFGVTGVQ GAFRYSCETA MRVLRENQEV
     LQTVLQTFVH DPLLEWMHSE GRAQQLKQIT NTSLKRSHSS AAQVQAQEII RMITLRLKGH
     VVTPRIYRNT CDLHPMSVEG QVQRLIQLAS DELNLARMYI GWCPFL
//