ID A0A158Q4F4_DRAME Unreviewed; 628 AA.
AC A0A158Q4F4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
GN ORFNames=DME_LOCUS8631 {ECO:0000313|EMBL:VDN58658.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000474801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000474801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN58658.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Endosome
CC membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004195}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}.
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DR EMBL; UYYG01001170; VDN58658.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158Q4F4; -.
DR STRING; 318479.A0A158Q4F4; -.
DR WBParaSite; DME_0000474801-mRNA-1; DME_0000474801-mRNA-1; DME_0000474801.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0051453; P:regulation of intracellular pH; IEA:UniProt.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004709; NaH_exchanger.
DR InterPro; IPR002090; NHE-6/7/9.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF191; SODIUM_HYDROGEN EXCHANGER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
DR PRINTS; PR01088; NAHEXCHNGR6.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU003722};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003722};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT TRANSMEM 30..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..488
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 142..489
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 628 AA; 71247 MW; 4C8B3CF8D75BA4C2 CRC64;
MFKCLLLMYT ITIVIGRRRA ENIHRIDTLI LMIFVILLVL IVLTAWFFKH HRFRFIHETG
LTLCYGLLIG LLLRYTNIGV IESETINVIQ ENGSVLLEPP DYLRLEVKPP SSPKVQFHYE
LIEGFFGDKK EQIEHQVEQK AVFSPEMFFN LLLPPIIFNA GYGLKKRHFF RNIGSILTFA
FLGTTISAIS IAVIMFVFCL VFATSFSFKE LLFFGALLSA TDPITVLAVF QEMRVEADLF
ALVFGESVLN DAVAIVLSSS VDSFSSPTYF DFRALLESIV NFLTVFFGSL FLGSFIGCAN
SLITKLTVIH EFPLLESALF ILLSYLSFLL AEFVQLTGIV AVLFCAICQA HYTFNNLSVE
SQIRTKQFFE VVGFLSESFT FCYIGVSVFI SHSQKWNILF LVATLVSIIV ARAAFVYPLC
AFLNLRRVPK IPVNYQHMLF FSGLRGAMAF ALAHRNTATD NRQIMATTTS TIVLITVLFN
GGLASWIIEK LSIKLFFGLD IFYLNKNDES VDHLEGLDTA SSRASGQNPW DKAFLPRKWY
NFDAVFMKPF LTHANPSLME TMPSFFMPIA KIFTTERQMA LVIGNLPYNA IILVKIFGVV
NIYYLLFMKK NLLISSFSSN IIHHFWFG
//
