ID   A0A158Q5N2_DRAME        Unreviewed;       892 AA.
AC   A0A158Q5N2;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=SSD domain-containing protein {ECO:0000313|WBParaSite:DME_0000781101-mRNA-1};
GN   ORFNames=DME_LOCUS10181 {ECO:0000313|EMBL:VDN60208.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000781101-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000781101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN60208.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; UYYG01001205; VDN60208.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A158Q5N2; -.
DR   WBParaSite; DME_0000781101-mRNA-1; DME_0000781101-mRNA-1; DME_0000781101.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   PANTHER; PTHR10796:SF104; SSD DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        220..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        251..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        280..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        348..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        647..667
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        674..693
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        699..717
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        738..762
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        768..790
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          219..376
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   892 AA;  101061 MW;  AF08A70CA5A230AD CRC64;
     MGIIEDLELF IGSLGLIRFD EANNVRTEYS PLNAPSRIEY AIAQEFLGQN GSMDPIYMMV
     EADDGGSLLR DRYRIALANL IKRVQYNISV QYMDRIYYYT DLCEPYCEMN TAFKTFLDQY
     NDSRRASYTY PTIEIFGTQV FIGNNAYGVG LDDSNLIVSF TTAVLQFFVV APEIHKVLLY
     EWQMELHNNI KDKEFDLFKI GITSDTLVSS EVRRMGIETA PILIPSFIAM IIFVVGSSFR
     QNPSRSKPWE SLFGCFIPLM TLFTTTGITS AFGIKFQSIA VASFFLILSV GIDDVFIILR
     AWDRTNTNLD IPQRLSRTLE SAGPSVTISS VTNALSFAIG VISTTPAVRT FCIYSCTAII
     ICYFYQLLLF TSVLAIGGKR EKNGYQSLLC CRKADPQARN HFVDKLSYLQ IKTIKNWSRF
     ISSWPARIIL VLIMVIYYYI SVIGIQKIEA KISIDKMALP DSYLQGFQHV FEEALRNMQP
     ITVFIMNPGD LRDPNRLNGI KAIVNEYEHS IYSYGNKSTF FWLTQYEDFL RQVNISKAFK
     RIMNLSFYSE TGNFNYVDIP SFLRTTSYFF LSSFLRLNKT ACYEDSPDCI TSFFFVTNFH
     QVIKYNEMVP AVLEWRRIAA KYSDYEVYPY SDHSPFVDQT MQIESTVLWS VLAALFCTAT
     ACFIFIPNII SLSCAVYSVF SISIGIFGIL AQWEVDLDPL SMVALLMAIG FSVDFTAHIS
     YHYYKTTGKN ARDRLEEALA AIGWPMAQVG ISTIIALLPL YFKQSYVALV FLKTVVVVVI
     LGTFHGLVVL PAMLTAFTSG LGTSISADSS ERSSQQSHER KDSFYKTEKL INKINHEMNF
     GKQTNKKPIG KRKAFDATNT IAPISPLDTV ATSPIAYVHR ITLGRTNSFP TD
//