ID   A0A158Q696_DRAME        Unreviewed;       863 AA.
AC   A0A158Q696;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   13-SEP-2023, entry version 34.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN   ORFNames=DME_LOCUS10662 {ECO:0000313|EMBL:VDN60689.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000944201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000944201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN60689.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UYYG01001233; VDN60689.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A158Q696; -.
DR   STRING; 318479.A0A158Q696; -.
DR   WBParaSite; DME_0000944201-mRNA-1; DME_0000944201-mRNA-1; DME_0000944201.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20338; BRcat_RBR_RNF19; 1.
DR   CDD; cd20355; Rcat_RBR_RNF19; 1.
DR   CDD; cd16629; RING-HC_RBR_RNF19; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR11685:SF427; RBR-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR   Pfam; PF01485; IBR; 2.
DR   SMART; SM00647; IBR; 2.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   PROSITE; PS51873; TRIAD; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   TRANSMEM        334..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        388..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          100..324
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
FT   DOMAIN          104..152
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          604..628
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          644..664
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          816..848
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   863 AA;  95409 MW;  85730C018703D763 CRC64;
     MNCSIIDIKS LNVGEYCGQV EVNDKINCST LQTSRSLSND DSHSVDSVVI ENSDLDSGCR
     VDGDFNEPRI HSNDDGVAAQ PTVRRPAQFS QNNTSNSAKK LRECPLCFIR QSEKNFPQLA
     CCNHRSCKSC LVQYLQVEIM ESRVQITCPE CSEFLHPTDI YSLMVQHPDL IEKYENFSLR
     RVLMTDPDTR WCPAPDCTYA VIATSCAACP ELHCEKCGTL FCYHCKGPWH ASQTCDEARR
     ERGRKLRNTV PRRHRQSFGN QLKRGDIKPC PRCRTYIVKL DDGSCNHMAC AMCSAQFCWL
     CLREINDLHY LRNTFSPTGC TFWGKKPWTR KKKLLWQVGT LIGAPVGIAL IAGLAIPGII
     FGVPVFVGRK VNQRFAQHSR VRRRLLTAGS VIGSLVVSPV LAVMAVGVGV PIMLAYVYGV
     VPLSLCRNGG CGVGAASSSS DRNELDDEEI WHDLNGNQEK SRLLNEIERF DDTSLITGVS
     INSGLSSQQT HTTVRVKAEL CRRRPSIESG VLSFGEKCNY EEASTKAMAG SQFCDDKSVH
     TICSGQEAIS YCEEIASTVA LAGSVIDAKS LSDSASGRHT NQICCKDRDV SPTSHQALFA
     CDPQHKSEED RSNYSHCNQD SLPTHLEDDA NSSYEIGKLH GRAASNTSSY SSGRRNIRKV
     SHSPSDQISN LNVVNNLEKG EIELFLMNED TAIHLTNESS YSRPSSSAAI NKTSYSSTGG
     ISSQGAISNL RAAHFSDAID QSNADRFHIR ALFDAMKQIV SDDVANESDD EISSENPISN
     SFRSMLLRPY TKNILTADNE NGEGSLKGVR TITSLSSSNG SDKYRAISRD KRVSSSLSRS
     TASSSDRRRS KWRIFSIFSR KKR
//