ID A0A158Q7M7_9BILA Unreviewed; 1108 AA.
AC A0A158Q7M7;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
OS Elaeophora elaphi.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Elaeophora.
OX NCBI_TaxID=1147741 {ECO:0000313|Proteomes:UP000050640, ECO:0000313|WBParaSite:EEL_0000499801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EEL_0000499801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR AlphaFoldDB; A0A158Q7M7; -.
DR STRING; 1147741.A0A158Q7M7; -.
DR WBParaSite; EEL_0000499801-mRNA-1; EEL_0000499801-mRNA-1; EEL_0000499801.
DR Proteomes; UP000050640; Unplaced.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 2.60.120.430; Galactose-binding lectin; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR029491; Helicase_HTH.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR021720; Malectin_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR PANTHER; PTHR13710:SF120; WERNER SYNDROME ATP-DEPENDENT HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF14493; HTH_40; 1.
DR Pfam; PF11721; Malectin; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1108
FT /note="DNA helicase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007630819"
FT DOMAIN 324..490
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 510..666
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 857..937
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1069..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 126250 MW; 3ACF3D7ED4F106B1 CRC64;
MKIAELMLWF VIPFVHFAMA MDNVFLGDSI YYAVNCGGLA HTDLNGIHYQ ADPLHVGIAS
DFGSRLSIMR VDPRDAILYQ TERYHTEDFS YTVPLPKDDG EYTLVLKFCE VYFQSSQQKV
FDVLLNDEVV IAELDIFKEA EGIGVAYDRL LTFHLWRDSC ICVGVEVINI TFAQVENGVM
IYGDRRDSSG YVKITLAKAY FIFHLYPYVG VLDNPKINAF YIYRGPKTDI PPLQDVSFDE
EIEEEEGEEE FDEAEVKLRS EVSRFEDEPL VKDPYAEQDT SHMFIPYGIN PFMDTDSVPP
ANALRLLKKF FGHNSFRPLQ WPVIQNAIRG KDQIVVMSTG YGKSVCYQLP SLYTEKLTVV
ISPLISLMND QVENARSNGI QAACISGETN SNEQRSVLAS DDLRVLYITP EFALRCGSML
KQISKNINLL AVDEAHCVSE WGHEFRPNYR QLAEVRGFFG KNVPVMALTA TATQQVRMDI
ASSLELHQPI ITLVPLDRPN LYLSVRTPTS LEGLLDLLIE DERNGKHFNG STIIYCSTRI
LVDEVYECLL KKGVLCARYH AGMSAVDRRK AHECFIKDRI TTIIATVAFG MGIDKPDVRN
VIHYGAPKNM ESYYQEIGRA GRDGFPSKCI VFYKDQELTK HRYCILGEQS LKEQYKKHLL
EMLSLMERFL HATSCRRFML LSHFDECVKK EVTSAGCCDI CDQLIRSENS GVDRSLINSR
NYGDEALILL RAVNIFGGST GLGKAIDFVK GKTNVSQAKQ KSEYYGSGKH KTEVFWKELG
RILRMNGYIT ETKSSFNNFA HLISLSDKGQ NWLYGKNRPF LNSMVWKKKT LSIRRQHIYF
RILNFTKQRE WKDCDCYGEL IHSKDTTIAT RTDLAMKNNC SAHIIASNKC VQQLAVLRPS
CVQNLSIIGE MTEERQRKFG QKFVDKVVEF CTEHNISMDC TTDSALPKEI EKGMSTLNEA
CTDVYRNHVR GKLSLGDLAK LRAISEGTTA SYFVNFVKNG LPIYLSAVGL KRQHIDTVYD
TIREHGSDIS RLKPIMEALP KDFIDYNRLK IIFAILEYEY GVAEDSEKSS WNTASTENTN
KRNIPEWMKT EAPHSLQNKR KKKSNLLK
//
