ID A0A158QB48_ENTVE Unreviewed; 1944 AA.
AC A0A158QB48;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Bromo domain-containing protein {ECO:0000313|WBParaSite:EVEC_0000821801-mRNA-1};
GN ORFNames=EVEC_LOCUS7702 {ECO:0000313|EMBL:VDD92951.1};
OS Enterobius vermicularis (Human pinworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000821801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EVEC_0000821801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDD92951.1, ECO:0000313|Proteomes:UP000274131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; UXUI01009050; VDD92951.1; -; Genomic_DNA.
DR STRING; 51028.A0A158QB48; -.
DR WBParaSite; EVEC_0000821801-mRNA-1; EVEC_0000821801-mRNA-1; EVEC_0000821801.
DR Proteomes; UP000038041; Unplaced.
DR Proteomes; UP000274131; Unassembled WGS sequence.
DR GO; GO:0016586; C:RSC-type complex; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR CDD; cd04717; BAH_polybromo; 1.
DR CDD; cd05526; Bromo_polybromo_VI; 1.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 6.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR037382; Rsc/polybromo.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR16062:SF19; PROTEIN POLYBROMO-1; 1.
DR PANTHER; PTHR16062; SWI/SNF-RELATED; 1.
DR Pfam; PF01426; BAH; 2.
DR Pfam; PF00439; Bromodomain; 6.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00439; BAH; 2.
DR SMART; SM00297; BROMO; 6.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF47370; Bromodomain; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 4.
DR PROSITE; PS50014; BROMODOMAIN_2; 5.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000274131};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 68..130
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 253..337
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 423..493
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 603..673
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 774..844
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1041..1161
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1267..1385
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1509..1581
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DOMAIN 1590..1618
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DNA_BIND 1509..1581
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 21..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1399..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1466..1494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1944 AA; 221436 MW; 0666E18CFE75BE6F CRC64;
MIGKSQSPLI ATNFGHSCSK EMKRKTTGEF AEPSMKRTKR SVNSRDETDY LRQCAEVLDC
LRSYKTADGR SLCSSFLRAP SRRTDPDYFK IVRHPIDLTR IQQKIKTEEY TTFADFCADI
HLLVNNSKDY YKFIDGAPPF SSLLFRTFQA DSEEYKDACE LSELFESKRK GIIEESLELN
ALGSSSNNSW YEFFFIFVYH FAASFRFYKT MSLSRHDPES LEDEKEGDKE ESIIDSAELE
DIIASTLELT DDTGRLLSPP FRVLVSEEVT YGLNSLVKVS FQELPSYYAR IKNPIDLKTI
AQKIRSNEYH TWSDFDADFR LMCKNAKVFN ETGSMISRDA TVLLRNYKRR RSELTNPNAK
SLSAKKIKQN AVAVDELLTM EAIDDAIEGL SEDSEEDDDT ESNDDPKWRL YWAVRNEPNP
SDPNAVLSEP FLALPSKSYY PDYYNEITSP MSLFVINKKL KRGGYGSLTE LLADITLVFE
NARSYNIEGS EIHDAAIKLE KLAVSMARTM QPDNDVRFYL YARSQLVFRE EKLDINVLSQ
KAQTLANDDL PTRPRHPLMR VSNNVDFVER SSKPGRKSIS ELLCRYREKL QSLWETAYTL
MDGNRRLADA FMILPSKHDY PQYYDVIERP IDMMMIKRKT DEDKYVSSEE FIDDIRLLFG
NARTFNEPGS QIYRDATTME SAVLAAYSSL QGLPLLNPLH MKSKYGNSPA KFSTSIKRNL
NGSDSKISAS FNSLMTAPLR HSGNNPNHAA STSSGLQQTL IELFNLLKSS RDNKGRGLAE
AFLHLPSKLE YPDYYDVIKK PIDFAKIGSR ISSNHYDSID ALISDFTLMF DNACRYNEPE
STIYKDALSL QKLVLQKKRE LCKSTTNVDV AFEIRSLLTS LLASVTNHQD RDGRCYSDSL
AEVPSLLKKH GKKPEEIPFS LDQMKKNIDK RRYRRLDRFQ EDLFSLFDAA RENSRSDSQL
FEDSVELQMH YIKVRDDLTK DFLISPARHY TERTLLNAVT ELRKQKLPEE KKADDMNAEK
QSLGTKAEGD IDLESVGQGG SVYRVHDYAY VAPAVEETSS KNHIMRVERL FKNSDGETFA
RGFWCYRPEE TFHLATKKFL ENEVFFTSYF DTVTVGRLVG KCHVMSIRQY MKEKPKGFED
KDVYVCESRY MGRQLHFKKI KHWPYKSEDD NVEFEKRPEP LTSINRVASV FASKPPRANN
FDAQDADDEA SQESSCSSTD DEYLRNLPPV LDKQRVEVIV PRQDKQNLDE VEDAKKTFYE
QMEHLGRWYQ LGDFVHVYNP LKNRTVVLRI DRMWRNTESD AMFSGPCFAQ PGEIEHEPTR
MFYKRELFAV EQPDVTVPMD SIQEQCAVLL LKDYMRMRPT EIDESLVYVV EYKVSGKEAP
GNHCSLHGTA FSAAKKSLTT DTTDSSVHTA SNSAPIKGEQ MSEASAQKIK TLKAYHLSAE
VLEHEILLFK TPITMEKEMS PLLMKADSSA VPSEQADDMD ETASESLDGG EPAGKQELVS
WLASQPKLNA RSKSGYILFS AEIRKRIMQE NPEAGFGEVS KIVGIEWKKL TEEQKKQYEV
RAEYIATERA KQEAREPQQF RLQPGQIRVF MCKWQTCDFQ FDNADLLYEH VKTAHTSQIV
DGENQFVCLW TSCLKYRKEG KPFPSLPRLH RHIKEKHLSS SAKSIYPNQR SKNFYTYQQV
STTAAAPATP ATPGTTYIAV QQATPNGQQQ YAISQPPVTG YVTQAVVASS NQIVTNGFVN
GSATAYVATA TPTVVHATAG VQAYHPYPQQ VRQRLSVLVV QVTTAAQQMV ATGTPQYTAV
AVQPVGYGTA STSQQQPQAV QQQPSLPSQN TFIGDPGRSV VQTSRVPEPV FVAPPNSIQV
KRVLHSEAYL RYIESLHHGS QRTVSKWNRS VLINRRNLTS QKPLPLNWLK DARSNGMREE
ELVNALWRLR DHLMQDVANI SSGV
//
