ID   A0A158QCS0_HYMDI        Unreviewed;       852 AA.
AC   A0A158QCS0;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE            EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN   ORFNames=HDID_LOCUS1866 {ECO:0000313|EMBL:VDL19327.1};
OS   Hymenolepis diminuta (Rat tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX   NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0000186501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HDID_0000186501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL19327.1, ECO:0000313|Proteomes:UP000274504}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC         Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
CC   -!- SIMILARITY: Belongs to the SARM1 family.
CC       {ECO:0000256|ARBA:ARBA00008291}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UYSG01000393; VDL19327.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A158QCS0; -.
DR   STRING; 6216.A0A158QCS0; -.
DR   WBParaSite; HDID_0000186501-mRNA-1; HDID_0000186501-mRNA-1; HDID_0000186501.
DR   Proteomes; UP000046397; Unplaced.
DR   Proteomes; UP000274504; Unassembled WGS sequence.
DR   GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR   GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0019677; P:NAD catabolic process; IEA:UniProt.
DR   GO; GO:0034128; P:negative regulation of MyD88-independent toll-like receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0048678; P:response to axon injury; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR039184; SARM1.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR22998:SF1; NAD(+) HYDROLASE SARM1; 1.
DR   PANTHER; PTHR22998; SARM1; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SMART; SM00454; SAM; 2.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274504};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          520..584
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          703..825
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   852 AA;  96033 MW;  DE6AD96E21AB0360 CRC64;
     MDYCKTSNDQ LSRPDFFVAV FKGINYHLPD RFHRNSSPDS ADMNITYPSI SPPLETVRFP
     SRCGGSLQTT TSATSKSTSI KTSKTVASSS LTTMDGMKTV SVHSTSTKSS FSGSATSSRS
     RLIDSSSKVV ENIAEMQNLF QQSNVSESML EQIENYCQRL ETYLPQENST LISSSSSEIG
     FRFKQVKKRT NLAYLRLLKQ LVNEVGLDAA LNSSVGVPIL EAFCSCPISE SSTAQPLCSA
     PGGEDPDGLN DRVFARTQNK ENNVPPGDKL RRAVRLLMAK GKDAAQDREL NSEFMALIEK
     MTNYNENTCQ DLIEEGGLDY VFRACRSEDT EAVKHAVQTM ANLLHRVGRD HQYEMMRRNT
     FVWLFMLAMH SNEEIQYYAF LIVTILSNNR ELDAVLDRSQ LISLMIPFVK RHDVREFASR
     NFTDQTPIFS EDWLIFILPA LTSESRVEVQ AFTAFHFAIA AQLRANLLKE LAPASKAKIE
     SALVKVSGLK RDPAWKLAAH ALDKMGSKVP KALSLHVFNW PTEDVICWMN REGFEAVAEK
     SKILMIDGDI LLGLTEKELE EGLGITNCIT RRRFLRQLSH LKSIANYSQI DPTGIADFLA
     EASEDNQESG SMNNSDSSND NNRSKDALFT ISTVDTSIPT ALLTQYTYNL LSHGITRQRL
     ADLVEEDLEH TCHISDGIHR KQLLKAVQNA TSGGNTARDD IENRIDFFIS YRRSNGTHLA
     SLVKTLLQLR KYKVFLDIER LKGGRFDHKL MDSIRRSDNF ILVLTKGALD RCTTDGSPDW
     VRREIKCALE SNCHIIPLSD RFDWGNTDNI PEDIRTITKF NSVQWTPEFE EGCIDRIIDF
     MKPNLHSEER RK
//