ID A0A158QKZ0_HAEPC Unreviewed; 887 AA.
AC A0A158QKZ0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Importin N-terminal domain-containing protein {ECO:0000313|WBParaSite:HPLM_0000550801-mRNA-1};
GN ORFNames=HPLM_LOCUS5500 {ECO:0000313|EMBL:VDO26206.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0000550801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HPLM_0000550801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO26206.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO26206.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC subfamily. {ECO:0000256|ARBA:ARBA00038423}.
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DR EMBL; UZAF01016348; VDO26206.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158QKZ0; -.
DR STRING; 6290.A0A158QKZ0; -.
DR WBParaSite; HPLM_0000550801-mRNA-1; HPLM_0000550801-mRNA-1; HPLM_0000550801.
DR OMA; AQEGAMS; -.
DR Proteomes; UP000038042; Unplaced.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000268014}.
FT DOMAIN 47..115
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REPEAT 436..474
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 887 AA; 99519 MW; B8AE98B465CBAAA2 CRC64;
MTSWQPNQEE LTQDFARTFL AFKFVLTQVL HLLHHSQSTD TVVQRNVQQQ LDMLNGHQSF
CCYLVHILSG MKEEQEASRS LAGLILKNNV RSQWSKYPDE VREFVKTNTL ASIADPSPLI
RATVGIVVTT IVVEENGVGH WPTLLPYLGH LLDQPDPNMQ EGSMGAIQKI FEDSGDRLDT
EQHVHPLMPK ILSFFSSESP KMRGLAMNSV NSILMINNDP INAVIDDFLQ QLFGRAHDQD
SEVQKQLCRS LTLLLDSHFE KLAPHLPNVI DYIIMKTQDA NENIAVEACE FWLSLAENSD
VCKELLSPFL GKLVPVLIKC MRYSESDIIA LKGNCDEEDA MIPDRDEDIK PRFHKSKLAA
GQLNGEVSFE KTRRCSAASL DVLASIFKQE LLPILLPILK EALCHQEWEV KESGILALGA
VAEGCMNGIT PHLHELVPFL LNMLDDKKPL VRSITCWTLS RYCSWVVDEA RQQYFELTLK
GLLVRVLDGN KRVQEAACSA FATVEEEGGD FIAPYLSDIL QTLVQAFGIY QAKNLLILYD
AVGTLANSVG SALSEPMYVQ VLMPPLMEKW QRLGNDDKEL FPLLECVSSV ASAMGIAFLP
YCEPVYTRCI TLITQSLRQS VEAQQRPNEV EMPDKDYLIV ALDLLSGLAE SLGSHIEPLV
GRNEVLQLLS LCAVDPTPEV RQSSFALLGD LTKACWHHIK PYTQTFIPIL AMNFDPSHIS
VCNNAIWAFG EMSLKMGAEM KQYVLSILPH LIRVMNQKDG QRTLLENTAI TIGRLGTYCA
EEVAPHLVTF IRPACFSLRN IRDNAEKESA FRGICYMINL NPSGVVNDFV FLCDAIASWT
SPKPELKEMF SRILNGFRTQ VGIENWTAFT SQFPPPLRER LAAQYNV
//
