ID A0A158QLA3_HAEPC Unreviewed; 4188 AA.
AC A0A158QLA3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Cadherin domain protein {ECO:0000313|WBParaSite:HPLM_0000609301-mRNA-1};
GN ORFNames=HPLM_LOCUS6085 {ECO:0000313|EMBL:VDO27944.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0000609301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HPLM_0000609301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO27944.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO27944.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; UZAF01016436; VDO27944.1; -; Genomic_DNA.
DR STRING; 6290.A0A158QLA3; -.
DR WBParaSite; HPLM_0000609301-mRNA-1; HPLM_0000609301-mRNA-1; HPLM_0000609301.
DR OMA; YSSLYYE; -.
DR Proteomes; UP000038042; Unplaced.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 28.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 30.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF445; CADHERIN-87A; 1.
DR Pfam; PF00028; Cadherin; 15.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 29.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 31.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS00232; CADHERIN_1; 6.
DR PROSITE; PS50268; CADHERIN_2; 29.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..4188
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041081543"
FT DOMAIN 36..155
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 158..274
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 374..478
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 488..612
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 619..718
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 732..866
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 867..978
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 998..1104
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1103..1212
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1209..1330
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1332..1432
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1433..1538
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1539..1642
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1643..1738
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1739..1851
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1852..1957
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1955..2058
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2139..2240
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2241..2341
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2390..2474
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2475..2576
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2606..2709
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2710..2829
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2838..2933
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3104..3160
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3161..3295
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3296..3399
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3400..3502
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3511..3602
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3881..3918
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3931..4104
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4108..4144
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4146..4182
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 3908..3917
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4077..4104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT DISULFID 4134..4143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4172..4181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4188 AA; 460023 MW; CF58711CFA0458CB CRC64;
MKRHNHLFLL LHLVALGLGP LFARQHSLVQ IPFVFTAKLY NISLEENAPG TEFARSSDHI
RIGVPLPHSD ATVKFKIVEG DRHHHFKAHS RQVGDFVFLR IRQKDRMDTP LNRELKDHYE
FLVKATCRQK EAGNLEATAR VHLTITDRND AMPIFTLEAD QYEATISDQT APFSDVIRVE
ASDADEGING QIYYSLVNRS SDFTVDPISG WIRTLRHLRS GTYKLKVRSE DRTSRLFYDD
ADQIQPAWSK DVVITVTETK RRHLKLLVAN KPINGYRSDV QQLAATIRVD ISSNEALSNG
PIHVGVVEDD LKHWFSLVES GSLEWQLYTV PGRFIPSKTN VTISAGQESP SSGMVNTTAN
IRIEVGEPHS IAFEHAAATF HVNESSPLGY VIGKVSASAL YKQDEKDIRY YLEMSDNATV
PFEVSEKTGV LRVAQLLDYE KQRDYTFNIL AKLAGFGGQS SIVVTVLIKD SNDHSPVWAA
KWNRQGPIAI SNGTAVGTVI LKVIRSLFAQ LFGVVDAIDL DSGENARLGY KLSSDSQVPF
AVNFETGEIS LSAPLKTGDN EWRVAVWAVD SGRPLPRSTV LNLVFYRNGT KIPAKPKPVI
GSEPANKHEP VFEDFHGPVE VEEDAAVGTA ISAISATDMD VGYGGLVRYS LWDDHFSIDS
ETGVIRVAGD LSELLPPNAA SVPHDLEVFA FDEGSPRKSS KTTTKFIIRD VNNNAPQFQE
LIYSLGTIDP QLQHWYRFHV SEDTKVGTVL LKLTATDDDG DENGKVGYRL AGGQGGFVRI
DEISGELTLA RPLDRETNDV LRWVKLFLVH LLRTIYRAHS FEGVQVLYYI ICSYAVIAFD
HGSPSQISAV NLTIEVDDVN DNAPYCIEPV TVVRIPEDYP DGAMVGCLTA YDPDVGQNAR
LRFSIEAEEN GIAPPFRIDH HSGCVFIHSP HQPLDFQRRS IYNLSIDVGD NGETVLSTNC
SFVVELEDVD ENLHPPEFDD IALEASVYGR ELSERFMEIE KKSPSFSENM PIGTDVLAVK
ALDPDNPSAL LDYNIVGGSG MAFFAIDSSG TIRTSKVLDR EQQSTYWLTV EANDSPQARV
AKAGVLHVFV RVLDRNDHRP VPVLPIYQAN VKENSPQNVV VVKIDATDGD DIDPKSPSSL
HYKISKGDPQ SFFRIDQYTG YITTSGSRRL DRETQREHEL WVSVCDSGEP QLCSSVPVVV
TVEDVNDNAP TFTQPIIHHN VPAGVAGRLS RVFANDIDSG KNAELFYNIT EGDPKFSIDE
NGYISTSTPM KPDEVAFGFS LSFRFAQVAT LTIQATDRGA PAQMTQTRAI LTAIPAPVKA
KGSVNRAPQF AKGMSRKVRV SDADQVGFTI GKFEAVDPDG DAVWWSIVSG NINETFSLKA
DSGLLQLAKS IENLPYNEST IVLSIRISDG LLEDITEVAV ELSRSPLSRP IFSAQHYKTQ
ISEKTAVGTQ IYTVRARSSG VTRSSKPLLY GVHSVEDTGM EDKLRVEPTT GSVLVMEALD
YEVCREIRAI VFARQGTLTS YATLTVTITD DNDNAPRFAH KDYVVALPSS SPVGSSVATV
LAHDADSGEN GLVEYSIISG NQMGLFTLDP ILGVIAVAKR LPAEHKETIL TVRATDHGRY
PLSDTSNVRI QSMAMDELNL RFSRALYQRT VRDSVPLGSV LLTLATIPNG NARYSLKRPC
PYFDVHPASG AVSLSRWLTK ERAKSVACTA VAKNRAGSED TAKVVIKIAS TNQHSPIFKQ
QFYRGFIREN SLSGSSVLLD NNTPLLVSAT DKDVGPSSLI GYRLLNPNEP YFVVDFVTGA
IRSRKPLDYE KLKEWTFHVQ ASDMGEPVRS SPIPAVVHVT VLDTNDQKPA FTKTKYEVDL
ILPTVPGVVV AAPAAVDEDT VGKLRYAIKG NTHAKFFSMN STDGSITLLK SDPKSLNLAK
YVMDVLVSDG VHTDTATVEI SVRKISTDAS GFRFPLVEYQ ANVKENATFT PGESLIAVTA
VGAPEGASVT YRILNEREEV FIHESTGMIS LTGKPFDREE EPVVRLLVQA QTHEVKPQLA
QTVVAIRVDD INDCAPIFVG LPYDVVVSSD SVIGERILAV KAIDKDIGSN EWDRTLSQRL
APQSLQAEQA RWKDHGEPPL KTVQVVRVDV VEKARPIFTK KHYEATVSEA APRKTIVSKV
KAASNVGGHL VYTIEEGNDD DLFVIDMDSG VISVNGELDA EERAAYNLTV MVRDVTRNGL
NSTAVINIEL TGVNDNGPRF EHLVYRVNVS EAAPVGTKLL TVKAVDPDGE NELISYAVTG
RDSSIVHMDS ATGILSLAQL LDFEKRRRYE MSLAAADSSQ LVGKSKLVLT VEDVNDEPPR
FSTPFASAVV SDTATAGQFI AILSVTDDVG LLWNGFLEWL RLSALHSLFK DTVSSIKGGH
RFFYSVIEGD ETLFSVAEHS GEVSLLRPID ADDTLSGGGQ KTLNVSVSDG LFTAYGQLTV
SIVMSGNRHP PPRFEQSQYV IDVRENNVLT NKTSILTVQA LDGVPPLHYS MGGGDNRQKP
LRIEKLTGRI HPKIVFTYHL QQIYKVPLVV EDALGRKAFS TLTVNVMDVN DSAPVFVVGK
QTSFSTFPVS LDLPFNNLFA VSAKATVFRY SATVSANARE GETLLMVSAS DDDSDDTVEY
SLMGDDHITQ SFRIHPRHGT LSLVKTLDSL VGSSLNLAVR ATDQANPPHH ANAQVSISVL
PDEVAIPKFS SSHYLFVIPE DSAIGTVIGK LQQTEGTRLL LLLFSLSGRL YILFIADVSD
VRFSLLDAPA DFPFSVERAT GQLLVSRSLD REMKEVWRFV VRADAANSAH SMAMVTVRLS
DVNDHAPSFT GAYDRLVISE DAPVGTTVAV FSAIDADRSP GGRISFSLVE KAERNKAFTV
DAESGWLVVA APLDRELQPV AELVIRATDE GGLFTDHAFK IEITDVNDEA PQFDENFYIV
YVDSSVLTVG QIVARVVVTP NASHALLDRL QDQAVIVVDF YREIIICEIK DKDLPPFNNT
RLFISRGNDD GLFAIDDSGK ISIARLSQLR HISPESVELS PELSTSQITL NSGTTSTFEC
DPEKEILIEV REDISLNKEI YREESPVLLP GKRYLLLSSE VLPFAIDPNT GSISVKGVLD
AESRKKFVFT RQLELKSMAF SCSQPVEVRI IDVNDEAPVF TKTELTVSIK ENEPASESER
SFVVRVHAVD KVGGHSASCN MWPFCLVVNL RIYGYVQDSG AFGRVQYSLA SDHGGTFVID
RDTGAITVTR PLDREQTHEY LLHVVAQDSD PVNPKSAKAM VLVSVLDQND NPPLFERSEY
VLQVMESESI GYTLATVHAE GGDAGETVRY KLAENGTHNG YVTLDEQKGI LTLAKGLDYE
KEKLLSLTII ATDSGSPPLS SEAVVTVQVL DENDNIPKFM KESYKATIDE NSPVGTKVVK
VRAEDADSEH YGRVAYSLIK DDANLFQIDE QGLITVAGPL DRETRPYHRF EVEARDGGEP
PQKSTVTVLI DVNDVNDNAP VFADCNMTAV EGVLPGHTLL PLSITDADGS NFGEPFRVEV
RGEGAKAFRV DDQYNLVTVT RFDHARRDRF LLTLIAYDRG NRSTDCPLTV FVKEESRHPP
RISPLRISLN TLMGEFKGGV VGTVQASDED AGDMLRFSIV DGSVLGPLPT DAHPRPHVVK
PHLFRVDANT GEVWSDHGIP GGLHAFNVSV TDGKFTTVSY VEVLVTSLEQ DAVDHAVAVR
LKGMTALEFF EKYAAKFKAV FAQHLNVDAR NIQLLSVQET PQTRRPRSVV PDSKHTDLDI
LFTVSRGGGR GMLKPDHVYT RLKHDFQSIV DESGTMKYQL TTEMCTPGVC QRGECRERVY
LDDQQQTVVS TGGVAFVAPN HHRVAECICP EGYGGSRCEQ EINACARSPC HPWEMCLPSE
GSRFECVCPP GSSGDKCSQA SCANEGRCLE EAELSVGGSG YFEMSIAHEM ETRMELEVEL
KTTSLMGVIL HAHGPSDYHM LELVNGRVLY RWDAGSGEGT VATDTSIADA QWHRVSVSRR
GRRTRLQLDG VDTKEGWSPA GSDVINLYSA SHRLFFGARV ERENSSSVSI TKAIVACFRA
ISIDRRSVAK TRQGLRLYSA STGCRAMAAT PCSEAPCRNG GTCQVIDKTY QCTCPTRYSG
ANCEIDMDPC GSRPCPLGIQ CIPFYNEYLC KCPNGFTGKR CEIRGYGS
//
