ID A0A158QLB9_HAEPC Unreviewed; 1535 AA.
AC A0A158QLB9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=VWFA domain-containing protein {ECO:0000313|WBParaSite:HPLM_0000617501-mRNA-1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0000617501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HPLM_0000617501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR WBParaSite; HPLM_0000617501-mRNA-1; HPLM_0000617501-mRNA-1; HPLM_0000617501.
DR OMA; HGDCIHD; -.
DR Proteomes; UP000038042; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR PANTHER; PTHR24039:SF40; TRANSMEMBRANE MATRIX RECEPTOR MUP-4; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 4.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00181; EGF; 15.
DR SMART; SM00179; EGF_CA; 11.
DR SMART; SM00200; SEA; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 7.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 12.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50024; SEA; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1294..1317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..41
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 62..225
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 336..380
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 429..467
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 479..517
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 529..568
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 618..657
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 664..703
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 770..892
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 928..1053
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 1055..1091
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1102..1141
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1150..1187
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1205..1243
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1250..1286
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1456..1535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1511..1526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1257..1274
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1276..1285
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1535 AA; 166833 MW; B3C54ECF71DE8F77 CRC64;
LAANQCSDRK LNSCDDNADC VQLPDGYTCK CFSGYVDVSS NANLEPGRVC TLSTVCPVQA
TDLVFLIDGS GSIGSYIFQT ETSSSITFPE HTPTIAIVAP EIGIISYLHM HYNTSLLRYL
TGLTRTGAAI EHVATEAFSE RRGARPLSDS VARVAIVITD GRSQDNVTTA ANNARRQNIQ
LFAVGVTNHV LQAELEEITG AKDRTFHVNA FEDLNTRLRS AIQRVTCPQN EAPKPSGPCD
PSSHAGCDRA LNQVCMLKNG QYSCTCPEGF EEHPVTKACG GDVCNPEIPT SCPDPEICEK
TPFGNWRCTC PADLGWRDLH TGACKIGEPP QDLSESQDEC DPADSASCGP NAKCVRGPGG
SVACQCDPGY VINIKSDKCQ KPGTCDPSVP NSCDARKKEK CLLDSNGDYT CQCDASQFYK
RHNVTEICLI DECSAGTHDC DVNARCTDTD ESFICTCNSG FLDKSPDQAR KPGRVCTQLH
NECEENRHNC SKNADCIDLP DGFLCRCKES FVDVSPNMKV FAGLDCRALV DECASKTTNN
CHEHAICIDT RDAYKCQCKT GYVDHDELRN PGRDCRKGEI LSTLMSSSKS LPKLSMFRCK
PDYHDQNPSD PGTNCKFIIN ECSAENLNDC DKKAECIDTI DGYECKCIAP YVDQMPQNPG
RVCRFNECAD PKSNDCDKNA DCIDTDDGFI CQCKQGFFDE NTDPLKTGRV CVGLVIDKPQ
ESEKTTISPN LVPCGNTFCK IDLHEVCIGG SKCDCRPGES RSSPNDKCVA VTSVPIVVRV
IDFDGEPLQY STDYSKPTSP EHVQIVEDAV KGLGEVFRQT DIAPRYVTTD INYITNPKVE
NSTWDRGLLI NGSVKLSGDE NVDRCKLFKD FAAQVFVSNM KSKIEVVYGT SCGTMFCNEA
LGEECIAGKL CGCPKGQKRK DAQSPCRVVE SFNLPLYVIR DGNNPLKYTP AIANPRDDRH
KELVDRFETG IAQSYNKTPI KNGFVSVEVN DIEEPSLRNA SWISGILYNF TTHFVRGTVS
APSMVFTDLV DYIIKKNNYE VGQSKLFISP DQMNPFTACY GSDCHPNAIC TALGKGYSCQ
CPNGYRDLNP SHPGRQCLAY VGVNECEKPE LNECSPDARC IDLDYLYKCE CISPYVNAAP
EGAVPGSVCT IDYCSDVHYC PLNSTCKNIG DQAKCDCNPG FVDLRKSDRL SEAGLGDTIC
LRLTDVNECA LGLHNCSAAA ICIDQKIGYD CKCPDGYTDG NPAEPGRVCA ALLCGLCNGH
GDCIHDSVTN NVTCSCVDGY GGQFCELAPS NAGLILMTIL ALLFLLLTLL CCLYLCARCR
CFGARGISEG SASGREILGS DYYTIPRAKL KPLAYGDEAM GHDNAAVLGA YLDDGASVSS
DGSLEEIERR VTTDVTTREI RTTTVRDEMG NVVSQSQTVL HGPFETDTEQ YAVTSSDHFR
QASGAAGATA ASVHGSSAHI SSGVQGASSM GEHMRTEGYE SDSDAGSDAG RATYDRVTRV
SQSHDFLPGG DPRTGTERRR NEVRTTTTAE EVNYF
//
