ID   A0A158QPX0_HAEPC        Unreviewed;       836 AA.
AC   A0A158QPX0;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Ion_trans domain-containing protein {ECO:0000313|WBParaSite:HPLM_0001347801-mRNA-1};
GN   ORFNames=HPLM_LOCUS13470 {ECO:0000313|EMBL:VDO49273.1};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001347801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HPLM_0001347801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO49273.1, ECO:0000313|Proteomes:UP000268014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHpl1 {ECO:0000313|EMBL:VDO49273.1,
RC   ECO:0000313|Proteomes:UP000268014};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAF01018220; VDO49273.1; -; Genomic_DNA.
DR   STRING; 6290.A0A158QPX0; -.
DR   WBParaSite; HPLM_0001347801-mRNA-1; HPLM_0001347801-mRNA-1; HPLM_0001347801.
DR   OMA; VWRLIGC; -.
DR   Proteomes; UP000038042; Unplaced.
DR   Proteomes; UP000268014; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 2.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR46141:SF2; PROTEIN CBR-NCA-1; 1.
DR   PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR   Pfam; PF00520; Ion_trans; 2.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        101..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        146..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        238..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        289..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        323..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        413..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        471..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          81..262
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          289..502
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
SQ   SEQUENCE   836 AA;  97349 MW;  3B0FF9261D285C05 CRC64;
     MDDNRKISLI QPQKKQSQVA KAAVLSSAML TRKNSSGRAG VSSFPGRESI AAISDMLTTQ
     QKKAIKPGYM ASERLELALK IACTISLITV CLHTPKTFEQ WWPLTYIVLC LDLVSVLILT
     AEVALRIHHE GMSLRDSSYV HNRWAQFDLF MFISYWLSWL LHFYQILRVN LGLFSAPYQV
     QLSLYTNWNI LSVTVQEWFG VIRSVRPFII IRLIRLAVKF KLPRARIEQL LKRSSQQVQN
     VTVFFVFFMA LYAIVGIQLF GRMDYHCVLP KSACTPALPY ASFQFLRSMV FQCFVIVFVL
     LNAIINASFV YKHDESDKIR KWYYYLIEVG FTMLFNLECL IKILCYGFRN FFRRGIFKFE
     LILCIGSSLN AIKYFYDRNY FTYFQAFRLL RLIKASPILE DFVWKIFSPG KKLGGLVIFT
     ITFVIIASAI SLQLFYAVPK LHHFHTFPQE GWTDFVVEVL RATDDKLVPF VAIYFVAYHL
     FVTLIVLSLF VAVILDNLEM DEELKKVKQL RAREATTSMR STLPWRLRVF EKFPTRPQMA
     TMRRVDSEFP MPKVRDSFAH QFALEGVDME VCDQESDRSK NLLQLAPSRK YCREEPHFRH
     IGSISLRNSI AHLLEISDRT RQSVTNSLNF LPHFYRSSGS LHPRKDALPY VYRNGPNRLN
     HNDLALKSDG YRKSRTMSGK FLHTTMTAKQ MLYNENGDLS RPSDSAPKKE LKQGEIDIRA
     LQQKRHLAEI TRTRIEEDMR ENHPYFDRPL FLIGRASRLR EFCKKDSHRN NALFGLGNGY
     NNDTVVYFDA VREPMADHRR KPRHEQSLPA GTLSYFISWL SVYSFVSEND YQFSIQ
//