ID A0A158QQN3_HAEPC Unreviewed; 2933 AA.
AC A0A158QQN3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Myosin light chain kinase, smooth muscle {ECO:0000313|WBParaSite:HPLM_0001542501-mRNA-1};
GN ORFNames=HPLM_LOCUS15417 {ECO:0000313|EMBL:VDO56555.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001542501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HPLM_0001542501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO56555.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO56555.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR EMBL; UZAF01018972; VDO56555.1; -; Genomic_DNA.
DR STRING; 6290.A0A158QQN3; -.
DR WBParaSite; HPLM_0001542501-mRNA-1; HPLM_0001542501-mRNA-1; HPLM_0001542501.
DR OMA; TWRKDSS; -.
DR Proteomes; UP000038042; Unplaced.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 23.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR47633:SF7; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47633; IMMUNOGLOBULIN; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 19.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 20.
DR SMART; SM00408; IGc2; 19.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 20.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 18.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 71..168
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 224..317
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 367..622
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 687..777
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 906..998
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1014..1102
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1114..1205
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1233..1322
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1335..1425
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1439..1530
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1546..1642
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1646..1735
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1761..1849
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1858..1948
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1970..2061
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2075..2164
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2181..2270
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2413..2502
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2526..2616
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2629..2709
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2734..2824
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2834..2918
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 787..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1745..1766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2340..2363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 396
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 2933 AA; 324614 MW; B98AABB0B3BB88AC CRC64;
MEKDFNWVLR TDESLSCPEA TSKNVTTFFN AGEAQLTIKT AESSHSGVYN ITATNADGAS
TANITLIVKS PPSAPEGPIE ALIVGNSCKL SWKPPKEDGR SPILGYYIEK YDDKTKKWTF
GARSKNTTCT IDNIGDASSH RFRVAAENAA GTGLFTESEP VSLDVLPKIT RDTSKSQFVF
PEGKDAVITL SFSGQPVPSV EWTDSAGNLI KASKKIEVQE RLDSPGRPSV QQKSADSVEL
VWKEPKRNGG SPIQHYTVEM CTAATKKWKK VEAPRQSTTT LFNLLPGEIY IFRVKATTKL
AESDFSEESE PFSFKELVRE ADKVKQKIDD EIVTEPIDYE KVDSTIDPLQ QKEIDVHRLS
NDLLDKYIIC EELGQGAYGT VYRAVERATG KTFAAKMVQV RPGVRKEDVL HEISIMNQLH
HDKLLNLHEA FDLGHEMCLI EEFVSGGELL DKIIENDTLM SEEEAKDYMY QILQGLQHMH
NNQIVHLDLK PENILLKSKN ASDLKIVDFG LSRKLDPKKT VKLLFGTPEF CAPEVVNYEP
VSFSTDMWSV GVIAYVLLSG LSPFLGETDE ETLANVSAAD WDFDDPVFDD VSDAAKDFIC
RLMCKDKRRR MTVKQALQHP WIAKTPKAPK VRGQLTPQQK KKFMALKRWS DDLLPIGRLA
NRGAIFRQYS MDGVFERDIS FDEDYPPHVK KQLEDIVAYV GDLIAVLSCE MDGSPLPRIT
WFKDEKELTV PSIKYDSQFE DGLLELTVKN IELPDAGVYR CRATNELGSV YTEAKLVVGV
RETKTSPAEL KRRTEKVTEE EPKPADSKPS FDPGLVDKSV ALGDRVTLSV TSIAAAEVEW
FHNEKPIKET DSRYVLKHDK NRHELQIVSA NSSDEGKWKA VGRNKLGECE SSCNVVVKVP
DGFMAPTFEK ALEDVSCDEM ELLMLPVRIS ANPPPEITWY CDDRELQHSL NHRLQFDDDT
KEYSLTIVKA YTEDSGEYKC VARNLIGKAE SVCRVRIVEP EEKRSKKIDD SKAPKFSMHL
INPREVSEGS ELILACVVTG TPHPKITWLK DGKRLLMTEK EATYDNGVCT LTIASTILTD
SGNYICEAEN IHGKAQSETV VTVAPSIEKD QSAPKFIELL MDQTVQETDE ILLECCFKGK
PTPAINWYKD GQKLVVENRM LQYSDRKGVA RLNIMNSVPG DSGEYSCEAV NALGKDMTEC
RVKVTGVIDG AIDRSPSRSS TRSVAYSSDD TRPPLITRPL VDTTVQAGNR ELLELEVDGV
PTPAIEWYHD GKLVAENRTL RTTFDGKVAI LKIYEAQAEH QGQYTCKVSN KLGVVESRAM
LVVEPKTTNE VTNVPVFIKR IQNVTVKELG STVSLSCQAR GDQPLEIRWL YNGHLIDLEP
HYRIRSFDDG ISTLEIQGIT EDICGTYTVT ASNPHGEAHS SATVLLDQIT DKTAEPSPPT
FIIAPKSKVV AEEQSSLTIV CDITGSSSMQ VSWLKNGRPI SATERIRMER DGLTSRLVIT
SLTTEDEGKY TIIAKDEFGE VTADSEVVIT PGREVAPTVV KIVKGPPDVI KGEPIVENCT
KDSVSLSWEP PEDTHGSRIE HYKVEQRSPD QQTWTVVAMV TRPRCTIKDL PSNTEYLFRI
AASNAEGYGE SCTPVKIKTL PAGTKPHFIE LPASSFSVIE DGEFSILTKF SGSPTLSVKW
YKNGKEIAGP DANIIIDNDS SKLTIAHARS GVDDATYTCQ IENEMGQAST NVAVSVVSTK
DEVQDVDTRS DRSDKVSPGV PSVAKPLSNE TVQSGQQFIL SCRFAGKDGI AKWYHNDEKV
SSTGRYELFS SANGIQKLVC HNSCLTDAGL YRCVLTSEKG MAQTECEVFV KVAEDQAPPL
FEKELEDITT LTGKKLVLSC RATGHPEPDL VWTKDGERVA TSRRVRLEFD DKGLSELHIH
DCTAQDAGIY LCTATNISGV QSTQCTLTVA EVSGKDAHLV IAEEEKIVKP RFIRAPPSIL
EAQEGGQFKL IAKAVGEPKP TLTWKKDGRE VVRTNRPYRT YLTGDGESHL VVECVVSKTS
GIFSCIAHNI HGEAETETQV FVHRGKTSRP AAEKPAFSEH LKDTGVVAGH PVTLGCKVHG
VPEPELKWYY IDDAGNITCL TDDEHGWIEC RGGEVAELKA DCVLRSQQGT YKCVASNEHG
QASSMCYLLI GDLKDERAGP PRFLRCLRDI WTPLGEEVAF EVEVAGYPAP DLTWYHQDKK
IVEGKTVKIT YLSESVCELR VSQVSLRDLG NYAVEASNVH GVVRTVSSLN VGEPRHAEPP
QFQQVDAPGI AVKPKVAFRE EVKRSASTVR KELRRKGAAP VFIKGLEDME LEAGASAAVA
GKLKGKHRHR HSDQKGAKSG RMDARGLAAS IVAGLKIDDE SRRQSTDEQN KGNLAMEEIR
NTIQARNQHM CRPKFIVKPR PKKVLEEFKS LRLKTAISAN PTPVVHWDRE GVMLETGNKY
SIYNDGDFYY LEVHQVSIFD QGFYNCTATN SEGITTCSSE VEVVKAAEDS SVQQEKRKPK
KEMKAPDFIE VLPGKLTATA CEPLSIECSL SGYPAPAIRW LRNGNPLLPQ TERYVMSYDG
ECATLKFAFV SVADEGVYTC EARNECGETR AQVCLEVDPG DSLLADGIPP LFRTEKVRTV
MKANDGERVE LVAELVQGSE PIQIRWIRNR VVITDSESFQ YVRNGRDVRL VIADAFPEDG
GEYAVEARNQ FGTARCIMRL DIHSHERSLV EDPPRITDAT AIVRVAPGDS AELFARVSGH
PDPVVAWAKG AEAITNSVKY TLTNDGDMFS LHVNDAVRTD AGKYSLTAVN VAGEATATIE
LVVTEPTGSS AMRPRFTHAP VSVQSRLGQR VELLARFTGQ PQAVCRWFKG DIGLEDGVGG
YTIVDGADSS TLSILFLENE HVGEYLCTVR NPYGEDLANA MILIEGVFEI FSQ
//
