ID   A0A158QR03_HAEPC        Unreviewed;       533 AA.
AC   A0A158QR03;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Pept_C1 domain-containing protein {ECO:0000313|WBParaSite:HPLM_0001630801-mRNA-1};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001630801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HPLM_0001630801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|ARBA:ARBA00008455}.
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DR   AlphaFoldDB; A0A158QR03; -.
DR   WBParaSite; HPLM_0001630801-mRNA-1; HPLM_0001630801-mRNA-1; HPLM_0001630801.
DR   Proteomes; UP000038042; Unplaced.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd02620; Peptidase_C1A_CathepsinB; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 3.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   PANTHER; PTHR12411:SF895; CATHEPSIN B; 1.
DR   PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR   Pfam; PF00112; Peptidase_C1; 3.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 2.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT   DOMAIN          287..462
FT                   /note="Peptidase C1A papain C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00645"
FT   REGION          508..533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   533 AA;  60587 MW;  82197E2EAEFC46E7 CRC64;
     LLCFIIACTP QTVTKIEEFA AQPIPKEALE LTGQALVDYV NQRQSFFKAE YSPEVAEYRL
     GNLMKAHFVE QPREEGYELT TDQLIANNSD LPEKVMLGCL SCFGYVRSPL HPHKWKSEGL
     VFEMKGTNPG DSYFDSFTML SDTDILACCG KFCGYGCEGG YNGRAWKWAT ISGVVSGGRY
     GEKVTSVSFV ELITATLNQE SLLEHSKYQE IIDQEFLAQP ITKEAEELTG EALVKYVNER
     QSFFKAKYSP EVVKKRRQFL LKPQFIERSY NQENVLPIAN MTSNDDIPES FDSREEWKDC
     PSLRVIPDQS NCGSCWAVSA AQCMSDRLCI HSQGRKKVLL SATDILACCG KFCGYGGCKF
     IWIPNGFSSF LARTWYWLPN DERTIQLEIM KKGPVHATFN IYEDFEHYNG GVYIHTAGRM
     EGGHSIKIIG WGVDKGVKYW LIANSWSTDW GEDGEEFLSK SIPKEAEELA GEALVEYVNN
     QQPFFQAEYS AQAEQRMQHL MRMEFDEKHE QNAGLSKEAD PVRNDFDYDI PER
//