ID   A0A158QWV4_NIPBR        Unreviewed;      1068 AA.
AC   A0A158QWV4;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Peptidase A1 domain-containing protein {ECO:0000313|WBParaSite:NBR_0000584601-mRNA-1};
GN   ORFNames=NBR_LOCUS5847 {ECO:0000313|EMBL:VDL69436.1};
OS   Nippostrongylus brasiliensis (Rat hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX   NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000584601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:NBR_0000584601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL69436.1, ECO:0000313|Proteomes:UP000271162}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR   EMBL; UYSL01019761; VDL69436.1; -; Genomic_DNA.
DR   STRING; 27835.A0A158QWV4; -.
DR   WBParaSite; NBR_0000584601-mRNA-1; NBR_0000584601-mRNA-1; NBR_0000584601.
DR   OMA; MGTPRQN; -.
DR   Proteomes; UP000038043; Unplaced.
DR   Proteomes; UP000271162; Unassembled WGS sequence.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05471; pepsin_like; 3.
DR   Gene3D; 2.40.70.10; Acid Proteases; 6.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR034164; Pepsin-like_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966:SF45; ASPARTIC PROTEASE 6; 1.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   Pfam; PF00026; Asp; 5.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 3.
DR   PROSITE; PS00141; ASP_PROTEASE; 3.
DR   PROSITE; PS51767; PEPTIDASE_A1; 3.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..1068
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5041044660"
FT   DOMAIN          75..378
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   DOMAIN          369..706
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   DOMAIN          781..899
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   DISULFID        400..424
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   1068 AA;  118376 MW;  9D764F34658A1DD8 CRC64;
     MHVLLALLPL LGSTLAAGTY QMSLKKIESG RIRMLREGTW AAYVAKRNAL RASLVRDSKG
     EVHVQPVHDY HDTEYLGDIT IGTPEQSFLV VLDTGSSNLW IPDYQCVFHH RMRGCDDRKC
     DPGRSDQLIV PGTTIGQATH IADFFGDVNA SALLFTHQPV DGILGLAFPS LAEEGAVPPI
     TRAVDLGLIE PIFTLTEIVT AGEYGGIYTW GGVDTKNCGK EIGFVQLMKD PGYWEFTMDS
     ASVGSVKAKG GSWHVISDTG TSFLGLPSAI NDVIADQFDA TVSFTSITSA VSRRMHVLLA
     LLPLLGSTLA VGTYQMGLKR IESERIRMLR EGTWAAYVAK RNALRASLVR DSKGELHVQP
     VYDYHDYEYY GDITIGTPEQ KFLVVLDTGS ANLWIPDHNC IFHDRLRGCE DSKCDVGLVC
     KVFCPKKECC VASDINDQEM DFDPCHGKHY FESDNSTSYQ SESDTWQIRY GTEETRGFFG
     NDTVRFGAPG ADQLIVPGTK PIDGILGLGF RSLAVNDVNP PLLRAVDLGL IDPIFTVYLE
     PEEVKYGGVY TWGGVDTKNC GKEIGFVQLK KNPAYWEFTM DGASVGSVKA QGSKWNAISH
     TATSLLGLPS VITAVVAQQF NVTYKPNDDV FFIGCEKTPN VTFTINSVDY TIAPKNMVRK
     ITKSFCILPI FPTDSMGFGP QVILGYPFIR QYCNIYDIGK QQVSRRMHVL LALLPLLGST
     LAAGTYRMGL KKIESERIRM LREGTWAAYV AKRNALRASL IRDSKGEVHV QPVHDYYDSE
     YLGDITIGTP EQKFLVVLDT GSANLWIPDY YCVFHDRLRG CEDSKCDPGL VCKMFCPMPA
     CCVARYVDNQ DVDDNPCQGK HYFESDNSTS YQTESGSWEI RYGTGDARGF FGNDTVRFGA
     PGDDQLIVPG VGVNPPLLRA VDLGLIDPIF TVYMEHGGGE EGKYGGVYTW GGVDTENCGK
     EVGFVQLRKN PAYWEFMYDR FNDLFVIDCK KTPNVTFTIS SVDYTIGPEN MLIKVQEDFC
     ILPLFMMESM AFGPQGILGD PFIRQYCNIH DIGKQQIRFA PSLQRKLA
//