ID A0A158QZM5_NIPBR Unreviewed; 1785 AA.
AC A0A158QZM5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Activating signal cointegrator 1 complex subunit 3 {ECO:0000313|WBParaSite:NBR_0001036201-mRNA-1};
GN ORFNames=NBR_LOCUS10363 {ECO:0000313|EMBL:VDL73952.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001036201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0001036201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL73952.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYSL01020304; VDL73952.1; -; Genomic_DNA.
DR STRING; 27835.A0A158QZM5; -.
DR WBParaSite; NBR_0001036201-mRNA-1; NBR_0001036201-mRNA-1; NBR_0001036201.
DR OMA; MCSATEF; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0034641; P:cellular nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0010467; P:gene expression; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd18020; DEXHc_ASCC3_1; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 3.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162}.
FT DOMAIN 376..560
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 596..829
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1218..1379
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1422..1604
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1785 AA; 201772 MW; F9A7D430804CEF25 CRC64;
MKHLNEAISI SWNLAGSDKE HVQDPVRVGT DAKVSRGKPS TVSSSVINST LAALNVQPSF
VWEETNTLAY IPDEVEWNGP DFERSSIGAL VGPEVPVDTV VHQKDLSELD QPCSSSANVG
LCCADIIESL KIFFPENHET LGKHLFELVS SDKSSDELQG ELIDLLGFDH FEMVGQVLES
RDQLLREING VRSEVTALSK FAREAAARRA DGSMYCQQVV VQTKAEAEMR REIRKEQKRA
KKELNRIYHA FGDDEKLELE LAQREILRIR QLELDQLKWN PTIKGANKPR ESYPFVFDVC
AESGSAMITI NGMKYALPEG STRESFRTHE EVEVPPMNRG SVGDVHHVFV KDMDDLGQLG
FKGYEKLNVI QSIVFEQAYK TKENLLICAP TGAGKTNIAM LCILNTIHEH RMLNGDIAKD
DFKIIYIAPM KALATEMTDS FGKRLAPLGL QVRELTGDTT LSKKEISETQ MLVLTPEKWD
VVTRKGTSDN SLTSLVRLLI IDEVHLLHDD RGPVIETIVA RTLRQVEMSQ TGIRIVGLSA
TLPNYVDVAR FLRVNPYKGL FFFDGRFRPV PLTQKFIGIK KLGGIRDTQE TMNEVCYDEV
LSYVKKGHQV LVFVHARNAT AALAQAFRER AAQLGHLELF VPPTKSTRGY VMAEKSVGLE
KRYVDIGDCD KSHVQASRNS KLFEFFRFGF GVHHAGLVRH DRLLMEKVFH QGHIMVLFCT
ATLAWGVNLP AHAVVIRGTE VFDAEKGQFA DLGVLDVQQI FGRAGRPQFE NEGHGIIITT
QNKLDKYLGM LIRQAPIESQ FFKRIHDNMN AEIALGTVSN VDEAVEWLTY TYYYTRATQN
PIAYGLPHTV LDKDPDLRHH LTRMVTDVAV KLDQNQMIRF DSVNAFMHAT DLGRIASNFY
VKCETIEMLN ETGLPVSLSA FMPDDMVIAL ISMATEFSQL KIREEECLDL EELISCGCVL
PLRGGGLASV AGKVNVLLQS YISRTFVRSF SLASESLYVQ QNAGRLCRAI FEIVLRRGWA
QAANAFLTIS KCIEKRVWPN QSTLRQLDDF IRIDLIEKVE RRKLTESQLL DLSAKELGYM
FSCDGEKLYQ AMRMLPRVEV EASLRPITYT IMQVSATITP AFVWNDRLLG KTGAQSFWLT
LENIDENLIV HQEQIVINKK KVKLREPQHL VFTIPIRDHQ LSNVFQLRLA SDYYLVDDTV
VALSMHNCIL PKSYKAHTGK TLCAELAMFR LLQNNPSKKC VYIAPLKALV RERVEDWRAK
FEAKMGYKVV EVSGDYTPDI SVLNAAPILI TTPEKWDGIT RSWATREYVR QVNLIIIDEI
HLLGVDRGAV LEAIITRLKI LTRRSCVRKS PARLLGLSTA LANAGDVAEW LGIRDEGLFN
FRPSVRPVPI DVHIQGFPGQ HYCPRMALMN KPAFKAIITY SPLKPVLVFV ASRRQTRLTA
MAFISHLVAE SDPRQWLHVD MAELEVLLEH VKDENLKLTL PFGIGMHHAG LSMHERALVE
ELFVQKKIQV LIATATLAWG INMPAHLVIV KGTEYFDGKT CKYVDYPVTD VLQMMGRAGR
PQFDTSAVAV IYVQDVKKTF YKRFLYEPFP VESSLLPVLA NHVNAEINAG TISSKQNVME
YIAGTYFYRR LFANPNYYGL EDLSEKCLIS FMVGVVDQCV ADLIDSKCLI IDEEIGNLRQ
LQRKLRIRFS TSVMDSSFTK AHLLFQAHFS RTEIPTDYRT DLRSVLDQCV RILQAMRDVC
QLNGWLSTAL QITILQQMCH SGRWYDDHPL LCLPHLNIYD AERIG
//
