ID A0A158R211_NIPBR Unreviewed; 599 AA.
AC A0A158R211;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 2 (inferred by orthology to a human protein) {ECO:0000313|WBParaSite:NBR_0001479301-mRNA-1};
GN ORFNames=NBR_LOCUS14794 {ECO:0000313|EMBL:VDL78388.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001479301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0001479301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL78388.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; UYSL01021496; VDL78388.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158R211; -.
DR STRING; 27835.A0A158R211; -.
DR WBParaSite; NBR_0001479301-mRNA-1; NBR_0001479301-mRNA-1; NBR_0001479301.
DR OMA; HRERYDI; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR Gene3D; 3.40.50.2300; -; 4.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 310..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 308..518
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 599 AA; 67714 MW; 06A3DD4070245866 CRC64;
MKALFDLIAS RPRPVALFGG MCTEVNEPVA MALKYWQLYP TFFRIVPGDR NLNNAKCRLI
NHFGWKKVGS LKQSDEPRYA LPHESLTTKL EHGYGIKVVY TAGVVSMSTV HDWFKKFKAG
HYEVEDKERS GRPSVLNNDE LREQVEGDPC QTAREMSSKL GWMDGGTANC TAEDMRLVLE
GHFAIEFALV RKDNHTHSPS IWQGYLYDGL WTLAIALSQA LGANASFSHV KLLSAINNSS
FEGVTGRVRF ENNERLGLVD IRQWRNGAYE DVGFYDGVSD VFSMNTDLGG WEPPLDATVI
ERRREYISNL LFVVMSFLAL IGISLALIFL FIKMSSPNLN NLIIVGSMCT FASVVLLGID
TRILSNENFV KLCYVKTWTL SLGFTLAFGS MFSKTWRVHS IFTNIRMDRK AIKDSKLLLV
LAGLLFVDVL HSDDKVVVPE IEKCQSNHSA VFQAVLYAIK GILMILGCFL AWETRHVNVP
ALNDSKYIGM SERVNEAFAL ACFFIIFSTT LTLCLVFVPK VVELLRNPDG SNPRGYRRGM
MKSVVTHVKI RCENEKNLLA KAEAENQLRR RYVHQKSTQL WDLLEKLREL GDTQFLQQG
//
