ID A0A158R6M9_TAEAS Unreviewed; 2187 AA.
AC A0A158R6M9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Otoferlin {ECO:0000313|WBParaSite:TASK_0000054001-mRNA-1};
GN ORFNames=TASK_LOCUS541 {ECO:0000313|EMBL:VDK21223.1};
OS Taenia asiatica (Asian tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000054001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TASK_0000054001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK21223.1, ECO:0000313|Proteomes:UP000282613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYRS01000072; VDK21223.1; -; Genomic_DNA.
DR STRING; 60517.A0A158R6M9; -.
DR WBParaSite; TASK_0000054001-mRNA-1; TASK_0000054001-mRNA-1; TASK_0000054001.
DR Proteomes; UP000046400; Unplaced.
DR Proteomes; UP000282613; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF60; MISFIRE, ISOFORM F; 1.
DR Pfam; PF00168; C2; 6.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 5.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 6.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR PROSITE; PS50004; C2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000282613};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2154..2174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 196..318
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 371..498
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 899..1024
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1167..1289
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1659..1785
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1906..2055
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1337..1398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2109..2131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1374..1391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2187 AA; 247538 MW; 76041F0493ED71BE CRC64;
MSLQLDVKLL AGLSGKGQRV IKAKFRDSEL STRPANGQNA CYFGAELVWR VARRLEENDE
IVITAFDVSK YRPKKAIGSV TVNLATLAQR QVLNLEEQLV DANKMVTNVT LSFDLYYRPP
DQGEAELDID RFGHPLADLH QVRSADDLGE GDVDFGEDAM GDDKDLVELY GLGDGTAMDI
EALSDKSSVL SGPIRRDPKL KALIDPTILK SETFTVSVTI VEAKGLPGVN VNPMVEVVAA
GKTRKTDVKF YTNNPYYNKF FSFEYFLPRV AVLDELIWIR VYSLNAKMIA RILPGKLVGE
FVIDVRSIYE SKGHVLTNKW AVLIDPKKPL SGPQGYVRVD LAFLGKDDIP KHIKHEKQDE
EISLEGNQLV PKGITNLSKR NVTEFSVKIY QAEGLPPMNT DIITSIKQAF VGDSAPMCDP
YVEVSFGGHT AKTKVKKYTY TPIWNQEIVF CDFFPPLTHT IRLAVRDWEA VKDETIATHL
IDLKKILDKS SENVMPTFGP SWVNLYGSPR TYTYEQARRP DDELNRSLGE GVAYRGRLLI
AIKAQPSKDA MKTGAILRGT PPVSELVAGR KSPYLLFVAF YGVSVVDPEI GSEKMPIQFE
VSIGKSNLSI CNYGNKIDGK KGGILMKAET STKSETRAKV QWDHSLTEPM NLKSDDGLYY
YVDFGGVQPC LYLLSEFEDH RLRMCIPNII EKLKTEFVCA MDQIHHLLQR RKPGSARHRL
RQIFLYKSRI FRKAASEVRS CRGTAPKTML DLSYQRRVRS DLLRIEILLK RLGRKLTGAN
LYEAIREANA VILRLSDLMD CPQHGLPDVF VSMILDNKRI GFVRIPSRDI YYSASDTERG
KLASQVTTHF VRKPGREGVG EKGWRIQCQL RMYTWLGLVK DYLAYKRGLP EGYDPECVAG
IDPPKSLIYV DSSKFELRCY IYLAKNLLAS NKTGFSDPMA RVLINNEMLE TFPIYDTMSP
LWDLTLIKTN ITFQHKPEGV LANPPQVIVE FFDVNAPKVS NFLGRCFCEP NIVIKGADYQ
PPPLQWWQIY RGQTTAGKLL ASFDLIEIDA LDDIDAVPTV EDLADFTRRF NERVLLGPSC
GIPFSDDSDD YEEYGEQWDE EMQQAARLLE EDAMAELEAP IEESDDAYSV LSASTSGSLA
TTATTTRRKK KKAKVGLATA DLVRWRADDA LRLPENVRPP LGRYRLEVVF WGVRELRRQF
LLPVNRPVIT IEVGGTKVVS DLLRSAKTNP LFEKRLKYVD LYLPLDEKLW PPITVICHDH
RMFGVYITVG LCTLPNPTDF FEKKDLFVYD EYEESSTPIE SDTHPGGKAQ MLSKALAGLG
DPDEEEMRPT EDATLQAGRY GAPPQQPAQG SSGSGNADDE DDEDEDEYSR KGSVVESKPS
TSMTHTTGTH PGLYTERDPI LKDVPKKASS TLGSYDGQLG KAGPQAGLKA SYWRGTFPVN
PMTKLSKQQL NTLDWWSRLF ASLNDIDIGD ESAADDDLEE ADSRFDDNLE KVELLPEDVE
TEEEVVAEIP DDVVVQGGRK SRRERIRKFF RLKPKKELTA LEKFEKQKEK ERKKKAKKNK
KGKFEPKLLK KIRGDAKKAF LKELQDDVII TSAGIDTSLI ERIKIYSSEL EEVPDFQGFC
SPIRNFQLFR GKQEDDDMTA EERVVGYFKG NLKLYPVPED ADPPESVEEL HSFPTLPQIT
HWRVLVRCYI IRAFNLHPAD PTGLADPYLI VSMGKQVFNE KSNYIPKTLR PTFGKMFQFE
VEFPTTTILH IEVMDHDILG SDDMIGQTVI DLESRFYSPY RATCGLAQTY YSHSYAQWRD
NKLPTEILAE LCQKSGLPPP VYTQIDNTVK VGGKEFYADT TIVDETESTK KSNEPLALAA
LNHWDEVPGG NVLVPEHVEV RRLLHPEKGS LEQGRLMMWV DMFDRDEDKP PPPIDVTPRT
PEPWELRCII YNTAEVVLND TSLFSNEKSA DIYVRGWMLG VGEDDQKTDV HYRSLSGEGN
FNWRFVFPFK YMRYEDRLVF AQKKAFDIDP VEVKMPCDLT LQVWDNELVR SDKFLGSIAL
KLSRMPRPAK TPATCGLHQL EKSCPTLSLF ENKQIRGWWP LVIHDEEENI DIVQGKVEVE
LHLVSGQDAE ASPVGKGHDE PEALPQPDRP DSSFMGFFGP LNTIRYLIKY KLKWILIKIL
IAFLLLLIVF LLIYTSPGWI SKKIWNA
//
