ID A0A158R7D1_TAEAS Unreviewed; 614 AA.
AC A0A158R7D1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Innexin {ECO:0000256|RuleBase:RU010713};
GN Name=inx {ECO:0000256|RuleBase:RU010713};
GN ORFNames=TASK_LOCUS3630 {ECO:0000313|EMBL:VDK32103.1};
OS Taenia asiatica (Asian tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000362901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TASK_0000362901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK32103.1, ECO:0000313|Proteomes:UP000282613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Structural component of the gap junctions.
CC {ECO:0000256|RuleBase:RU010713}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU010713};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU010713}. Cell
CC junction, gap junction {ECO:0000256|RuleBase:RU010713}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00351, ECO:0000256|RuleBase:RU010713}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00351,
CC ECO:0000256|RuleBase:RU010713}.
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DR EMBL; UYRS01018306; VDK32103.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158R7D1; -.
DR STRING; 60517.A0A158R7D1; -.
DR WBParaSite; TASK_0000362901-mRNA-1; TASK_0000362901-mRNA-1; TASK_0000362901.
DR Proteomes; UP000046400; Unplaced.
DR Proteomes; UP000282613; Unassembled WGS sequence.
DR GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR InterPro; IPR000990; Innexin.
DR PANTHER; PTHR11893; INNEXIN; 1.
DR PANTHER; PTHR11893:SF36; INNEXIN; 1.
DR Pfam; PF00876; Innexin; 1.
DR PRINTS; PR01262; INNEXIN.
DR PROSITE; PS51013; PANNEXIN; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|RuleBase:RU010713};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Ion channel {ECO:0000256|RuleBase:RU010713};
KW Ion transport {ECO:0000256|RuleBase:RU010713};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Reference proteome {ECO:0000313|Proteomes:UP000282613};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00351};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Transport {ECO:0000256|RuleBase:RU010713}.
FT TRANSMEM 109..131
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT REGION 185..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 614 AA; 70806 MW; 9BBBEE9EB608E6F7 CRC64;
MDTRIIDGIT NSSASIGEDR SCPDDDFVDR VNHTYTMNLL MFFTAIVLSR QLVGKPISCW
IPNDFTGAQG EYAETVCWVT STYFIPPAQA TVPIEEDIRY EKKIYYYQWV PFILMIQAAL
FVLPCIVWRL FNTQSRINLR TVMEVSSDLK NLNDSLDQRR DLINCLVRYL EDALAIRHFR
RQRRGKKTRA TDQQHYGKGW SQLNTAGSKA DERRGTSGRR FSTPVVPLTF SKQVRVPGPR
PCMPTSSAYL SGLYLAVKIL YLANSTTQLV LTGKYLNGEA FIFGIETLRD LMNTRFWDQT
GSFPRVALCD FELRRMGSNQ HRYTIQCVLR INIFNEKIYI FLWFWFFLIS LLNLLSFLRW
CYKLLLSSVR VLFIRNLICI YFNIAAAKSQ LPSKILLDNK DKEKQQCQFS IADVFKTRDE
LQASRVFSED ILGQDGVLLL RFINMNVGPS SAAELAGVIW IKYRKTAAFV NGTTSSGVED
FVLANMAAGE IERPPAIPPK RRRPPAQWKK KKPTIMPLSA FIYRSRHAED NDSDKSTDSS
RPTIEMLQEH RRYKPMIRKR GNYLSDDDDE NGQMSVVHEN YGPEEFLDSH DVPEPEVGQE
LEELASEYRS FDDY
//
