ID A0A158R8X1_TAEAS Unreviewed; 736 AA.
AC A0A158R8X1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 22-FEB-2023, entry version 30.
DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
GN ORFNames=TASK_LOCUS6250 {ECO:0000313|EMBL:VDK36354.1};
OS Taenia asiatica (Asian tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000624901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TASK_0000624901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK36354.1, ECO:0000313|Proteomes:UP000282613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
CC Nucleus {ECO:0000256|RuleBase:RU361195}.
CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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DR EMBL; UYRS01018482; VDK36354.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158R8X1; -.
DR STRING; 60517.A0A158R8X1; -.
DR WBParaSite; TASK_0000624901-mRNA-1; TASK_0000624901-mRNA-1; TASK_0000624901.
DR Proteomes; UP000046400; Unplaced.
DR Proteomes; UP000282613; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd10492; MH1_SMAD_4; 1.
DR CDD; cd10498; MH2_SMAD_4; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 3.90.520.10; SMAD MH1 domain; 1.
DR InterPro; IPR013790; Dwarfin.
DR InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR InterPro; IPR013019; MAD_homology_MH1.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036578; SMAD_MH1_sf.
DR PANTHER; PTHR13703:SF45; MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG; 1.
DR PANTHER; PTHR13703; SMAD; 1.
DR Pfam; PF03165; MH1; 1.
DR Pfam; PF03166; MH2; 1.
DR SMART; SM00523; DWA; 1.
DR SMART; SM00524; DWB; 1.
DR SUPFAM; SSF56366; SMAD MH1 domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS51075; MH1; 1.
DR PROSITE; PS51076; MH2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU361195};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
KW Reference proteome {ECO:0000313|Proteomes:UP000282613};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361195};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 54..178
FT /note="MH1"
FT /evidence="ECO:0000259|PROSITE:PS51075"
FT DOMAIN 477..717
FT /note="MH2"
FT /evidence="ECO:0000259|PROSITE:PS51076"
FT REGION 23..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..462
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 79310 MW; 05BB38C391599C89 CRC64;
MVLDATTACL SSHSMVMKIL GTDHEPSHSQ SRSLTQSRGH LSVNTSTSSD ACMNIVHSLM
CHRKGGESEE FSKFAIESLI KKLKDRRDEL DALIVAVTSN GATQTSCVTI QRTLDSRMQI
AGRKCFPHLI YARLWRWSDA HKTELRHLPF CHFGFDKKLD WVCVNPYHYE RTVSSALDIS
SLALSPPVER RKGKVACTRV HNLSSGVEGE EVFNKQRRHS SELQHSDTSH PTPTLRLSVQ
SLLDENPLCV PALSGGVKQE PTKNSTIAYE PSHRQQQQPT STAATVTTTA ANPLSLENVD
AATANLLNLM QWVSNANATF AAAVAAGGGG VGAHSAPPPP PPASVQALPS SHPTCSTDEA
SAVALDAAET AALLDPIAAS GGAPAPVLYP SQCSGGSGGT NNGQPAFTAG SSSSSYGRAS
QQQQQPVSSS STASLGGGWG GGGAPGGQPP PMLPPNPPPS GSLQPSQLTT QRPPEYWCNI
AYFELDQQVG ELFKVPSHYT RVIVDGYTDP SSRNRFCLGQ LSNVHRSEQS EKSRLYIGKG
VELDIVGEGD VWIRCLSEFS IFVQSYYLDR EAGRAPGDAV HKIYPGAYIK VFDIRQCHEQ
MRHLAHMTQA AAMRQAAAVA GSMQMGAVAD AAAAASAAAT ATAPMGTCEA AGVGVDDFRR
LCNLRLSFVK GWGPDYPRHD IKETPCWIEI QLHRPLQLLD EVLQAMPLND LKPTRHFFYY
QNQLQQPPPS QHLAKR
//
