ID A0A158R999_TAEAS Unreviewed; 1340 AA.
AC A0A158R999;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Integrin_alpha2 domain-containing protein {ECO:0000313|WBParaSite:TASK_0000689601-mRNA-1};
GN ORFNames=TASK_LOCUS6897 {ECO:0000313|EMBL:VDK37508.1};
OS Taenia asiatica (Asian tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000689601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TASK_0000689601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK37508.1, ECO:0000313|Proteomes:UP000282613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; UYRS01018548; VDK37508.1; -; Genomic_DNA.
DR STRING; 60517.A0A158R999; -.
DR WBParaSite; TASK_0000689601-mRNA-1; TASK_0000689601-mRNA-1; TASK_0000689601.
DR Proteomes; UP000046400; Unplaced.
DR Proteomes; UP000282613; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF133; INTEGRIN ALPHA-PS2; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000282613};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 31..1340
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5036506287"
FT TRANSMEM 1286..1308
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 349..387
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 470..531
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 554..616
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 782..854
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 1018..1246
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 390..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..953
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1340 AA; 148423 MW; E16D24F4B93750C1 CRC64;
MLQFHFALPL NFYLLLFFLF TFLLPLTTLA VDMGPKYSSD WLFPSLGARI YSTEKRGSNF
GYSVASYVAQ SQAFCLVGAP KAQNTYYFLG HDPVDIHSQQ DSLTSMFGNT TGLIYRLNLD
MDYPDCSKMP IADNNEDRRL YGTLEPGISQ WIGGLVAATS NGGDGLQLGC DPRYLYTPSP
LTASSKASSA SASLTGLEVQ NLGTGTCALY TGVSMQYTPI DACVSAEEGA CLSGFSGVLE
PGDEPGEAFT VLGMPGSYLT EGNVFFGHYQ GRRVLKQLRL KSTPQDLKHK GFNLGYAVGL
YKHPQWGNQD STSSFSRFTI LASSPMWVEN DYRGVVMLLT EALNLDSIQY IKDKWGHIGS
FFGYSIAAAD LNGDEIPEII VGSPYFSENQ RFTKPQKGPE TSPDMQADQA TQLDEDDNQE
NRYRPITPDV GRVYVFYGRP QEGIMGAGYM ENEEDLGQRG RGEYMHEPPV ILRGPRRSGG
RFGHMVLSMG DLDGDGTEDL AVSCPFCQDS HKSVDKGAVY VYLGRKDSKI KDEPDQVIYP
ADLPTKGVFA CESSFDDAPP LKRPFSAFGW SMASKSDVDG NMSPDLVVGD YESEQIVTLR
SRNLAWLEQP LWRLPERPTL DWSGPQNSPC ESSRCHYRVA LNLSLHAREA FFSSKRGVAL
RFRYRIDLDS RIKQENAKRL QSVKLGKSVV EDTVEIQLSN LEGYSVGFRR FQLFELIVEP
RWRQTAQQLW KPVVINVTIE MFSEDMDFIT TEGAKIPHWS LHPLKGEPTF LSQPMYFSNP
DCGYDDICVP DLNVEVYDTS EGFEFGGEGP STIYYKERVS ERNFTVAVRN LGENAYDTKV
RVHIPAHFAY IPDKNYACKI ESELTEMEEE DVEEKRDGGV VMGGSGARMG VNKSKIPITT
VVCSLPNPFL STSPRWEKIR FQLGTSGVFQ PPPGGTRSRS LESPNGSQAS GNATGAVVTT
PIWLPPRRLE IVAEVTSDNE NMRDRKVVAK FSYDLKLFAD IKLSSSSVGH TVFDRRNFSS
QFTERQRVHP ESIGPEFEQI FLVSNLGPSP MENIWVNLSV PLQTESGDFL VYLLDLIRTQ
NANGGSPLQI PVTPDVVSAD GQLRGTCYTP ESAINPLRLT AVDRKRSGGS STSAGRNSAR
SFLYRGRRDT ETAFETASES ASPVREARST VGADLLSEHV QQQKIVSCNR PLENLGSPVC
LHIPCKIDRL GRGDAVRIVF RGWVWADTLF RHKFSDIAIV TTATAQIPLY AFGIPVTGNF
TITGLTVSQN FVFEGIKMII TQTIPILPVI VGVVLGILLL IIIIIIMWRC GFFKRKRLTD
EAVAAASGAT ANGENGHKPI
//
