ID A0A158R9I2_TAEAS Unreviewed; 930 AA.
AC A0A158R9I2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN ORFNames=TASK_LOCUS7291 {ECO:0000313|EMBL:VDK38137.1};
OS Taenia asiatica (Asian tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000729001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TASK_0000729001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK38137.1, ECO:0000313|Proteomes:UP000282613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
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DR EMBL; UYRS01018598; VDK38137.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158R9I2; -.
DR STRING; 60517.A0A158R9I2; -.
DR WBParaSite; TASK_0000729001-mRNA-1; TASK_0000729001-mRNA-1; TASK_0000729001.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000046400; Unplaced.
DR Proteomes; UP000282613; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44395; -; 1.
DR PANTHER; PTHR44395:SF1; PROTEIN O-MANNOSYL-TRANSFERASE TMTC3; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF13432; TPR_16; 3.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 5.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000282613};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 113..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 278..348
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 476..509
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 510..543
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 593..626
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 627..660
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 724..757
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 930 AA; 105288 MW; E2B5A9ACB4A01822 CRC64;
MRKRNRPPSK EVQENVPPSS ISDYSLSTWH YPLLILLTLL VYSNSLSCGF VFDDASAVVD
NQDLRPYIQP WWVLFSNDFW GTPMVHESSH KSYRPLTVLT YRWNFALAGL KAWTYHLVNV
LLHTFVVYLF YWFSRRFLEP PGSLAAALLF ALHPVHVEAV TGVVGRAELL SAVFVFASLL
TYLNLIGVEE VPLLSEMCHL LTVSLLVILG TLCKEQCITV VGVCLAYDFV FYFINTFYAK
ILVGRMAWKA WRRVGLRFLV LLLTSGLFLL ARIQLMGSQL PHFTAFDNPA AHAPPLTRRL
THLYLVYVNL ALLFYPSGLC ADWTMGTIAL ITSLTDRRNI GSFAALAGLV GVAVRCASPW
TSPRQAYTLS MGMALLALPF LPASNLFFYV GFVVAERVLY VPSAGFCLIL GLGFQYLLQK
CRQCRQAGLF RLKALAYLLL AIVCSGFSLK TFYRNYDWKD EYSLFTSALK VNQRNAKLWN
NVGHALEGRL QFDEALLYFQ QAVRVQPDDM GARINVGRTL VQLGRLDEAE TVYYQAMEFF
PKPKKGKVYH TRVSPKDLTI FINLANLLSK NDSRLDEADA LLRRAISLRE DNVDAYQNRG
SILVRQQRFV EAEDMYRKAL RYKYTSAALH YNLGVVLLET NRTEEAYASF NRALRFDPHH
EQTLFALASS YSETTDPVLH EKAMNLIHRI LLLKICMRKI SSLSDFELPI GSFEDLAGRN
YEPVRVNFAL AILYTDAGQF AKAARHYQAV LEVDPTHRSS LFNLALMYHN ELNDSLAAVP
LLHRSLEVRL TASLISSQFA RMARSFLLSS PAGRTVVPTL NSFPDSRNFL SFQHHPDHFK
SYMLLGDIEL SVLKNATAAI KVFEKAITLS PNNLQARHNH CVALVEGTGD LEAGERCLRE
ATALADPADP TDVFVFRHLA LLQARRRRRT
//
