ID   A0A158RBG7_THECL        Unreviewed;      1390 AA.
AC   A0A158RBG7;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=G_PROTEIN_RECEP_F3_4 domain-containing protein {ECO:0000313|WBParaSite:TCLT_0000453801-mRNA-1};
GN   ORFNames=TCLT_LOCUS4527 {ECO:0000313|EMBL:VDN01650.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000453801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0000453801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN01650.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UYYF01004292; VDN01650.1; -; Genomic_DNA.
DR   STRING; 103827.A0A158RBG7; -.
DR   WBParaSite; TCLT_0000453801-mRNA-1; TCLT_0000453801-mRNA-1; TCLT_0000453801.
DR   OMA; VKIMEYE; -.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   CDD; cd13953; 7tm_classC_mGluR-like; 1.
DR   Gene3D; 3.40.50.2300; -; 4.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24060:SF172; CELF35-1; 1.
DR   PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 2.
DR   PRINTS; PR00248; GPCRMGR.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 2.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..1390
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5035044906"
FT   TRANSMEM        1017..1041
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1053..1073
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1085..1104
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1125..1151
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1171..1189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1201..1225
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1231..1249
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1047..1256
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
FT   REGION          1276..1297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1280..1297
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1390 AA;  157662 MW;  CDA57E68C85E5E9A CRC64;
     MQIIDLFFQA VLLILFNKCH GLNPLCNIYD PFRIQPDDNK YQIGATFPLH EKDCLKLRVE
     TVQDIVAVQW ALTHWNQNSK TSQMKTGLYA GDTCSKPKEA ISQTLKFLDS LNFYEPDECN
     TRNQNVRNLL GLILPKDALS AKSVASIFQT TPLPLLTYSY KAADVLAQMK FPYFATTAPT
     LDVFIDAFIR LMKNMNSNLV AIVSRNEDEI LVNYIVEKLR QKNIFVSELI NPKIAHFDQI
     IQESDSQIIF TPLSRSEIAK LLSGTSTGSD KTWVIIELDA NEQRSGEESS QSSINSDTQI
     IYLRQQQRDL PHFKNYFLRV LKNNYQSYSL LNSLMQQMYN CTVGGENKDN DCSKVDLQTM
     ALTYKQASTV ESVIRAVYAF TAVAIKLEAN PKISGKCKKP SVECTKLIME EIGSLIYEFD
     SNDPAELIGT NLHFYLESNT TLISNGIVIE GIEVINDEKM NPREVKIMEY ETGLKPRFAM
     TSPHRKPIHS ACAPYRPYCG QCSYIANIDQ KRFYLPDPRP HPLYITGLFN FHGGRSCQSY
     RNSDISLPLA FLHTMTTFSQ RYSEITLLQN LEIGAVLIDS CSSARKALET VVLTENHCFT
     IERGGHNEYS GYASSLYGRV AETLKGLFAS GDNLLISLDA DHDIAFNAFS AIPSKKHETL
     ALLLLLKKFS WEYISIVISN QESSLMSTYR LFEKLAMENG ICIAEVKIVN GEEVDSLSTA
     NVTILFTTAS DAATYFASKF RKELHYPHVH IVIGDAHDFY LHDPSNIARF VGTISLQPKD
     VIYDEFRTWL EEATPLSLTE EWYWEYVENR WQCALSEANR HFYDGKMCTG DELLDIPSLG
     RMTKSGYLAL GLERFLFALD AVYKQLCPEQ NGVCEAFYVK GREQISKILK KAHIDDDFDI
     YEFLPDGQGS YSYKNIGNYS SKSGFKFSES YRYFDVLGNQ ISDEVSHLRI KSQCISSSCK
     CFTGMKSMQM SSSVFDESAA YAGSYIRRVP TNDAFHHIRS LSILDRLTAG RWRLQTWNYA
     LAAIITVMVI GAIGVLLLAI IKLYLRVIKG NQSLGLSLLI GVIILYITGY GFVFEATDIV
     CRFRIILHPV GYAFCFAVII AKATQLKNAE SMGFSDDIHI SYWNYWLLLF FITGVQIALS
     WLMIDFASVV IVEDEQPHLV CRYGNDEFLL SQSYVIMLLL LALYISSTSK NIKRNYKETK
     WLFISSLSCA VLWIMWITAF VLVPLPYKDT VIVVELLLCA SVLLGFVFGP KIYIMLSYES
     VVVEMHPQHT MKDFVSDNED SKQTCSPSSS VESRKSRTQS TCSVTNCKNL SASKRPDADD
     DQIPIFRTVM RKKTHLRRSQ SADRQNLNRI IQQPSLPSKV IKCQYRKEGN GNYFPHTTHA
     SRMSDIAKIC
//