ID A0A158RBN8_THECL Unreviewed; 1830 AA.
AC A0A158RBN8;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Condensin complex subunit 1 {ECO:0000313|WBParaSite:TCLT_0000512901-mRNA-1};
GN ORFNames=TCLT_LOCUS5118 {ECO:0000313|EMBL:VDN02322.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000512901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000512901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN02322.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Ntn-hydrolase family.
CC {ECO:0000256|ARBA:ARBA00010872}.
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DR EMBL; UYYF01004321; VDN02322.1; -; Genomic_DNA.
DR STRING; 103827.A0A158RBN8; -.
DR WBParaSite; TCLT_0000512901-mRNA-1; TCLT_0000512901-mRNA-1; TCLT_0000512901.
DR OMA; DVIAKLW; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004298; F:threonine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007076; P:mitotic chromosome condensation; IEA:InterPro.
DR CDD; cd04514; Taspase1_like; 1.
DR Gene3D; 3.60.20.30; (Glycosyl)asparaginase; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026971; CND1/NCAPD3.
DR InterPro; IPR032682; Cnd1_C.
DR InterPro; IPR024324; Condensin_cplx_su1_N.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR000246; Peptidase_T2.
DR InterPro; IPR037464; Taspase1.
DR PANTHER; PTHR14222; CONDENSIN; 1.
DR PANTHER; PTHR14222:SF2; CONDENSIN COMPLEX SUBUNIT 1; 1.
DR Pfam; PF01112; Asparaginase_2; 1.
DR Pfam; PF12717; Cnd1; 1.
DR Pfam; PF12922; Cnd1_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776}.
FT DOMAIN 422..568
FT /note="Condensin complex subunit 1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12922"
FT DOMAIN 1582..1726
FT /note="Condensin complex subunit 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12717"
FT ACT_SITE 158
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR600246-1"
FT SITE 157..158
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR600246-3"
SQ SEQUENCE 1830 AA; 206473 MW; 343DD5BA71711ED2 CRC64;
MGAFVAAHAG AGTHAYKTED ICWNAVLKCN GNIVEAVKIL ENDAKTNCGY GSNLSLNKHV
ECEACFASTD GHVFGAVGAV SRVRNPIEVA AMVAKEQLVA NSKFVLPAVL VGEGAEQWAE
KRGVKLCDPA SLISRRAEKD WKQAQKVVQS WGDKTMDTVG AVSYDNGECS AACSSGGIIL
KHEGRLGHVL QYGGAVCADK RNARSVAVTL SGCGEYIART LLARNIAECL LNGDNDDDFI
LTKVKNVFYS AFLNSPYLAN RNKKHVLAGG LLLFVDNEKS SAELVSFHNT QELTFAFGNR
TVVKSRSRSV SGDFINCKNV LPRFALRENK VMQNLDKFVI PSRDDDLLEG SFDFYTISIR
PELDEIISKV FQFRHDIDSG RWARIIDRFD HLFFTIKPFS EGEPWRLRSQ LISFLNSGLK
LTLDSIEELL PMLTSEAETE LAQDLFTERE LHAKALLMYI YLLCRLAVLF EKESSNRPIE
VASTKKGRKA MPEKADDQYM TQWISDRANT LKLLHRTFSL NSLDAQGRKR STAIRFLWHP
SIVPSELLRI SKDLAFKFLE NPELSKVSGR DWLQAIFGYL KVICIDYNEA TKIGIKLVSL
MKRLDYLSLS SLTQSPFVDA IESVSYYGDM DILFQAMLSA LSRLSKSDFA RNDVSARPFT
LFIVSLAEKK PHLLNKHIVN IASFLSDDPA SLRCAVLTAF VEIVMVVYKG NLPEGNFRRS
RDRLLLHLQD HVVDVNAVVR SRALQLWTRL ARASQIPIVF MSGGLIRDAG GRLIDKSVSV
RRNAAAFLSA VLEYNPFGAS LNADDLADTI ARFEAERLEM RTTNPEKEGI KKACVEWASM
KENLNRWIGK YVKQRLKNKQ TVDVTEKVIE NSAVDHNENE NATSLYCYEI MFGIFLCTNF
FSRSKNIAGE VGNIYEEVTD VSGTTNTVDD CIIDEDVTLE ELITKIVLAL ENLETRRAAI
KVLVRAGLDG RIPTVDKNGT ADSIARECYE SLQVYYFDEH KKMQLDDDEE VLELEDRIGD
YQKIMEELDN KNAIMFSLEI ETCIKLGLRS IMNGQANELA EIIHFIVEAN KFSIRGSEAG
VRELFKIVWR RDNAVKEIII NAARDLFISS NEDRDVSARK SAENLIKIIL GVGEEDRVSV
EEVLCLMARE KRWDIDLLDV LSAIVFETQG ASRIAALRLF SIVCRANKEF MRERLNFFIE
LTQRDGFFDN DDGTLAAEFF NAIAMLGSIS NTNDVSTLHE APFRLTETHR ILQCVHAVLV
QNVANVSYNW LPMMHKAVNT IFYVAARPSL CCRLIASGLM HEAKRSLAFF FLKKREIEQI
ETVNFENPPN SADIDEFGDL LVRAKEWSQD SEIENEQPIK SQTFVAVEEE NLLSMKAEAL
DILKKEKDQC FIVWEIVAER VCAFAGEVAL KTLVHTDVSF VAEMKRKNEV LHSFRTTIND
DNRDKLETAK FFEDFPSSRV PTTLEIKSIE RQGFFEVSEQ EEGDRLGLTG DLFSGISEDE
RVSERAQQIS ENAVSRKGSL LYRLSKFLIA VVKSEKNTCS ESLRSTAILA LAKFMLLSMK
TCTRYMPLFL DYFKHSPSSE CRSNLMVAVG DLCFRFPNII EKYSEHLYHG ISDKDDYVRQ
TCIIVLSYLM LNDMVKVRGT VADLALCVND DNVNVGQLAK FFFSELSKKG NILYNLMPDM
ISRLSSRESV TTNSFITIMK LLLGFIKKDK QSDSLMEKLI QRMQGVITKD GVVDTRLAEC
LSYCISCLSL TDKSFRFMAE SLPSYSNLLV LESVYLNLQS AVLHFKKYSV RNPELKGEVD
EFLEALTKVH GDKLEHEGIV NRGIVHRVRI
//
