ID A0A158RBS0_THECL Unreviewed; 796 AA.
AC A0A158RBS0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Rad4 domain-containing protein {ECO:0000313|WBParaSite:TCLT_0000542201-mRNA-1};
GN ORFNames=TCLT_LOCUS5411 {ECO:0000313|EMBL:VDN02655.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000542201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000542201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN02655.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; UYYF01004338; VDN02655.1; -; Genomic_DNA.
DR STRING; 103827.A0A158RBS0; -.
DR WBParaSite; TCLT_0000542201-mRNA-1; TCLT_0000542201-mRNA-1; TCLT_0000542201.
DR OMA; FQAKHLG; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776}.
FT DOMAIN 507..559
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 561..616
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 623..697
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..136
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 93492 MW; DFF1403983A60EEE CRC64;
MTSVVPRRSS RRKRESEAPS DQNVVEKIDS KRVNVLKQGN VSKNTEVKDN ARNYVARVSG
RLCRNAKKKK EIMLENDLEP IIKKSRNGTD AGSTEDLKPN RQRQRNQSSK RKISDGEETY
QDESSDSSIS DDEWEDVDLT DQHNYEPSGM NDNVEVTISA SRSKETEESK WAKFIRQQVN
RKIRERQINC HKMHLLCYIA HLRVWIRALV RDEALASLCL SLIPEGYLAA AKHTFDVATA
ERFLKWFRSA FQRTYQSYVP KTDYWDYHVR RLKKLIEERV YENDKDLSSL LFLCLVSLNL
PARLCLSCQP VTQKPSMNML RSKYTEIFVE QNVDNSDSCE IWEMKLNEVL NKIEVKSDED
YCEKHNSKNR QRSKNEKKKK PNKNGDTISS KILSSGRQKC GQERNYWVEY WDRDDSKWIC
MDPWFGSVDM PESLEMSTTA PMHYVLCIDD DLGMRDVTAR YASKFLSADV RRLRVEPSWW
TNTLKLYRSK NRRRERIEDI AIHNELLSKP KPATIAEYKN HPLYVLKKDI LKYEAIYPEN
QASIGQIRGI DIYPRSSVFH LDTSLNWMKQ ARVVKKEEKP YKVVKGRVNH RVAPELREPR
SLELYGYWQT EPYVPPKVVD ERIPRNEFGN IYVYKSSMVP EECVHVRLDG LVTIARKLDI
DCVPAVVGWD FHKGGNHPIV DGCVVLKKHE NMLRKVWKEF HQKKQIAFEQ KRKERALKNW
RRLTKGMLTM RKVRAKFLRM DRRSMRLAFF SGDVILQEID EKLEDQVLTP APDDTILSWP
HTIFNLPEST VNRGRR
//
