ID A0A158RBT3_THECL Unreviewed; 1177 AA.
AC A0A158RBT3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN ORFNames=TCLT_LOCUS5509 {ECO:0000313|EMBL:VDN02761.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000552001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000552001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN02761.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR EMBL; UYYF01004343; VDN02761.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158RBT3; -.
DR STRING; 103827.A0A158RBT3; -.
DR WBParaSite; TCLT_0000552001-mRNA-1; TCLT_0000552001-mRNA-1; TCLT_0000552001.
DR OMA; WDTYIEM; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF36; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 500..521
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 530..548
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 585..610
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 617..635
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 715..732
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 752..772
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 800..819
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 839..856
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 900..922
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 928..950
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 971..989
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 143..421
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 471..978
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1148..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1177 AA; 132015 MW; 8EC2F0766C7278FA CRC64;
MSDTEDDSND KIEFPTSSSP AVHATLEPTV NIVPPTVSDV TPRAPLAQFE QAEQQVIKPR
GCIWDTYIEM SDVAERKRRM SRRLDSIDRT QHLASLAPGA RVMFLLKEQS DLPPLFTEMG
ELTRSGTVEE WRETARWVKF EEDVEEGGNR WSKPHVATLS LHALFQLRSC LMNGAIIMDS
KAKEFSELIE EILEQLVRSK QLEETLVDEV RNVLSKRHTH QYEQARGAGN GNGISQGGFL
SAVRSISDIG KTFSHGRNLG KLPEETVNEG NETTSKSQHL KLPEVGPIPK DVSCEGSHVD
LRGNLHFLKK LPSKAEASNV LVGEVDFLSR YISAFVRLEN ATSFGDLTEV PVPTRFFFVL
LGPTGNVAQY REIGRAIATL MSDEIFHDVA YKARSRDDLL DGVDEFLDQV TVLPPGEWDP
NIRIEPPTKL PSQDKRKQGD ELLLTKIPAP KKEMEEEDSH ASDPALKRTG RLFGGLIMDI
KRKIPWYLSD FTDSLNLQCV ATFCFMYFAL LAPIVTFGGL LEEATHQRMA AMENLFGGAI
CGVIYHLFSG QPLTIIGSTG PVLVFETIVF DLCTSFNLDY LSFRFWIHVW TAFILLLMVI
TDASALVSYI TRFTEESFAT LIAVIFIYEA VMKLVKIRTL LDIVQYNRTD PLATCSCIYT
GDHLTKALNV IEKNNWKDIA HNKTFIDYSR VGLDRCRSLY GTLEGDGCFV LYDKLLMSLV
LMLGTLTLAL ALKKLRNSRY FSSRVRQVLS DFAVMIAIVT MTFIDICVGI NTPKLNVPST
FRPTWEGRGW FVPPFNGNPF WTAFAASAPA VLACILIFMD QQITTVIVNR KENKLKKGYG
YHLDLGVLAC LILVVGVLGL PIYVAATVLS INHVNSLKLE SESRAPGEVA QFIGVREQRV
TGIVTFIFIG CSVLMTGILS YIPMPVLYGV FLYMGIAALG GIQLFDRILL LFMPMKHQPD
AIYIRHVPIS VIHKFTFCQV ACLAVLWVVK SIKQTSIAFP IMLVVMVAVR KIMENFFSEK
DLRYLDDKMP DFHLRKKEDM KRKGNIAKEF DIDLEENQGT IHAVKTEAHL HIPTTGGEII
KIPLAAIQES SHNIHNLNIS NEVNKTGMWK HISSERQHLS LQNKIAGKVK AAEEDDEDED
AIMIRVIKPT APSNLNTQSN SEQTPLLRDK QKSETKV
//
