ID   A0A158RC39_THECL        Unreviewed;       837 AA.
AC   A0A158RC39;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=FERM and PDZ domain-containing protein 2 {ECO:0000313|WBParaSite:TCLT_0000636701-mRNA-1};
GN   ORFNames=TCLT_LOCUS6356 {ECO:0000313|EMBL:VDN03700.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000636701-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0000636701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN03700.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UYYF01004409; VDN03700.1; -; Genomic_DNA.
DR   STRING; 103827.A0A158RC39; -.
DR   WBParaSite; TCLT_0000636701-mRNA-1; TCLT_0000636701-mRNA-1; TCLT_0000636701.
DR   OMA; HRFMIKM; -.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd17101; FERM_F1_PTPN13_like; 1.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR46900:SF2; -; 1.
DR   PANTHER; PTHR46900; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS50106; PDZ; 3.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776}.
FT   DOMAIN          47..352
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   DOMAIN          427..510
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          654..739
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          753..835
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          531..556
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   837 AA;  94595 MW;  34B39BFF195FCB71 CRC64;
     MSIRLMHFLD QQFVRRNSLL PDRISGRKSS RHLKRKKKVT LHRVEHTDVT VELLSGRHVE
     VSCRSDAVAS EIADVVMRHL NFTENSFFGL TVLRDGEHFF LDGHQRLEKF APPGWKNARQ
     RGLSKRSYML FLRFRYYPAS LAFIRTEVVL HELYLQLRRD ILDDRILPKR ELLYTLAALA
     MQSEYSDQPN AKISDYFDAQ YYIPKRYMDS RDKKAVIQDL VEKHGKYRGM KQIDLTQRLS
     DYGAHLYRVF TSKPSINLGN IPFGDPQTGV AQWIGIMARG IVIFEEESDG RHAQTEYLWQ
     NTQTLQFDKK RFVIVSEIHE PSTNVFYTNH YSKSSYFVRF AASQHRFMIK MRQWNHTLRH
     DSPFQFHKVP DVGADTDLIK EVTVLFYLIV TKILVALYLL FVQKGDNYDD EISVDPLSEN
     VDGYVLEISL KKDPSTGLGL TLVDGNLNGV KGVYVKSVSE GGAGREGVMN VGDRLVSVND
     VSLVGKDRHA TVDLVKQCSD IVHLKILRLE ALSSSLVTGI ANKGVLNDQK KDNHSFSVSS
     KGTRSRTPPP SRKHPHVLKK RTRAISDFGA VGDTLPDLNS EDLLANLKKS LSNERVEQRM
     DYDMTVASMY KFEDVDDDVT EHSVQHSAIV PYCVFKSHES GWLGSEKSDV DQQKIILHRN
     ELGSLGFQIA SSAGIVYVKQ ITAEPALSCP NISVGDKIIM VLALYFVNHK RVENMAHQDV
     VDLIRKSGDK VAICLEHIDK EMIALDDDEQ TIRVVLEKST TGSLGLSLAK KTGYDGIYIR
     MISSGSAADI DGTLHIGDRI WKVNGDSVSS HTPGAIVDLL KAASNPVEIV VKRTINK
//