ID   A0A158RC92_THECL        Unreviewed;       870 AA.
AC   A0A158RC92;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE            EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN   ORFNames=TCLT_LOCUS6768 {ECO:0000313|EMBL:VDN04157.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000677901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0000677901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN04157.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC         and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC         residue protein attached to proteins as an intracellular targeting
CC         signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm,
CC       perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC       {ECO:0000256|ARBA:ARBA00009085}.
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DR   EMBL; UYYF01004443; VDN04157.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A158RC92; -.
DR   STRING; 103827.A0A158RC92; -.
DR   WBParaSite; TCLT_0000677901-mRNA-1; TCLT_0000677901-mRNA-1; TCLT_0000677901.
DR   OMA; CEKMSNW; -.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR036859; CAP-Gly_dom_sf.
DR   InterPro; IPR000938; CAP-Gly_domain.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR028889; USP_dom.
DR   PANTHER; PTHR11830; 40S RIBOSOMAL PROTEIN S3A; 1.
DR   PANTHER; PTHR11830:SF3; CYLINDROMATOSIS, ISOFORM D; 1.
DR   Pfam; PF01302; CAP_GLY; 1.
DR   Pfam; PF00443; UCH; 1.
DR   SMART; SM01052; CAP_GLY; 1.
DR   SUPFAM; SSF74924; Cap-Gly domain; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          484..856
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
SQ   SEQUENCE   870 AA;  97601 MW;  015AB1E963CC3A94 CRC64;
     MDGSFNGRRL FEAPPHGAVL VSGNRLRNPR NVSILDADLK FSAHGFSSSP VYYRDNFSSL
     RKGQHGALNI PITQPACNES ATSPIIHLES NIGYNRNSSL NRPLIREIPI RIVQATSAGK
     PQSCTLPPNQ SSSSVLRNGG FPICCADEEI SSHPDINGSD QLEKSENCAK VPSLKQPIFR
     AKESIEEPSR NSWNEKRTTS LIAMETVRLK LGNGKLVEGD RVVWFDALGM PHRGTVQWIG
     YLRGHTNVYV GVDFDEAIGG GTGYFEGLEL FCCAPNHAGL LPISVCMKEE DMGDEDYSKP
     AITSLKLRPS SAEDQNHSSR LPLMSGNLDL APVQREPLID NEERVILSDA QFTVGSCVEV
     FYRNERRYGV VKWIDSGSNL IHSNCLVAVD IEGDVPEDWE AISKTLAEDN LEAVFASSSL
     ESITLVPYCA LRSDNRFSAC SAPEIDNCEA KTIVTTNFGS LDSGIEVRPC FPTKNIESLV
     GRMKGIQGFR NSCYLDATLY AMFAQCTAFD RILESRCETE ADSIHTEVTD ILKTEIVYPL
     RRFHFIRADH VLKLRCLLER LLPEMKGLTT GEKDPEELLN ALFTTVLRVE PFLVIRNMTD
     NKTNAAYICP LITEDLWSEE QRRLISVQTL LERSFFASNI QFAHAPKILI LQLPRYGQQK
     VFDKIFPPQE VDITHLIYNS KRPCINCGRL ADLMCPECFL TQEVFIAEVT YCGICYERTH
     SGLDHQPQEL LVDTSNLFSS SNSLSLSRRM QVPQIKLQLA SVLCIETSHY VAFVRALFAN
     KWTFFDSMAD RVGLSDGYNV PQVKLCEKMS NWLSDTGWYK INESVIREGH LPNDVLNDPD
     LMRLLSDCYI CFYTDEENKN GSLSLSRFLF
//