ID   A0A158RE04_HYDTA        Unreviewed;       425 AA.
AC   A0A158RE04;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=DHHA2 domain-containing protein {ECO:0000313|WBParaSite:TTAC_0000641501-mRNA-1};
GN   ORFNames=TTAC_LOCUS6400 {ECO:0000313|EMBL:VDM30601.1};
OS   Hydatigena taeniaeformis (Feline tapeworm) (Taenia taeniaeformis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Hydatigera.
OX   NCBI_TaxID=6205 {ECO:0000313|Proteomes:UP000046396, ECO:0000313|WBParaSite:TTAC_0000641501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TTAC_0000641501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDM30601.1, ECO:0000313|Proteomes:UP000274429}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the PPase class C family. Prune subfamily.
CC       {ECO:0000256|ARBA:ARBA00010331}.
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DR   EMBL; UYWX01020301; VDM30601.1; -; Genomic_DNA.
DR   STRING; 6205.A0A158RE04; -.
DR   WBParaSite; TTAC_0000641501-mRNA-1; TTAC_0000641501-mRNA-1; TTAC_0000641501.
DR   Proteomes; UP000046396; Unplaced.
DR   Proteomes; UP000274429; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016462; F:pyrophosphatase activity; IEA:InterPro.
DR   Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR   Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 1.
DR   InterPro; IPR001667; DDH_dom.
DR   InterPro; IPR038763; DHH_sf.
DR   InterPro; IPR004097; DHHA2.
DR   InterPro; IPR038222; DHHA2_dom_sf.
DR   PANTHER; PTHR12112; BNIP - RELATED; 1.
DR   PANTHER; PTHR12112:SF39; EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN); 1.
DR   Pfam; PF01368; DHH; 1.
DR   Pfam; PF02833; DHHA2; 1.
DR   SUPFAM; SSF64182; DHH phosphoesterases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274429}.
FT   DOMAIN          22..185
FT                   /note="DDH"
FT                   /evidence="ECO:0000259|Pfam:PF01368"
FT   DOMAIN          234..417
FT                   /note="DHHA2"
FT                   /evidence="ECO:0000259|Pfam:PF02833"
SQ   SEQUENCE   425 AA;  47755 MW;  264E733ED8958A9A CRC64;
     MLSAFLKYLH SLPKSCPTFK FVIVTGNESC DLDSIACATC YAYIKSKEDP DKEVIYIPYC
     NIPESDIDLR TEATFWLRNC QIDKKDLFYA GSLNWLLGPE YAKELSLILV DHFQKEPSNA
     FVFCPVSEII DHHPLLPDYR KPGTCQFFLV EKVGSCSSLL VHELFNRISP ALIPPELCRL
     LYGAILIDTD GLSERAVEIQ KATQKDVEAV RKLETFAGMA LHTVGTTRTS IYAAILEAKF
     CIDGLSLWDL LRRDCKKVIA DSDSHTDIVC STITGMDFKE LLDRDDFNQE AARFCEEQNA
     RVLVCVTVGL ASLPSRDHCL DQPSSMPLSK KFHRGVVVTA PVRYRNLMNS VKDAIFILSF
     NIMLWAHLLA NAKDFLVGYP LGGELSHHSS VGEVETGVYV ARITDEAVTR KQLIPLLIDF
     LRSQK
//