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Entry: A0A160DXS3_9GAMM
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ID   A0A160DXS3_9GAMM        Unreviewed;       345 AA.
AC   A0A160DXS3;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   08-MAY-2019, entry version 17.
DE   RecName: Full=S-adenosylmethionine:tRNA ribosyltransferase-isomerase {ECO:0000256|HAMAP-Rule:MF_00113, ECO:0000256|SAAS:SAAS00958187};
DE            EC=2.4.99.17 {ECO:0000256|HAMAP-Rule:MF_00113, ECO:0000256|SAAS:SAAS00958171};
DE   AltName: Full=Queuosine biosynthesis protein QueA {ECO:0000256|HAMAP-Rule:MF_00113};
GN   Name=queA {ECO:0000256|HAMAP-Rule:MF_00113};
GN   ORFNames=I596_3190 {ECO:0000313|EMBL:ANB19180.1};
OS   Dokdonella koreensis DS-123.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Rhodanobacteraceae; Dokdonella.
OX   NCBI_TaxID=1300342 {ECO:0000313|EMBL:ANB19180.1, ECO:0000313|Proteomes:UP000076830};
RN   [1] {ECO:0000313|EMBL:ANB19180.1, ECO:0000313|Proteomes:UP000076830}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DS-123 {ECO:0000313|EMBL:ANB19180.1,
RC   ECO:0000313|Proteomes:UP000076830};
RA   Kim J.F., Lee H., Kwak M.-J.;
RT   "Complete genome sequence of Dokdonella koreensis DS-123T.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transfers and isomerizes the ribose moiety from AdoMet
CC       to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give
CC       epoxyqueuosine (oQ-tRNA). {ECO:0000256|HAMAP-Rule:MF_00113,
CC       ECO:0000256|SAAS:SAAS00958175}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-
CC         L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-
CC         methionine; Xref=Rhea:RHEA:32155, Rhea:RHEA-COMP:10342,
CC         Rhea:RHEA-COMP:10346, ChEBI:CHEBI:15378, ChEBI:CHEBI:16708,
CC         ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:82833,
CC         ChEBI:CHEBI:82834; EC=2.4.99.17; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00113, ECO:0000256|SAAS:SAAS01116098};
CC   -!- PATHWAY: tRNA modification; tRNA-queuosine biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00113, ECO:0000256|SAAS:SAAS00958180}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00113,
CC       ECO:0000256|SAAS:SAAS00958162}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00113,
CC       ECO:0000256|SAAS:SAAS00958183}.
CC   -!- SIMILARITY: Belongs to the QueA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00113, ECO:0000256|SAAS:SAAS00958161}.
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DR   EMBL; CP015249; ANB19180.1; -; Genomic_DNA.
DR   RefSeq; WP_067649678.1; NZ_CP015249.1.
DR   EnsemblBacteria; ANB19180; ANB19180; I596_3190.
DR   KEGG; dko:I596_3190; -.
DR   PATRIC; fig|1300342.3.peg.3117; -.
DR   KO; K07568; -.
DR   OrthoDB; 368001at2; -.
DR   BioCyc; GCF_001632775:G1EST-3015-MONOMER; -.
DR   UniPathway; UPA00392; -.
DR   Proteomes; UP000076830; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008616; P:queuosine biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.10.240; -; 1.
DR   Gene3D; 3.40.1780.10; -; 1.
DR   HAMAP; MF_00113; QueA; 1.
DR   InterPro; IPR003699; QueA.
DR   InterPro; IPR042118; QueA_dom1.
DR   InterPro; IPR042119; QueA_dom2.
DR   InterPro; IPR036100; QueA_sf.
DR   PANTHER; PTHR30307; PTHR30307; 1.
DR   Pfam; PF02547; Queuosine_synth; 1.
DR   SUPFAM; SSF111337; SSF111337; 1.
DR   TIGRFAMs; TIGR00113; queA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000076830};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00113,
KW   ECO:0000256|SAAS:SAAS00958179};
KW   Isomerase {ECO:0000313|EMBL:ANB19180.1};
KW   Queuosine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00113,
KW   ECO:0000256|SAAS:SAAS00958170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076830};
KW   S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_00113,
KW   ECO:0000256|SAAS:SAAS00958172};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00113,
KW   ECO:0000256|SAAS:SAAS00958166, ECO:0000313|EMBL:ANB19180.1}.
SQ   SEQUENCE   345 AA;  38016 MW;  1C3B98C0C3B48C17 CRC64;
     MKKSDFHFDL PPELIAQVPL AERSASRLLV LDAAARRFED RALRDLPDLL APGDLLVFND
     TRVVPARLFG RKETGGAAEI LIERLTGAHE ATAQIGVSKK PREGTAIVLA DGTVVRVLGR
     DGEFFRLRFE TTEPLEKLLL RLGRLPLPPY IARDPDAADA ERYQTVFARE PGAVAAPTAG
     LHFDAPLLAA LERRGVAVGQ VTLHVGAGTF QPMRAERLDQ HVMHREWLNV GAGLVEKIRH
     TRERGGRVVA VGTTVVRALE TATRDGVLGP YAGETQIFIF PGYRITSVDA LLTNFHLPES
     TLLMLVSALA GRELILEAYR HAVEQRYRFF SYGDAMLILP DRGQP
//
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