ID A0A160FU28_9BURK Unreviewed; 1062 AA.
AC A0A160FU28;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN ORFNames=AYM40_30260 {ECO:0000313|EMBL:ANB76494.1};
OS Paraburkholderia phytofirmans OLGA172.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=1417228 {ECO:0000313|EMBL:ANB76494.1, ECO:0000313|Proteomes:UP000076852};
RN [1] {ECO:0000313|EMBL:ANB76494.1, ECO:0000313|Proteomes:UP000076852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OLGA172 {ECO:0000313|EMBL:ANB76494.1,
RC ECO:0000313|Proteomes:UP000076852};
RX PubMed=27063562; DOI=10.1016/j.gene.2016.04.018;
RA Ricker N., Shen S.Y., Goordial J., Jin S., Fulthorpe R.R.;
RT "PacBio SMRT assembly of a complex multi-replicon genome reveals
RT chlorocatechol degradative operon in a region of genome plasticity.";
RL Gene 586:239-247(2016).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU364070}.
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DR EMBL; CP014579; ANB76494.1; -; Genomic_DNA.
DR RefSeq; WP_063499717.1; NZ_CP014579.1.
DR AlphaFoldDB; A0A160FU28; -.
DR STRING; 1804984.AYM40_30260; -.
DR KEGG; buz:AYM40_30260; -.
DR Proteomes; UP000076852; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF11; EFFLUX PUMP MEMBRANE TRANSPORTER; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Reference proteome {ECO:0000313|Proteomes:UP000076852};
KW Transmembrane {ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|RuleBase:RU364070};
KW Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 395..419
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 472..499
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 881..900
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 907..927
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 933..956
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 977..998
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 1010..1036
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT DOMAIN 368..497
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1062 AA; 114952 MW; 7950A6BA5D660A26 CRC64;
MNISRFFIDR PIFAAVLSVL ILLGGVISIF KLPISEYPEI VPPSVVVKAS YPGANPKVIA
ASVAAPLEEQ INGVEDMLYM ESQATSDGNL SIRITFKLGT NPNLAQQLVE NRVSQALPRL
PEDVQRLGVT TIKSSPTLTM VVHLISPNSR YNLIYLRNYG LINVRDRLQR IPGVGEVQLK
GAGDYSMRIW LDPQKVAQRN MAATDVVNAI REQNVQVAAG QIGASPATPD ATVQLNVNAR
GRLQTEEDFR NIVLKTGKDG AVTHLRDVAR VELSAAEYAD RSLLNNKPAV AMWVFQQPGA
NSLDISANVR KTMEELKADF PPGVEYRIVY DPTQFVKASI HAVIHTLFEA IILVVIVVVI
FLQTWRASVI PLIAVPVSII GTFSLMLAFG FSINALSLFG MVLAIGIVVD DAIVVVENVE
RNIETGMSVK DATYKAMEEV SGPIVAIALT LVAVFVPLAF MSGLTGQFYK QFAVTIAIST
VISAFNSLTL SPALAALMLK GHEEPKDWLT RGMETVFGGF FRVFNRTFKS GSEKYGGSVG
IVVLHKGPML GLYAVLIGLT LLMGKMVPGG FVPAQDKQYL VAFAQLPNGA SLDRTEQVVR
QMSEIAMKQP GVQDAVEHPG MSINGFVHSS SAAVIFICLS DFDKRTTKET SGPAITEALN
KKYAAIKEAY IAVFPPPPVL GLGTVGGFKL QLEDRAALGY SALNDAAQKF LKVAAQTPEL
GPAFSSYQIN VPQINVDIDR TRAKQLGVAV TDIFSTLQIY LGSFYVNDFN KFGRVYQVRV
QADAPFRSHT GDLGFLKTRN ADGDMVPLSS VVTVTPTYGP DDVVRYNAYT AADINSGPSL
GFSNNEAQKA IDRVAAQTLP NGIKYEWTDL AYQQILAGNS AVYVFPISVL LVFLVLAALY
ESLSLPLAVI MIVPMSILAA LTGVWLTDGD NNIFTQIGLM VLVGLSAKNA ILIVEFAREL
EMQGRTIVEA AVEASRLRLR PILMTSIAFI MGVIPLVVSE GAGSEMRHAM GIAVFSGMLG
MTVFGLMLIP VFYVLLRKLA GGEVIVDRHG KRPTVRGIDA SE
//
