ID   A0A160P399_STRLU        Unreviewed;       663 AA.
AC   A0A160P399;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=SLA_5167 {ECO:0000313|EMBL:BAU86049.1};
OS   Streptomyces laurentii.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=39478 {ECO:0000313|EMBL:BAU86049.1, ECO:0000313|Proteomes:UP000217676};
RN   [1] {ECO:0000313|EMBL:BAU86049.1, ECO:0000313|Proteomes:UP000217676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31255 {ECO:0000313|EMBL:BAU86049.1,
RC   ECO:0000313|Proteomes:UP000217676};
RA   Doi K., Fujino Y., Nagayoshi Y., Ohshima T., Ogata S.;
RT   "Complete Genome Sequence of Thiostrepton-Producing Streptomyces laurentii
RT   ATCC 31255.";
RL   Genome Announc. 4:e00360-16(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; AP017424; BAU86049.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A160P399; -.
DR   REBASE; 144636; M2.Sla31255ORF5166P.
DR   KEGG; slau:SLA_5167; -.
DR   Proteomes; UP000217676; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 1.20.1260.30; -; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR022749; D12N6_MeTrfase_N.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR038333; T1MK-like_N_sf.
DR   PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR   PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR   Pfam; PF12161; HsdM_N; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:BAU86049.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000217676};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:BAU86049.1}.
FT   DOMAIN          9..141
FT                   /note="N6 adenine-specific DNA methyltransferase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12161"
FT   DOMAIN          154..457
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   663 AA;  74318 MW;  AC75B8A079C61C21 CRC64;
     MNSSKHTELA NHAWSVADLL RGDYKQSDYG KVILPFTVLR RLECVLEPTR DKVAETVQRF
     EGQDIDTDHF LRRASGHSFY NTSDLTLKKI VGDPQSAERN LQIYVSSFSA NAREVLDKYE
     FAQQIKRLDD ADLLYKVIGK FTDLDLRPEI VPNHNMGYIF EELIRRFAEQ SNETAGEHFT
     PREVIKLMVN LLIEPDGDAL TIPGVVRTVM DPACGTGGML SAAEEFIRKH NPEATVEVYG
     QELNPESWAI CRSDLMIKGQ DPENIAFGNS FSDPGHGREK FDFLLANPPF GVEWKKVKEA
     VEYEHKHLGE AGRFAAGLPR INDGSLLFLQ HMISMMKPVD TKGGGGSRVA IVFNGSPLFT
     GAAGSGESEI RRWILENDWL EGIVALPDQL FYNTGISTYF WILTNRKSPD HKGKVILLDA
     RDQFQKMRKS LGDKRKELSK QHIAEITRLY AEAVQVAADP EHPQHAKVKV FDNKAFGYQR
     ITVERPLKLR FEVTEETLTA LAAAKPVQKL ADAEAFVGAV RTLLGSSWTT KSDALVALKD
     AVVAAGLLWP SGAPFAKAVR EVVGVRDPEG EVQKIKGESE PDAELRDYEN VPLGEDVEEY
     LKREVLPHVP DAWIDHTKAK IGYELPVTRH FYSYEPPRPL TEIDAELKAL EAEIQVLLGE
     VTK
//