ID A0A161CB96_9ADEN Unreviewed; 920 AA.
AC A0A161CB96;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Hexon protein {ECO:0000256|ARBA:ARBA00019716, ECO:0000256|RuleBase:RU361265};
DE Short=CP-H {ECO:0000256|RuleBase:RU361265};
DE AltName: Full=Protein II {ECO:0000256|ARBA:ARBA00032254, ECO:0000256|RuleBase:RU361265};
GN ORFNames=CSPAdV-2_gp11 {ECO:0000313|EMBL:ALB78146.1};
OS Chinstrap penguin adenovirus 2.
OC Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC Rowavirales; Adenoviridae; Siadenovirus; Penguin siadenovirus A.
OX NCBI_TaxID=1434088 {ECO:0000313|EMBL:ALB78146.1, ECO:0000313|Proteomes:UP000150550};
RN [1] {ECO:0000313|EMBL:ALB78146.1, ECO:0000313|Proteomes:UP000150550}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CSPAdV_2 {ECO:0000313|EMBL:ALB78146.1};
RA Lee S.-Y., Song J.-W.;
RT "Analysis of complete genome sequence of novel adenoviruses in Antarctic
RT penguin.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Major capsid protein that self-associates to form 240 hexon
CC trimers, each in the shape of a hexagon, building most of the pseudo
CC T=25 capsid. Assembled into trimeric units with the help of the
CC chaperone shutoff protein. Transported by pre-protein VI to the nucleus
CC where it associates with other structural proteins to form an empty
CC capsid. Might be involved, through its interaction with host dyneins,
CC in the intracellular microtubule-dependent transport of incoming viral
CC capsid to the nucleus. {ECO:0000256|ARBA:ARBA00024662}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|RuleBase:RU361265}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. Virion
CC {ECO:0000256|RuleBase:RU361265}. Host nucleus
CC {ECO:0000256|RuleBase:RU361265}.
CC -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC {ECO:0000256|RuleBase:RU361265}.
CC -!- SIMILARITY: Belongs to the adenoviridae hexon protein family.
CC {ECO:0000256|ARBA:ARBA00008659, ECO:0000256|RuleBase:RU361265}.
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DR EMBL; KP144329; ALB78146.1; -; Genomic_DNA.
DR OrthoDB; 198at10239; -.
DR Proteomes; UP000150550; Segment.
DR GO; GO:0039623; C:T=25 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR GO; GO:0075521; P:microtubule-dependent intracellular transport of viral material towards nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR Gene3D; 2.70.9.10; Adenovirus Type 2 Hexon, domain 4; 2.
DR Gene3D; 3.90.39.10; Hexon Major Viral Coat Protein, domain 2; 1.
DR Gene3D; 3.90.249.10; Hexon Major Viral Coat Protein, domain 3; 2.
DR InterPro; IPR016108; Adenovirus_Pll_hexon_C.
DR InterPro; IPR016107; Adenovirus_Pll_hexon_N.
DR InterPro; IPR044942; Adenovirus_Pll_hexon_sub2.
DR InterPro; IPR016110; Adenovirus_Pll_hexon_sub3.
DR InterPro; IPR016112; VP_dsDNA_II.
DR Pfam; PF01065; Adeno_hexon; 1.
DR Pfam; PF03678; Adeno_hexon_C; 1.
DR SUPFAM; SSF49749; Group II dsDNA viruses VP; 2.
PE 2: Evidence at transcript level;
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561,
KW ECO:0000256|RuleBase:RU361265};
KW Cytoplasmic inwards viral transport {ECO:0000256|ARBA:ARBA00023120};
KW Host nucleus {ECO:0000256|RuleBase:RU361265};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Late protein {ECO:0000256|RuleBase:RU361265};
KW Microtubular inwards viral transport {ECO:0000256|ARBA:ARBA00022952};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW T=25 icosahedral capsid protein {ECO:0000256|ARBA:ARBA00023275,
KW ECO:0000256|RuleBase:RU361265};
KW Virion {ECO:0000256|ARBA:ARBA00022844, ECO:0000256|RuleBase:RU361265};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 7..592
FT /note="Adenovirus Pll hexon N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01065"
FT DOMAIN 593..824
FT /note="Adenovirus Pll hexon C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03678"
FT REGION 166..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 920 AA; 103226 MW; 16BE505A11771951 CRC64;
MDISNGTPKL DIFHIAGQDA SEYLSENLVN FISSTESYFP INKKFRETVV APTKNVTTEQ
SQRLQVRIVP TLTQDLENSF TARFTIAVGD GRVLDMGSTY FDIRGFLDRG HSFKPYGGTA
YNSMAPRSAQ FNNIRKLTQT TTLSAQLSNI YTVSTSGNAC QAAKTKSDSF TNDKPSPHTG
LLDSTFSPAT EGGIGRAVIM DDDAKETTCY GAYAKATNSN GQQIAAGQSV QKKFTNAGLR
TGSGTSCTGA IAAEKFAVTY PDTRIVAYDD SDKLATRMGS RTNFIGFRDN FIGLMYYDNG
AHSGSLATET GDINLVEQLQ DRNTEISYQY MLADLMSRQH YFSQWNQAVD DYDLNVRVLT
NSGYEEGPPG YVFPSVGMGN YPSEPLFIGQ MVENSGGSTS TQTQNTSAVV GFGSVPTMEM
NVNAYLQRCW LYANVAEYLP DEYKTKVTGT TETDPHTYAY MNAMLPNINV VDLFTNIGGR
YSLDCMDNVN PFNHHRNRGL QYRSQLLGNG RYCNFHIQVP QKFFAVRNLL LTPGTYSYEW
WFRKDPNVVL QSTMGNDLRK DGASIHYTSI NLFASFFPMD HATCSELILM LRNDQNDQSF
MDYMGAKNNL YIVPPNQTNL QIEIPSRSWT AFRGWSFNRV KAAETPAVWS TYDVNFRYSG
SIPYLDGTFY LSHTFNSMSI TFDSAISWPG NDRMLIPNYF EIKRRVDSEG YTTSQSNITK
DFYLIQMSAN YNQGYHGYSF PADKTYRQYD FISNFDPMSI QVPQYGSEAY DLLSESFKQN
VSNNVIINNS GFVPSRDTAI VAAQEGHPYP ANWPMPLIGE HAVEATRTIR KFLCDKYLWT
IPFSSNFLNM GELTDLGQSL LYTESAHSLQ ITFDLDPMPE TTYVYMLYNV FDAVRVNQPN
KNYLSAAYFR TPFATGTASA
//
