ID A0A161JV97_STRLU Unreviewed; 851 AA.
AC A0A161JV97;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=SLA_0080 {ECO:0000313|EMBL:BAU81035.1};
OS Streptomyces laurentii.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=39478 {ECO:0000313|EMBL:BAU81035.1, ECO:0000313|Proteomes:UP000217676};
RN [1] {ECO:0000313|EMBL:BAU81035.1, ECO:0000313|Proteomes:UP000217676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31255 {ECO:0000313|EMBL:BAU81035.1,
RC ECO:0000313|Proteomes:UP000217676};
RA Doi K., Fujino Y., Nagayoshi Y., Ohshima T., Ogata S.;
RT "Complete Genome Sequence of Thiostrepton-Producing Streptomyces laurentii
RT ATCC 31255.";
RL Genome Announc. 4:e00360-16(2016).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
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DR EMBL; AP017424; BAU81035.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A161JV97; -.
DR KEGG; slau:SLA_0080; -.
DR Proteomes; UP000217676; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR009056; Cyt_c-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
DR PROSITE; PS51007; CYTC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:BAU81035.1};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Heme {ECO:0000256|PROSITE-ProRule:PRU00433};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PROSITE-ProRule:PRU00433};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00433}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000217676};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 19..487
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 149..303
FT /note="Cytochrome c"
FT /evidence="ECO:0000259|PROSITE:PS51007"
FT DOMAIN 506..829
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 851 AA; 90678 MW; 1E5277FAC62C730A CRC64;
MTPPVPDTRM PAPHAAGAGK TRDTIDVVGA RTNNLRDVSV SIPKGRLVAF TGVSGSGKTS
LAIDTLHSEA QLRYLEGLSP FVRQYITQRN RPKVDRILGL GATLAVDQRR LNRNPRSTVA
TITGIDGHLG LLYSRLPRIG PDTSTGPAAD TGAGPLTTAH FDRHTPEGSC PDCHGAGGRW
QAQEELVITR PDLPLFEGAS PWYAKWRSGE HVFVPALAAK RGVDLGGPWQ SLPAAFRHDV
LYGTGDEAVE ATVDIPNKNE TARMTYTSSQ PLRGALAEVE RVFVNAQTAD AKQRYLPYMR
KQPCDTCHGS GFDRVARSVR LGGLTYPDLL DVDVREVRRW AGHVADSLDT RQRTVGEPLL
QDLGRRLRLL DRLGLAHLQL SRSAATLSGG ELQRTRLVAQ LGTELSDIIF VLDEPSAGLH
PADKKHLLDI ALELREAGNT VLLVEHDPEL IARADWIVDM GPGAGRLGGE VLVSGSPALA
AANPASVTGR YLAGNGPRLR RTPRPVRDDA DWVELHGLHA HNAAAELLRL PAGRLTCLTG
VSGSGKSSVL GALAAGAAAA LRGTAADTVR EVTGLDGFGW VAVVDQEPLG RTPRSNPATY
SKAFDIVRKL FAATDTARAR GVDASWFSFN TTGGRCDTCT GYGRRLVDMH FLPDMWVVCD
TCDGRRYGPE ALKVTYRGLS IDQVLDLTVA EAGEVFTEPR QLTETLAALD RVGLGYLRLG
QSATELSGGE AQRLKLASAI QRGAASRKAG LVVLDEPVSG LHPSDIQRVV EALDMLLDSG
NTVVVAEHDI PVAASADWVI DLGPGAGPNG GAVVAQGTPD TVAGADTPTA GYLRRYAAGL
PLLDASEDAR R
//
